公开(公告)号：US08450340B2

公开(公告)日：2013-05-28

申请号：US12968505

申请日：2010-12-15

Applicant: John Hood ,  Sunil Kumar K C ,  David Mark Wallace

Inventor： John Hood ,  Sunil Kumar K C ,  David Mark Wallace

IPC: A01N43/42 ,  C07D471/02 ,  C07D491/02 ,  C07D498/02

CPC classification number: A61K31/5377 ,  A61K31/415 ,  A61K31/437 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  C07D401/14 ,  C07D471/04 ,  C07D471/14 ,  C07D487/04 ,  C07D519/00

Abstract: Provided herein are compounds according to Formula I and pharmaceutically acceptable salts thereof, and compositions comprising the same, for use in various methods, including treating cancers such as colon, ovarian, pancreatic, breast, liver, prostate and hematologic cancers:

公开(公告)号：US07235546B2

公开(公告)日：2007-06-26

申请号：US11592542

申请日：2006-11-03

Applicant: Jagadish Sircar ,  Sunil Kumar K C ,  Wenbin Ying

Inventor： Jagadish Sircar ,  Sunil Kumar K C ,  Wenbin Ying

IPC: A61K31/551 ,  C07D401/04

CPC classification number: A61K31/496 ,  A61K31/52 ,  A61K31/54 ,  A61K31/56 ,  C07D215/54 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

Abstract: Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R3, R4, X, and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.

公开(公告)号：US07173036B2

公开(公告)日：2007-02-06

申请号：US10778884

申请日：2004-02-13

Applicant: Jagadish Sircar ,  Sunil Kumar K C ,  Wenbin Ying

Inventor： Jagadish Sircar ,  Sunil Kumar K C ,  Wenbin Ying

IPC: A61K31/496 ,  C07D401/04 ,  A61K31/551 ,  A61K31/4704 ,  A61K31/4709

CPC classification number: A61K31/496 ,  A61K31/52 ,  A61K31/54 ,  A61K31/56 ,  C07D215/54 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

Abstract: Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R3, R4, X, and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.

公开(公告)号：US07157469B2

公开(公告)日：2007-01-02

申请号：US11416004

申请日：2006-05-02

Applicant: Federico C. A. Gaeta ,  Andrew Baird ,  Jerry Anchin ,  Wenbin Ying ,  Robert Florkiewicz ,  Jagadish Sircar ,  Sunil Kumar K. C.

Inventor： Federico C. A. Gaeta ,  Andrew Baird ,  Jerry Anchin ,  Wenbin Ying ,  Robert Florkiewicz ,  Jagadish Sircar ,  Sunil Kumar K. C.

IPC: A61K31/4709 ,  C07D401/02

CPC classification number: C07D401/12 ,  C07D215/42 ,  C07D215/54 ,  C07D405/12 ,  C07D409/12

Abstract: Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R3, R4, X, Y and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.

公开(公告)号：US07084141B2

公开(公告)日：2006-08-01

申请号：US11268375

申请日：2005-11-07

Applicant: Federico C. A. Gaeta ,  Andrew Baird ,  Jerry Anchin ,  Wenbin Ying ,  Robert Florkiewicz ,  Jagadish Sircar ,  Sunil Kumar K. C.

Inventor： Federico C. A. Gaeta ,  Andrew Baird ,  Jerry Anchin ,  Wenbin Ying ,  Robert Florkiewicz ,  Jagadish Sircar ,  Sunil Kumar K. C.

IPC: A61K31/496

CPC classification number: C07D401/12 ,  C07D215/42 ,  C07D215/54 ,  C07D405/12 ,  C07D409/12

Abstract: Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R3, R4, X, Y and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.

Abstract translation: 提供了MIF的抑制剂，其可用于治疗各种疾病，包括治疗与MIF活性相关的病理状况。 MIF的抑制剂具有以下结构：包括其立体异构体，前药和药学上可接受的盐，其中n，R 1，R 2，R 3， >，R 4，X，Y和Z如本文所定义。 还提供了含有与药学上可接受的载体组合的MIF抑制剂的组合物，以及使用该组合物的方法。

公开(公告)号：US07312220B2

公开(公告)日：2007-12-25

申请号：US11592364

申请日：2006-11-03

Applicant: Jagadish Sircar ,  Sunil Kumar K C ,  Wenbin Ying

Inventor： Jagadish Sircar ,  Sunil Kumar K C ,  Wenbin Ying

IPC: A61K31/496 ,  A61K31/5377

CPC classification number: A61K31/496 ,  A61K31/52 ,  A61K31/54 ,  A61K31/56 ,  C07D215/54 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

Abstract: Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R3, R4, X, and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.

公开(公告)号：US07514225B2

公开(公告)日：2009-04-07

申请号：US11182360

申请日：2005-07-15

Applicant: Federico C. A. Gaeta ,  Andrew Baird ,  Jerry Anchin ,  Wenbin Ying ,  Robert Florkiewicz ,  Jagadish Sircar ,  Sunil Kumar K. C.

