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    Application of recombinant immunoregulatory protein of ganoderma lucidum in preparation of drug for treating focal cerebral ischemia
    3.
    发明申请
    Application of recombinant immunoregulatory protein of ganoderma lucidum in preparation of drug for treating focal cerebral ischemia 审中-公开
    灵芝重组免疫调节蛋白在制备治疗局灶性脑缺血的药物中的应用

    公开(公告)号：US20160199439A1

    公开(公告)日：2016-07-14

    申请号：US14912914

    申请日：2014-06-13

    申请人： Xitian ZHANG ,  Fei SUN

    发明人： Xitian Zhang ,  Fei Sun ,  Chongyang Liang

    IPC分类号： A61K38/16

    CPC分类号： A61K38/168

    摘要： An application of a recombinant immunoregulatory protein of ganoderma lucidum (rLZ-8) expressed by Pichia pastoris in a preparation of a drug for treating focal cerebral ischemia is provided. The rLZ-8 is able to treat a neurological function injury, decrease a neurological severity score caused by a cerebral injury and decrease an ED-1 positive cell number, so as to decrease an inflammatory response and inhibit apoptosis.

    摘要翻译： 提供了由巴斯德毕赤酵母表达的灵芝重组免疫调节蛋白（rLZ-8）在制备治疗局灶性脑缺血的药物中的应用。 rLZ-8能够治疗神经功能损伤，降低脑损伤引起的神经系统严重程度评分，降低ED-1阳性细胞数，减少炎症反应，抑制细胞凋亡。

    Apparatus and Method for Removing Unwanted Optical Radiation from an Optical Fiber
    6.
    发明申请
    Apparatus and Method for Removing Unwanted Optical Radiation from an Optical Fiber 审中-公开

    公开(公告)号：US20100303104A1

    公开(公告)日：2010-12-02

    申请号：US12863099

    申请日：2009-01-19

    申请人： Nicolas Bennetts ,  Kevin Patrick Sheehan ,  Fei Sun

    发明人： Nicolas Bennetts ,  Kevin Patrick Sheehan ,  Fei Sun

    IPC分类号： H01S3/30 ,  G02B6/26

    CPC分类号： G02B6/14 ,  G02B6/4296 ,  H01S3/06704 ,  H01S3/06708

    摘要： Apparatus comprising a source of optical radiation (15), an optical fibre (1), and an absorbing material (2), wherein; the optical fibre (1) comprises a core (37), at least one cladding (38), and an optical surface (3); the source of optical radiation (15) provides optical radiation (16) that propagates along the core (37) of the optical fibre (1), and unwanted optical radiation (14) that propagates along the cladding (38) that surrounds the core (37); and the absorbing material (2) is in contact with the optical surface (3) over a length (5) of the optical fibre (1). The apparatus is characterized in that: the absorbing material (2) has a refractive index (101) that is higher than a refractive index (100) of the optical surface (3) within a temperature range (102) thus enabling the unwanted optical radiation (14) to pass from the optical fibre (1) into the absorbing material (2) within said temperature range (102); the absorbing material (2) is such that it can absorb at least some of the unwanted optical radiation (14) that enters into it from the optical fibre (1); the absorbing material (2) is such that its temperature increases upon absorption of the unwanted optical radiation (14); and the absorbing material (2) is such that its said refractive index (101) reduces with increasing temperature. This has the effect of limiting the amount of the unwanted optical radiation (14) that can be removed per unit length of optical fibre (1) to a predetermined absorption per unit length (62). Thus the apparatus is such that it is able to remove the unwanted optical radiation (14) up to a power level (12) substantially equal to the product of the predetermined absorption per unit length (62) and the length (5) over which the absorbing material (2) is in contact with the optical surface (3).

