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1.SUBSTITUTED TETRAHYDRO-1H-PYRAZOLO [3,4-C]PYRIDINES COMPOSITIONS COMPRISING THEM, AND USE 失效
标题翻译: 取代的四氢-1H-吡唑并[3,4-C]吡啶类化合物及其用途公开(公告)号:US20060199837A1
公开(公告)日:2006-09-07
申请号:US11419794
申请日:2006-05-23
申请人: Fabienne Thompson , Patrick Mailliet , Teresa Damiano , Marie-Pierre Cherrier , Francois Clerc , Frank Halley , Herve Bouchard , Laurence Gauzy-Lazo , Bernard Baudoin , Catherine Squaille , Fabrice Viviani , Michel Tabart
发明人: Fabienne Thompson , Patrick Mailliet , Teresa Damiano , Marie-Pierre Cherrier , Francois Clerc , Frank Halley , Herve Bouchard , Laurence Gauzy-Lazo , Bernard Baudoin , Catherine Squaille , Fabrice Viviani , Michel Tabart
IPC分类号: C07D471/02 , A61K31/4745
CPC分类号: C07D471/04
摘要: Substituted tetrahydro-1H-pyrazolo[3,4-c]pyridines, compositions comprising them and use. The present invention relates in particular to novel substituted tetrahydro-1H-pyrazolo[3,4-c]pyridines having therapeutic activity, which can be used in particular in oncology.
摘要翻译: 取代的四氢-1H-吡唑并[3,4-c]吡啶,包含它们的组合物和用途。 本发明特别涉及具有治疗活性的新型取代的四氢-1H-吡唑并[3,4-c]吡啶,其特别可用于肿瘤学。
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2.Substituted tetrahydro-1H-pyrazolo [3,4-c]pyridines compositions comprising them, and use 失效
标题翻译: 包含它们的取代的四氢-1H-吡唑并[3,4-c]吡啶组合物,并使用公开(公告)号:US07435820B2
公开(公告)日:2008-10-14
申请号:US11419794
申请日:2006-05-23
申请人: Fabienne Thompson , Catherine Souaille , Fabrice Viviani , Michel Tabart , Patrick Mailliet , Teresa Damiano , Marie-Pierre Cherrier , Francois Clerc , Frank Halley , Herve Bouchard , Laurence Gauzy-Lazo , Bernard Baudoin
发明人: Fabienne Thompson , Catherine Souaille , Fabrice Viviani , Michel Tabart , Patrick Mailliet , Teresa Damiano , Marie-Pierre Cherrier , Francois Clerc , Frank Halley , Herve Bouchard , Laurence Gauzy-Lazo , Bernard Baudoin
IPC分类号: C07D471/02 , C07D491/02 , C07D498/02 , C07D513/02 , C07D515/02
CPC分类号: C07D471/04
摘要: Substituted tetrahydro-1H-pyrazolo[3,4-c]pyridines, compositions comprising them and use. The present invention relates in particular to novel substituted tetrahydro-1H-pyrazolo[3,4-c]pyridines having therapeutic activity, which can be used in particular in oncology.
摘要翻译: 取代的四氢-1H-吡唑并[3,4-c]吡啶,包含它们的组合物和用途。 本发明特别涉及具有治疗活性的新型取代的四氢-1H-吡唑并[3,4-c]吡啶,其特别可用于肿瘤学。
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3.Substituted tetrahydro-1H-pyrazolo [3,4-c] pyridines, compositions comprising them, and use 失效
标题翻译: 取代的四氢-1H-吡唑并[3,4-c]吡啶,包含它们的组合物,并使用公开(公告)号:US20050096345A1
公开(公告)日:2005-05-05
申请号:US10888611
申请日:2004-07-09
申请人: Fabienne Thompson , Patrick Mailliet , Teresa Damiano , Marie-Pierre Cherrier , Francois Clerc , Frank Halley , Herve Bouchard , Laurence Gauzy-Lazo , Bernard Baudoin , Catherine Souaille , Fabrice Viviani , Michel Tabart
发明人: Fabienne Thompson , Patrick Mailliet , Teresa Damiano , Marie-Pierre Cherrier , Francois Clerc , Frank Halley , Herve Bouchard , Laurence Gauzy-Lazo , Bernard Baudoin , Catherine Souaille , Fabrice Viviani , Michel Tabart
IPC分类号: A61P35/00 , C07D471/04 , C07D471/02 , A61K31/4745
CPC分类号: C07D471/04
摘要: Substituted tetrahydro-1H-pyrazolo[3,4-c]pyridines, compositions comprising them and use. The present invention relates in particular to novel substituted tetrahydro-1H-pyrazolo[3,4-c]pyridines having therapeutic activity, which can be used in particular in oncology.