Inventor： Federico C. A. Gaeta ,  Andrew Baird ,  Jerry Anchin ,  Wenbin Ying ,  Robert Florkiewicz ,  Jagadish Sircar ,  Sunil Kumar K. C.

IPC: G01N33/53 ,  C12N5/00 ,  C07K16/24 ,  C07K14/52

CPC classification number: C07D401/12 ,  C07D215/42 ,  C07D215/54 ,  C07D405/12 ,  C07D409/12

Abstract: Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R3, R4, X, Y and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.

Abstract translation: 提供了MIF的抑制剂，其可用于治疗各种疾病，包括治疗与MIF活性相关的病理状况。 MIF的抑制剂具有以下结构：包括其立体异构体，前药和药学上可接受的盐，其中n，R 1，R 2，R 3，R 4，X，Y和Z如本文所定义。 还提供了含有与药学上可接受的载体组合的MIF抑制剂的组合物，以及使用该组合物的方法。

公开(公告)号：US07432374B2

公开(公告)日：2008-10-07

申请号：US11687611

申请日：2007-03-16

Applicant: Federico C. A. Gaeta ,  Andrew Baird ,  Jerry Anchin ,  Wenbin Ying ,  Robert Florkiewicz ,  Jagadish Sircar ,  Sunil Kumar K. C.

Inventor： Federico C. A. Gaeta ,  Andrew Baird ,  Jerry Anchin ,  Wenbin Ying ,  Robert Florkiewicz ,  Jagadish Sircar ,  Sunil Kumar K. C.

IPC: C07D215/42 ,  C07D215/54 ,  C07D401/06 ,  C07D403/06

CPC classification number: C07D401/12 ,  C07D215/42 ,  C07D215/54 ,  C07D405/12 ,  C07D409/12

Abstract: Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R3, R4, X, Y and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.

Abstract translation: 提供了MIF的抑制剂，其可用于治疗各种疾病，包括治疗与MIF活性相关的病理状况。 MIF的抑制剂具有以下结构：包括其立体异构体，前药和药学上可接受的盐，其中n，R 1，R 2，R 3， >，R 4，X，Y和Z如本文所定义。 还提供了含有与药学上可接受的载体组合的MIF抑制剂的组合物，以及使用该组合物的方法。

公开(公告)号：US07365200B2

公开(公告)日：2008-04-29

申请号：US11687598

申请日：2007-03-16

Applicant: Jagadish Sircar ,  Sunil Kumar K. C. ,  Timothy James Davis ,  Wenbin Ying

Inventor： Jagadish Sircar ,  Sunil Kumar K. C. ,  Timothy James Davis ,  Wenbin Ying

IPC: C07D495/04 ,  A61K31/496

CPC classification number: C07D495/04 ,  C07D498/02

Abstract: Inhibitors of macrophage migration inhibitory factor having a thienopyridinone backbone are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with macrophage migration inhibitory factor activity. The inhibitors of macrophage migration inhibitory factor have the following structures: including forms such as stereoisomers, free forms, pharmaceutically acceptable salts or esters thereof, solvates, or combinations of such forms, wherein n, R1, R2, R3, X, and Y are as defined herein. Compositions comprising an inhibitor of macrophage migration inhibitory factor in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.

Abstract translation: 提供具有噻吩并吡啶酮骨架的巨噬细胞迁移抑制因子的抑制剂，其可用于治疗各种疾病，包括治疗与巨噬细胞迁移抑制因子活性相关的病理状况。 巨噬细胞迁移抑制因子的抑制剂具有以下结构：包括形式如立体异构体，游离形式，药学上可接受的盐或酯，溶剂合物或这些形式的组合，其中n，R 1，R R 3，R 3，X和Y如本文所定义。 还提供了包含与药学上可接受的载体组合的巨噬细胞迁移抑制因子抑制剂的组合物，以及其用途的方法。

公开(公告)号：US07202248B2

公开(公告)日：2007-04-10

申请号：US11344938

申请日：2006-01-31

Applicant: Federico C. A. Gaeta ,  Andrew Baird ,  Jerry Anchin ,  Wenbin Ying ,  Robert Florkiewicz ,  Jagadish Sircar ,  Sunil Kumar K. C.

Inventor： Federico C. A. Gaeta ,  Andrew Baird ,  Jerry Anchin ,  Wenbin Ying ,  Robert Florkiewicz ,  Jagadish Sircar ,  Sunil Kumar K. C.

IPC: A61K31/496

CPC classification number: C07D401/12 ,  C07D215/42 ,  C07D215/54 ,  C07D405/12 ,  C07D409/12

Abstract: Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R3, R4, X, Y and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.

Abstract translation: 提供了MIF的抑制剂，其可用于治疗各种疾病，包括治疗与MIF活性相关的病理状况。 MIF的抑制剂具有以下结构：