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1.发明授权Process for the preparation of ibodutant (MEN15596) and related intermediates 有权制备ibodutant（MEN15596）及相关中间体的方法公开(公告)号：US08431684B2
公开(公告)日：2013-04-30
申请号：US13321501
申请日：2010-05-11
IPC分类号： A61K38/06
CPC分类号： C07D409/12
摘要： This invention relates to a novel process for synthesizing the product ibodutant shown in the figure below, consisting of a small number of high-yield steps involving reagents and solvents with low environmental impact, characterized by the coupling of two portions, compounds (3) and (4), one of which (3) is synthesized by coupling of 6-methyl-2-benzo[b]thiophenecarboxylic acid (1) with 1-amino-alpha-alpha-cyclopentan carboxylic acid and subsequent cyclization with oxazolone, while the other, compound (4), is obtained from suitable highly selective functionalizations of 4-aminomethylpiperidine (2).
摘要翻译： 本发明涉及一种合成下图所示产品的新颖方法，该方法由少量高产率步骤组成，包括试剂和低环境影响的溶剂，其特征在于两部分的化合物（3）和 （4），其中一个（3）通过6-甲基-2-苯并[b]噻吩甲酸（1）与1-氨基-α-α-环戊烷羧酸的偶合合成，随后与恶唑酮环化，而 其他化合物（4）由4-氨基甲基哌啶（2）的合适的高度选择性官能化得到。
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2.发明申请PROCESS FOR THE PREPARATION OF IBODUTANT (MEN15596) AND RELATED INTERMEDIATES 有权制备IBODUTANT（MEN15596）及相关中间体的方法公开(公告)号：US20120065370A1
公开(公告)日：2012-03-15
申请号：US13321501
申请日：2010-05-11
IPC分类号： C07K5/097
CPC分类号： C07D409/12
摘要： This invention relates to a novel process for synthesising the product ibodutant shown in the figure below, consisting of a small number of high-yield steps involving reagents and solvents with low environmental impact, characterised by the coupling of two portions, compounds (3) and (4), one of which (3) is synthesised by coupling of 6-methyl-2-benzo[b]thiophenecarboxylic acid (1) with 1-amino-alpha-alpha-cyclopentan carboxylic acid and subsequent cyclization with oxazolone, while the other, compound (4), is obtained from suitable highly selective functionalisations of 4-aminomethylpiperidine (2)
摘要翻译： 本发明涉及一种合成下图所示产品的新型方法，该方法由少量高产率步骤组成，包括试剂和低环境影响的溶剂，其特征在于两部分化合物（3）和 （4），其中一个（3）通过6-甲基-2-苯并[b]噻吩甲酸（1）与1-氨基-α-α-环戊烷羧酸的偶合合成，随后与恶唑酮环化，而 其他化合物（4）由4-氨基甲基哌啶（2）的合适的高选择性官能团获得，
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3.发明授权Acrylamide copolymers containing (meth)acrylamide benzene dicarboxylic units 失效含有（甲基）丙烯酰胺苯甲酸二甲基酰胺单体的丙烯酰胺共聚物
公开(公告)号：US5103057A
公开(公告)日：1992-04-07
申请号：US629408
申请日：1990-12-18
IPC分类号： C07C233/55 , C08F20/52 , C08F220/58 , C08F220/60
CPC分类号： C07C233/55 , C08F220/58
摘要： New acrylamide copolymers formed by (meth)acrylamide benzene dicarboxylic monomer units in accordance with the following formula: ##STR1## wherein R is H or CH.sub.3 ; X is H or an alkaline metal or NH.sub.4 ; and wherein the COOX groups may be in ortho-, meta- or para- position in relation to each other, preferably being in ortho- position to each other; and of (meth)acrylamide monomer (II) units.
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4.发明授权
公开(公告)号：US5089577A
公开(公告)日：1992-02-18
申请号：US629409
申请日：1990-12-18
IPC分类号： C07C233/49 , C08F20/10 , C08F20/52 , C08F20/58 , C08F20/60
CPC分类号： C08F20/58 , C07C233/49
摘要： New homopolymers formed by malonic (meth)acrylamide monomer units according to the following formula: ##STR1## wherein R is H or CH.sub.3 ; X is H or an alkaline metal or NH.sub.4.sup.+ ; and copolymers formed by (meth)acrylamide monomer units (I) and monomer units (II).
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5.发明授权Gellable aqueous compositions containing polymers with special chelating functional groups useful for recovering oil from an oil field 失效含有可用于从油田回收油的具有特殊螯合官能团的聚合物的可胶凝含水组合物
公开(公告)号：US5256315A
公开(公告)日：1993-10-26
申请号：US793524
申请日：1991-11-18
IPC分类号： B01J13/00 , C08F220/58 , C08K3/00 , C08L25/00 , C08L25/18 , C08L33/04 , C08L33/24 , C09K8/12 , C09K8/512 , C09K8/68 , C09K8/88 , E21B43/26 , E21B43/16
CPC分类号： C09K8/887 , C08F220/58 , C08K3/0016 , C09K8/12 , C09K8/512 , C09K8/685 , Y10S507/902 , Y10S507/903 , Y10S507/922 , Y10S507/935
摘要： Gellable compositions containing:(a) water;(b) a water-soluble organic polymer bearing special chelating functional groups;(c) a multi-valent metal ion capable of causing the polymer to crosslink,are useful to recover oil from a oil field.Said compositions make it possible gels to be obtained which are endowed with improved physical properties and show a higher stability under the conditions prevailing in the oil field.
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公开(公告)号：US5042990A
公开(公告)日：1991-08-27
申请号：US441265
申请日：1989-11-27
申请人： Fabrizio Bonaccorsi , Aldo Prevedello , Armando Marcotullio , Edoardo Platone , Arnaldo Roggero , Elio Donati
发明人： Fabrizio Bonaccorsi , Aldo Prevedello , Armando Marcotullio , Edoardo Platone , Arnaldo Roggero , Elio Donati
摘要： Storage-stable, pumpable, concentrated dispersions of coal in water contain a non-ionic additive constituted by a polymer containing polyethoxy chains grafted onto suitably functionalized polystyrenes having a molecular weight comprised within the range of from 500 to 15000.
摘要翻译： 储存稳定的可泵送的煤在水中的浓缩分散体含有非离子添加剂，该非离子添加剂由含有分子量在500至15000范围内的适当官能化的聚苯乙烯上的聚乙氧基链的聚合物构成。
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