摘要翻译: 取代的四氢-1H-吡唑并[3,4-c]吡啶,包含它们的组合物和用途。 本发明特别涉及具有治疗活性的新型取代的四氢-1H-吡唑并[3,4-c]吡啶,其特别可用于肿瘤学。
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4.Substituted tetrahydro-1H-pyrazolo [3,4-c] pyridines, compositions comprising them, and use 失效
标题翻译: 取代的四氢-1H-吡唑并[3,4-c]吡啶,包含它们的组合物,并使用公开(公告)号:US07109340B2
公开(公告)日:2006-09-19
申请号:US10888611
申请日:2004-07-09
申请人: Fabienne Thompson , Patrick Mailliet , Teresa Damiano , Marie-Pierre Cherrier , Francois Clerc , Frank Halley , Hervé Bouchard , Laurence Gauzy-Lazo , Bernard Baudoin , Catherine Souaille , Fabrice Viviani , Michel Tabart
发明人: Fabienne Thompson , Patrick Mailliet , Teresa Damiano , Marie-Pierre Cherrier , Francois Clerc , Frank Halley , Hervé Bouchard , Laurence Gauzy-Lazo , Bernard Baudoin , Catherine Souaille , Fabrice Viviani , Michel Tabart
IPC分类号: C07D471/02 , C07D491/02 , C07D498/02 , C07D513/02 , C07D515/02
CPC分类号: C07D471/04
摘要: Substituted tetrahydro-1H-pyrazolo[3,4-c]pyridines, compositions comprising them and use. The present invention relates in particular to novel substituted tetrahydro-1H-pyrazolo[3,4-c]pyridines having therapeutic activity, which can be used in particular in oncology.
摘要翻译: 取代的四氢-1H-吡唑并[3,4-c]吡啶,包含它们的组合物和用途。 本发明特别涉及具有治疗活性的新型取代的四氢-1H-吡唑并[3,4-c]吡啶,其特别可用于肿瘤学。
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5.Novel organophosphorus derivatives of indazoles and use thereof as medicinal products 失效
标题翻译: 吲唑的新型有机磷衍生物及其作为药用产品公开(公告)号:US20050137171A1
公开(公告)日:2005-06-23
申请号:US11016595
申请日:2004-12-17
申请人: Marie-Pierre Cherrier , Francois Clerc , Alain Commercon , Patrick Mailliet , Herve Minoux , Bruno Filoche-Romme
发明人: Marie-Pierre Cherrier , Francois Clerc , Alain Commercon , Patrick Mailliet , Herve Minoux , Bruno Filoche-Romme
IPC分类号: C07F9/38 , C07F9/44 , C07F9/6503 , C07F9/6558 , A61K31/675
CPC分类号: C07F9/65586 , C07F9/65038 , C07F9/65583
摘要: The present invention relates in particular to novel chemical compounds, particularly to novel organophosphorus derivatives of indazoles, to the compositions containing them, and to the use thereof as medicinal products for treating cancers.
摘要翻译: 本发明特别涉及新化合物,特别是涉及吲唑类的新型有机磷衍生物,含有它们的组合物,以及作为治疗癌症的药物的用途。
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6.Organophosphorus derivatives of indazoles and use thereof as medicinal products 失效
标题翻译: 吲唑的有机磷衍生物及其作为药用产品公开(公告)号:US07491710B2
公开(公告)日:2009-02-17
申请号:US11016595
申请日:2004-12-17
申请人: Marie-Pierre Cherrier , Francois Clerc , Alain Commercon , Patrick Mailliet , Hervé Minoux , Bruno Filoche-Rommé
发明人: Marie-Pierre Cherrier , Francois Clerc , Alain Commercon , Patrick Mailliet , Hervé Minoux , Bruno Filoche-Rommé
IPC分类号: A61K31/675
CPC分类号: C07F9/65586 , C07F9/65038 , C07F9/65583
摘要: The present invention relates in particular to novel chemical compounds, particularly to novel organophosphorus derivatives of indazoles, to the compositions containing them, and to the use thereof as medicinal products for treating cancers.
摘要翻译: 本发明特别涉及新化合物,特别是涉及吲唑类的新型有机磷衍生物,含有它们的组合物,以及作为治疗癌症的药物的用途。
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7.1,3-Diarylprop-2-en-1-ones, compositions containing them and use thereof 审中-公开
标题翻译: 1,3-二芳基丙-2-烯-1-酮,含有它们的组合物及其用途公开(公告)号:US20050203170A1
公开(公告)日:2005-09-15
申请号:US11108855
申请日:2005-04-19
申请人: Patrick Mailliet , Cecile Combeau , Marie-Christine Bissery , Marie-Pierre Cherrier , Thomas Caulfield , Gilles Tiraboschi
发明人: Patrick Mailliet , Cecile Combeau , Marie-Christine Bissery , Marie-Pierre Cherrier , Thomas Caulfield , Gilles Tiraboschi
IPC分类号: C07C225/22 , C07C237/04 , C07C279/36 , C07D207/16 , C07D209/08 , C07D405/06 , A61K31/401 , A61K31/135 , A61K31/198
CPC分类号: C07D405/06 , C07C225/22 , C07C237/04 , C07C279/36 , C07D207/16 , C07D209/08
摘要: 1,3-Diarylprop-2-en-1-ones and derivatives, compositions containing them, manufacturing process and use. Substituted 1,3-diarylprop-2-en-1-ones with therapeutic activity may be used in oncology.
