公开(公告)号：US20070088427A1

公开(公告)日：2007-04-19

申请号：US11252450

申请日：2005-10-17

申请人： Feridun Ozdil ,  Junghwa Cho ,  Joseph Berglund ,  Susan Rea

发明人： Feridun Ozdil ,  Junghwa Cho ,  Joseph Berglund ,  Susan Rea

IPC分类号： A61F2/06

CPC分类号： A61F2/92 ,  A61F2/91 ,  A61F2/958 ,  A61F2220/0008 ,  A61F2230/0054

摘要： An intraluminal stent, an intraluminal stent delivery system, and a method of treating a vascular condition. The stent includes a framework with a plurality of flap portions projecting substantially beyond a central core region. The flap portions are movable from a compressed position and an extended position when the stent is deployed. The system includes a catheter and the intraluminal stent. The method includes positioning an intraluminal stent within a vessel. A plurality of flap portions of the stent is extended from a compressed position into contact with the vessel.

摘要翻译： 管腔内支架，腔内支架输送系统和治疗血管病变的方法。 支架包括具有大致突出超过中心芯区域的多个翼片部分的框架。 当支架展开时，翼片部分可从压缩位置和伸出位置移动。 该系统包括导管和管腔内支架。 该方法包括将管腔内支架定位在血管内。 支架的多个翼片部分从压缩位置延伸以与血管接触。

公开(公告)号：US07749262B2

公开(公告)日：2010-07-06

申请号：US11252450

申请日：2005-10-17

申请人： Feridun Ozdil ,  Junghwa Jenn Cho ,  Joseph Berglund ,  Susan Rea

发明人： Feridun Ozdil ,  Junghwa Jenn Cho ,  Joseph Berglund ,  Susan Rea

IPC分类号： A61F2/06

CPC分类号： A61F2/92 ,  A61F2/91 ,  A61F2/958 ,  A61F2220/0008 ,  A61F2230/0054

摘要： An intraluminal stent, an intraluminal stent delivery system, and a method of treating a vascular condition. The stent includes a framework with a plurality of flap portions projecting substantially beyond a central core region. The flap portions are movable from a compressed position and an extended position when the stent is deployed. The system includes a catheter and the intraluminal stent. The method includes positioning an intraluminal stent within a vessel. A plurality of flap portions of the stent is extended from a compressed position into contact with the vessel.

摘要翻译： 管腔内支架，腔内支架输送系统和治疗血管病变的方法。 支架包括具有大致突出超过中心芯区域的多个翼片部分的框架。 当支架展开时，翼片部分可从压缩位置和伸出位置移动。 该系统包括导管和管腔内支架。 该方法包括将管腔内支架定位在血管内。 支架的多个翼片部分从压缩位置延伸以与血管接触。

公开(公告)号：US20090035351A1

公开(公告)日：2009-02-05

申请号：US12212817

申请日：2008-09-18

申请人： Joseph Berglund ,  Ankit Shah ,  Feridun Ozdil ,  Christopher Bonny

发明人： Joseph Berglund ,  Ankit Shah ,  Feridun Ozdil ,  Christopher Bonny

IPC分类号： A61F2/82

CPC分类号： A61F2/88 ,  A61F2/022 ,  A61F2/82 ,  A61F2/885 ,  A61F2250/003 ,  A61F2250/0035 ,  A61F2250/0068

摘要： A biodegradable implantable device for delivering a drug to a treatment site includes a biodegradable hypotube defining a lumen and at least one drug disposed within the lumen of the hypotube. At least one drug is released from the lumen upon degradation of the biodegradable hypotube. The lumen may be compartmentalized, each compartment containing a different drug. The hypotube may also include a plurality of pores in fluid communication with the compartments providing different drug release profiles.

摘要翻译： 用于将药物递送到治疗部位的可生物降解的可植入装置包括限定内腔的可生物降解的海波管和设置在海波管内腔内的至少一种药物。 在降解可生物降解海波管时，至少有一种药物从内腔释放。 腔可以是间隔的，每个隔室含有不同的药物。 海波管还可以包括与隔室流体连通以提供不同药物释放曲线的多个孔。

公开(公告)号：US20090024209A1

公开(公告)日：2009-01-22

申请号：US11780702

申请日：2007-07-20

申请人： Feridun Ozdil ,  Joseph Berglund

发明人： Feridun Ozdil ,  Joseph Berglund

IPC分类号： A61F2/06

CPC分类号： A61F2/88 ,  A61F2210/0004 ,  A61F2250/003 ,  A61F2250/0035 ,  A61F2250/0068

摘要： An implantable device capable of delivering drugs is disclosed. An example of the device is a stent that comprises at least one hypotube having a lumen and one or more pores. The lumen of the hypotube is configured to retain drugs that can be eluted through the one or more pores after deployment at a treatment site.

摘要翻译： 公开了一种能够输送药物的可植入装置。 该装置的实例是包括至少一个具有内腔和一个或多个孔的海波管的支架。 海波管的管腔被配置为保留在处置部位展开后可以通过一个或多个孔洗脱的药物。

公开(公告)号：US20080306581A1

公开(公告)日：2008-12-11

申请号：US11759420

申请日：2007-06-07

申请人： Joseph Berglund ,  Susan Rea

发明人： Joseph Berglund ,  Susan Rea

IPC分类号： A61F2/06

CPC分类号： A61F2/90 ,  A61F2/88 ,  A61F2002/068 ,  A61F2250/0013

摘要： A stent for implantation within the body of a patient is disclosed. The stent can be formed from one or more stent modules comprising a plurality of stent struts, one or more of which have an inner contour designed for streamlined fluid flow when the stent is implanted within an anatomical passageway of the patient.