    Polypeptides for increasing mutant CFTR channel activity
    7.
    发明授权
    Polypeptides for increasing mutant CFTR channel activity 失效
    用于增加突变CFTR通道活性的多肽

    公开(公告)号：US07264948B2

    公开(公告)日：2007-09-04

    申请号：US10650435

    申请日：2003-08-28

    申请人： Paul D Robbins ,  Raymond Frizzell ,  Zhibao Mi ,  Fei Sun

    发明人： Paul D Robbins ,  Raymond Frizzell ,  Zhibao Mi ,  Fei Sun

    IPC分类号： C07K14/435 ,  C07K14/47 ,  A61K38/00

    CPC分类号： C07K14/4712 ,  A61K38/00 ,  C07K2319/60

    摘要： The present invention provides methods and compositions for enhancing channel activity to the mutant cystic fibrosis trans-membrane conductance regulator protein (CFTR). The compositions of the invention comprise polypeptides containing CFTR sub-domains that are designed to mimic the folding defect of the full length mutant CFTR proteins, resulting in competitive binding to cytoplasmic chaperones such as Hsc/Hsp70 and Hdj2. The methods of the invention comprise transduction, or recombinant expression, of CFTR polypeptides in a cell expressing mutant CFTR. The presence of the CFTR polypeptide results in a dominant effect whereby the CFTR polypeptide competes with the endogenously expressed mutant CFTR for binding to cytoplasmic chaperones such as Hsc/Hsp70 and Hdj2. Mutant CFTR proteins include, but are not limited to, ΔF508 CFTR. The present invention is based on the discovery that reduced binding of cytoplasmic chaperones to the endogenous ΔF508 CFTR, mediated by the presence of CFTR polypeptides, results in restoration of plasma membrane localization and channel activity. The methods and compositions of the invention can be used to restore channel activity in cystic fibrosis subjects carrying genetic defects in the CFTR gene, such as for example, ΔF508 CFTR.

    摘要翻译： 本发明提供了增强对突变型囊性纤维化跨膜传导调节蛋白（CFTR）的通道活性的方法和组合物。 本发明的组合物包含含有CFTR亚结构域的多肽，其被设计为模拟全长突变CFTR蛋白质的折叠缺陷，导致与细胞质伴侣如Hsc / Hsp70和Hdj2的竞争性结合。 本发明的方法包括在表达突变型CFTR的细胞中CFTR多肽的转导或重组表达。 CFTR多肽的存在导致显性效应，由此CFTR多肽与内源表达的突变CFTR竞争结合胞质伴侣如Hsc / Hsp70和Hdj2。 突变CFTR蛋白包括但不限于DeltaF508 CFTR。 本发明基于以下发现：细胞质伴侣与CFTR多肽的存在介导的内源性DeltaF508 CFTR的结合减少导致质膜定位和通道活性的恢复。 本发明的方法和组合物可用于恢复在CFTR基因中携带遗传缺陷的囊性纤维化受试者中的通道活性，例如DeltaF508CFTR。

    Use of recombinant ganoderma immunoregulatory protein (rLZ-8) in preparation of drug for treating melanoma
    9.
    发明申请
    Use of recombinant ganoderma immunoregulatory protein (rLZ-8) in preparation of drug for treating melanoma 审中-公开
    使用重组灵芝免疫调节蛋白（rLZ-8）制备治疗黑色素瘤的药物

    公开(公告)号：US20160129077A1

    公开(公告)日：2016-05-12

    申请号：US14907263

    申请日：2014-06-13

    申请人： Xitian Zhang ,  Fei Sun

    发明人： Xitian Zhang ,  Fei Sun ,  Chongyang Liang

    IPC分类号： A61K38/16

    CPC分类号： A61K38/16

    摘要： A use of recombinant ganoderma immunoregulatory protein (rLZ-8) in a preparation of a drug for treating melanoma is disclosed. By establishing experimental animal models of orthotopic tumors and metastatic tumors, an anti-tumor effect of the rLZ-8 is researched, which indicates that the rLZ-8 significantly inhibits a growth of the orthotopic tumors of the melanoma and a formation of metastases of the melanoma.

    摘要翻译： 公开了重组灵芝免疫调节蛋白（rLZ-8）在制备治疗黑素瘤药物中的应用。 通过建立原位肿瘤和转移性肿瘤的实验动物模型，研究了rLZ-8的抗肿瘤作用，表明rLZ-8显着抑制黑素瘤原位肿瘤的生长，形成转移瘤 黑色素瘤