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公开(公告)号：US07696324B2
公开(公告)日：2010-04-13
申请号：US11519322
申请日：2006-09-11
申请人： Fang Fang , Lori Kohlstaedt , John Reno
发明人： Fang Fang , Lori Kohlstaedt , John Reno
CPC分类号： C07K16/2896 , A61K2039/505 , C07K16/2821 , C07K2317/24 , C07K2317/622 , C07K2317/92 , C07K2319/00 , Y02A50/412
摘要： Humanized antibodies that bind ICAM-1 are provided. Antibodies include those selected from: SEQ ID NO:1 and 3 (HumA); SEQ ID NO:5 and 7 (HumB); SEQ ID NO:9 and 11 (HumC); SEQ ID NO:13 and 15 (HumD); SEQ ID NO:17 and 19 (HumE); SEQ ID NO:21 and 23 (HumF); SEQ ID NO:25 and 27 (HumG); SEQ ID NO:29 and 31 (HumH); and SEQ ID NO:33 and 35 (HumI). Subsequences of the humanized antibodies capable of binding an ICAM-1 epitope are also provided. Methods of inhibiting pathogen infection (e.g., HRV) of a cell employing humanized antibodies capable of binding an ICAM-1 epitope are further provided.
摘要翻译： 提供了结合ICAM-1的人源化抗体。 抗体包括选自：SEQ ID NO：1和3（HumA）的那些; SEQ ID NO：5和7（HumB）; SEQ ID NO：9和11（HumC）; SEQ ID NO：13和15（HumD）; SEQ ID NO：17和19（HumE）; SEQ ID NO：21和23（HumF）; SEQ ID NO：25和27（HumG）; SEQ ID NO：29和31（HumH）; 和SEQ ID NO：33和35（HumI）。 还提供了能够结合ICAM-1表位的人源化抗体的子序列。 还提供了使用能够结合ICAM-1表位的人源化抗体抑制细胞病原体感染（例如HRV）的方法。
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公开(公告)号：US20070071742A1
公开(公告)日：2007-03-29
申请号：US11519322
申请日：2006-09-11
申请人： Fang Fang , Lori Kohlstaedt , John Reno
发明人： Fang Fang , Lori Kohlstaedt , John Reno
IPC分类号： A61K39/395 , C12N5/06 , C12N5/16
CPC分类号： C07K16/2896 , A61K2039/505 , C07K16/2821 , C07K2317/24 , C07K2317/622 , C07K2317/92 , C07K2319/00 , Y02A50/412
摘要： Humanized antibodies that bind ICAM-1 are provided. Antibodies include those selected from: SEQ ID NO:1 and 3 (HumA); SEQ ID NO:5 and 7 (HumB); SEQ ID NO:9 and 11 (HumC); SEQ ID NO:13 and 15 (HumD); SEQ ID NO:17 and 19 (HumE); SEQ ID NO:21 and 23 (HumF); SEQ ID NO:25 and 27 (HumG); SEQ ID NO:29 and 31 (HumH); and SEQ ID NO:33 and 35 (HumI). Subsequences of the humanized antibodies capable of binding an ICAM-1 epitope are also provided. Methods of inhibiting pathogen infection (e.g., HRV) of a cell employing humanized antibodies capable of binding an ICAM-1 epitope are further provided.
摘要翻译： 提供了结合ICAM-1的人源化抗体。 抗体包括选自：SEQ ID NO：1和3（HumA）的那些; SEQ ID NO：5和7（HumB）; SEQ ID NO：9和11（HumC）; SEQ ID NO：13和15（HumD）; SEQ ID NO：17和19（HumE）; SEQ ID NO：21和23（HumF）; SEQ ID NO：25和27（HumG）; SEQ ID NO：29和31（HumH）; 和SEQ ID NO：33和35（HumI）。 还提供了能够结合ICAM-1表位的人源化抗体的子序列。 还提供了使用能够结合ICAM-1表位的人源化抗体抑制细胞病原体感染（例如HRV）的方法。
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公开(公告)号：US08586712B2
公开(公告)日：2013-11-19
申请号：US12748304
申请日：2010-03-26
申请人： Fang Fang , Lori Kohlstaedt , John Reno
发明人： Fang Fang , Lori Kohlstaedt , John Reno
IPC分类号： C07K16/28 , C12N15/13 , C12N15/63 , A61K39/395
CPC分类号： C07K16/2896 , A61K2039/505 , C07K16/2821 , C07K2317/24 , C07K2317/622 , C07K2317/92 , C07K2319/00 , Y02A50/412
摘要： Humanized antibodies that bind ICAM-1 are provided. Antibodies include those selected from: SEQ ID NO:1 and 3 (HumA); SEQ ID NO:5 and 7 (HumB); SEQ ID NO:9 and 11 (HumC); SEQ ID NO:13 and 15 (HumD); SEQ ID NO:17 and 19 (HumE); SEQ ID NO:21 and 23 (HumF); SEQ ID NO:25 and 27 (HumG); SEQ ID NO:29 and 31 (HumH); and SEQ ID NO:33 and 35 (HumI). Subsequences of the humanized antibodies capable of binding an ICAM-1 epitope are also provided. Methods of inhibiting pathogen infection (e.g., HRV) of a cell employing humanized antibodies capable of binding an ICAM-1 epitope are further provided.