摘要翻译: 1,3-二芳基丙-2-烯-1-酮及其衍生物,含有它们的组合物,制造方法和用途。 具有治疗活性的取代的1,3-二芳基丙-2-烯-1-酮可用于肿瘤学。
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8.Methods for preparing N-[(aliphatic or aromatic)carbonyl)]-2-aminoaetamide compounds and for cyclizing such compounds 有权
标题翻译: 制备N - [(脂族或芳族)羰基)] - 2-氨基乙酰胺化合物和使这些化合物环化的方法公开(公告)号:US06492553B1
公开(公告)日:2002-12-10
申请号:US09368213
申请日:1999-08-04
申请人: Christopher Hulme , George C. Morton , Joseph M. Salvino , Richard F. Labaudiniere , Helen J. Mason , Matthew M. Morrissette , Liang Ma , Marie-Pierre Cherrier
发明人: Christopher Hulme , George C. Morton , Joseph M. Salvino , Richard F. Labaudiniere , Helen J. Mason , Matthew M. Morrissette , Liang Ma , Marie-Pierre Cherrier
IPC分类号: C07C23102
CPC分类号: C07D207/273 , A61K38/00 , C07C231/14 , C07C269/06 , C07C2601/02 , C07C2601/16 , C07D231/12 , C07D233/28 , C07D233/32 , C07D233/56 , C07D233/64 , C07D233/70 , C07D233/74 , C07D233/90 , C07D235/26 , C07D239/10 , C07D241/08 , C07D241/18 , C07D241/44 , C07D243/14 , C07D243/24 , C07D249/08 , C07D295/13 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D471/04 , C07D487/04 , C07D487/14 , C07F9/645 , C07K5/06139 , C40B40/00 , C07C237/22 , C07C271/28
摘要: A method for preparing a N-[(aliphatic or aromatic)carbonyl)]-2-aminoacetamide compound, and for preparing a cyclized compound therefrom, as well as novel resin bound intermediate compounds that are useful for preparing such compounds.
摘要翻译: 制备N - [(脂族或芳族)羰基)] - 2-氨基乙酰胺化合物,以及由其制备环化合物的方法,以及可用于制备这些化合物的新型树脂结合中间体化合物。
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9.Substituted indazoles, compositions containing them, method of production and use 有权
标题翻译: 取代的吲唑,含有它们的组合物,生产和使用方法公开(公告)号:US07473701B2
公开(公告)日:2009-01-06
申请号:US10963880
申请日:2004-10-13
申请人: Dominique Damour , Jean-Christophe Carry , Patrick Nemecek , Corinne Terrier , Frederico Nardi , Bruno Filoche-Romme , Marie-Pierre Cherrier , Daniel Bezard
发明人: Dominique Damour , Jean-Christophe Carry , Patrick Nemecek , Corinne Terrier , Frederico Nardi , Bruno Filoche-Romme , Marie-Pierre Cherrier , Daniel Bezard
IPC分类号: A61K31/415 , C07D231/54
CPC分类号: C07D231/56
摘要: Substituted indazoles, compositions containing them, method of production and use. The present invention relates in particular to novel specific substituted indazoles exhibiting kinase-inhibiting activity, having therapeutic activity, in particular in oncology.
摘要翻译: 取代的吲唑,含有它们的组合物,生产和使用方法。 本发明特别涉及具有激酶抑制活性的新型特异性取代的吲唑,具有治疗活性,特别是肿瘤学。
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10.Pyrazolylbenzimidazole derivatives, compositions containing them and use thereof 有权
标题翻译: 吡唑基苯并咪唑衍生物,含有它们的组合物及其用途公开(公告)号:US09126969B2
公开(公告)日:2015-09-08
申请号:US12338176
申请日:2008-12-18
申请人: Marie-Pierre Cherrier , Eric Parmantier , Hervé Minoux , François Clerc , Odile Angouillant-Boniface , Maurice Brollo , Laurent Schio
发明人: Marie-Pierre Cherrier , Eric Parmantier , Hervé Minoux , François Clerc , Odile Angouillant-Boniface , Maurice Brollo , Laurent Schio
IPC分类号: C07D413/14 , C07D401/14 , C07D235/04 , C07D403/04 , C07D403/14 , C07D405/14
CPC分类号: C07D403/04 , C07D235/04 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14
摘要: The disclosure relates to compounds of formula (I): wherein R1, R2, R3, R4, and R5 are as defined in the disclosure, to the compositions containing them and to the use thereof as medicaments, in particular as anticancer agents. The disclosure also relates to the process for preparing the compounds of formula (I) and to reaction intermediates.
摘要翻译: 本公开涉及式(I)的化合物:其中R 1,R 2,R 3,R 4和R 5如本公开所定义,含有它们的组合物及其作为药物,特别是作为抗癌剂的用途。 本公开还涉及制备式(I)化合物和反应中间体的方法。
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