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公开(公告)号：US20060029545A1
公开(公告)日：2006-02-09
申请号：US11236272
申请日：2005-09-27
申请人： Sudhakar Kasina , Alan Fritzberg , Jonathan Tait , John Reno
发明人： Sudhakar Kasina , Alan Fritzberg , Jonathan Tait , John Reno
CPC分类号： C07K7/06 , A61K47/54 , A61K47/547 , A61K47/549 , A61K51/087 , A61K51/088 , A61K2123/00 , C07K1/13 , C07K14/4721
摘要： Radiolabeled annexin and modified annexin conjugates useful for imaging vascular thrombi are described. Methods for making and using such radiolabeled annexin conjugates are also provided.
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5.发明申请公开(公告)号：US20050100545A1
公开(公告)日：2005-05-12
申请号：US10631660
申请日：2003-07-31
申请人： Scott Graves , John Reno , Robert Mallett , Mark Hylarides
发明人： Scott Graves , John Reno , Robert Mallett , Mark Hylarides
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , A61K47/48 , A61P35/00 , C07K1/113 , C07K16/00 , C07K16/30 , C07K16/46 , C12N1/15 , C12N1/19 , C12N5/10 , C12N15/09 , C12P21/08 , C07K16/44
CPC分类号： B82Y5/00 , A61K38/00 , A61K47/68 , A61K47/6898 , A61K2039/505 , C07K1/1133 , C07K16/00 , C07K16/30 , C07K2317/24 , C07K2317/41 , C07K2317/732 , C07K2317/734 , C07K2319/00
摘要： Humanized antibodies which bind the NR-LU-13 antigen, conjugates containing such antibodies, and their use in pretargeting methods and conventional antibody therapy and immunodiagnosis are provided.
摘要翻译： 提供了结合NR-LU-13抗原的人源化抗体，含有这些抗体的缀合物，以及它们在预靶向方法和常规抗体治疗和免疫诊断中的用途。
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公开(公告)号：US20050036948A1
公开(公告)日：2005-02-17
申请号：US10820653
申请日：2004-04-08
申请人： Sudhakar Kasina , John Reno , Louis Theodore
发明人： Sudhakar Kasina , John Reno , Louis Theodore
IPC分类号： A61K47/48 , A61K51/08 , C07K1/13 , C07K7/06 , C07K14/47 , G01N33/53 , A61K49/00 , G01N33/567
CPC分类号： C07K7/06 , A61K47/54 , A61K47/547 , A61K47/549 , A61K51/087 , A61K51/088 , A61K2123/00 , C07K1/13 , C07K14/4721
摘要： Radiolabeled annexin and modified annexin conjugates useful for imaging vascular thrombi are described. Methods for making and using such radiolabeled annexin conjugates are also provided.
摘要翻译： 描述了可用于成像血管血栓的放射性标记的膜联蛋白和修饰的膜联蛋白缀合物。 还提供了制备和使用这种放射性标记的膜联蛋白缀合物的方法。
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7.发明申请Humanized antibodies that bind to the antigen bound by antibody NR-LU-13 and their use in pretargeting methods 审中-公开与由抗体NR-LU-13结合的抗原结合的人源化抗体及其在预靶向方法中的用途公开(公告)号：US20050008635A1
公开(公告)日：2005-01-13
申请号：US10787067
申请日：2004-02-25
申请人： Scott Graves , John Reno , Robert Mallett , Mark Hylarides , Stephen Searle , Andrew Henry , Jan Pedersen , Anthony Rees
发明人： Scott Graves , John Reno , Robert Mallett , Mark Hylarides , Stephen Searle , Andrew Henry , Jan Pedersen , Anthony Rees
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , A61K47/48 , A61P35/00 , C07K1/113 , C07K16/00 , C07K16/30 , C07K16/46 , C12N1/15 , C12N1/19 , C12N5/10 , C12N15/09 , C12P21/08 , C07K16/44
CPC分类号： B82Y5/00 , A61K38/00 , A61K47/68 , A61K47/6898 , A61K2039/505 , C07K1/1133 , C07K16/00 , C07K16/30 , C07K2317/24 , C07K2317/41 , C07K2317/732 , C07K2317/734 , C07K2319/00
摘要： Humanized antibodies which bind the NR-LU-13 antigen, conjugates containing such antibodies, and their use in pretargeting methods and conventional antibody therapy and immunodiagnosis are provided.
摘要翻译： 提供了结合NR-LU-13抗原的人源化抗体，含有这些抗体的缀合物，以及它们在预靶向方法和常规抗体治疗和免疫诊断中的用途。
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