摘要翻译： 公开了一种用于植入患者体内的支架。 支架可以由包括多个支架支架的一个或多个支架模块形成，其中一个或多个支架支架具有设计用于当支架植入患者的解剖通道内时流线型流体流动的内部轮廓。

公开(公告)号：US20100256738A1

公开(公告)日：2010-10-07

申请号：US12419531

申请日：2009-04-07

申请人： Joseph Berglund

发明人： Joseph Berglund

IPC分类号： A61F2/82

CPC分类号： A61F2/91 ,  A61F2002/068 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2230/0067

摘要： An implantable flow restrictor device is disclosed for initially restricting, then gradually restoring blood flow through a body vessel after an interventional procedure. A self-expanding annular member having a constricted diameter gives the device a frustoconical configuration that reduces blood flow therethrough upon initial deployment at a treatment site. The annular member is constricted by a plurality of linkages that operate to allow the annular member to gradually expand, thereby transforming the flow restrictor device to a cylindrical configuration that allows unimpeded blood flow therethrough. In one embodiment, expansion of the annular member is achieved via biodegradation of the linkages. In another embodiment, expansion of the annular member is achieved via creep deformation of the linkages. The flow restrictor device may be attached to an endoluminal prosthesis, or may be a separate complementary component that is delivered during an interventional procedure.

公开(公告)号：US20100125323A1

公开(公告)日：2010-05-20

申请号：US12271465

申请日：2008-11-14

申请人： Joseph Berglund ,  Matthew J. Birdsall ,  Lesley Crookall

发明人： Joseph Berglund ,  Matthew J. Birdsall ,  Lesley Crookall

IPC分类号： A61F2/06

CPC分类号： A61L31/148 ,  A61F2/88 ,  A61F2/95 ,  A61F2002/9517 ,  A61F2002/9665 ,  A61F2220/0016

摘要： The coil stent delivery system and method of use includes a stent delivery system including a coil stent; a housing, the housing having a receiver defining a receiver chamber and a sheath defining a sheath lumen, the receiver chamber being in communication with the sheath lumen; and a screw assembly, the screw assembly having a shaft, a helical screw disposed about a distal portion of the shaft, and a drive operably coupled to the shaft. The shaft is disposed in the receiver chamber and the sheath lumen, the helical screw is disposed in the sheath, and the coil stent is disposed about the shaft in the receiver chamber and engages the helical screw. Rotation of the drive moves the coil stent through the sheath lumen.

摘要翻译： 线圈支架输送系统和使用方法包括支架输送系统，其包括线圈支架; 壳体，其具有限定了接收器室的接收器和限定护套管腔的护套，所述接收器腔室与鞘管腔连通; 和螺钉组件，所述螺钉组件具有轴，设置在所述轴的远侧部分周围的螺旋形螺钉以及可操作地联接到所述轴的驱动器。 轴设置在接收器腔室和护套管腔中，螺旋形螺钉设置在护套中，线圈支架围绕接收器腔室中的轴设置并与螺旋形螺钉接合。 驱动器的旋转将线圈支架移动通过鞘管。

公开(公告)号：US09549832B2

公开(公告)日：2017-01-24

申请号：US13457398

申请日：2012-04-26

申请人： Justin Peterson ,  James Mitchell ,  Abby Schlichting ,  Nate Glucklich ,  Joseph Berglund ,  Ya Guo

发明人： Justin Peterson ,  James Mitchell ,  Abby Schlichting ,  Nate Glucklich ,  Joseph Berglund ,  Ya Guo

IPC分类号： A61F2/91 ,  A61L31/16

CPC分类号： A61F2/91 ,  A61F2/82 ,  A61F2240/00 ,  A61F2250/0068 ,  A61L31/16 ,  A61L2420/02

摘要： Methods and apparatus are disclosed for filling a therapeutic substance or drug within a hollow wire that forms a stent. The stent is placed within a chamber housing a fluid drug formulation. During filling, the chamber is maintained at or near the vapor-liquid equilibrium of the solvent of the fluid drug formulation. To fill the stent, a portion of the stent is placed into contact with the fluid drug formulation until a lumenal space defined by the hollow wire is filled with the fluid drug formulation via capillary action. After filling is complete, the stent is retracted such that the stent is no longer in contact with the fluid drug formulation. The solvent vapor pressure within the chamber is reduced to evaporate a solvent of the fluid drug formulation. A wicking means may control transfer of the fluid drug formulation into the stent.

摘要翻译： 公开了用于在形成支架的中空丝内填充治疗物质或药物的方法和装置。 将支架放置在容纳流体药物制剂的腔室内。 在填充期间，室被保持在或接近流体药物制剂的溶剂的气液平衡。 为了填充支架，将支架的一部分放置成与流体药物制剂接触，直到由空心线限定的腔空间通过毛细作用填充流体药物制剂。 填充完成后，支架缩回，使得支架不再与流体药物制剂接触。 室内的溶剂蒸气压降低以蒸发流体药物制剂的溶剂。 芯吸装置可以控制流体药物制剂转移到支架中。

公开(公告)号：US20070191811A1

公开(公告)日：2007-08-16

申请号：US11276023

申请日：2006-02-10

申请人： Joseph Berglund

发明人： Joseph Berglund

IPC分类号： A61M31/00

CPC分类号： A61M25/104 ,  A61M2025/0093 ,  A61M2025/105 ,  A61M2025/1081 ,  A61M2025/1086

摘要： A system and method for treating a vascular condition. The system includes a catheter and an inflatable member operably attached to the catheter. A plurality of detachable microdarts is disposed on the inflatable member. The method includes locating a vulnerable plaque. An inflatable member including a plurality of biodegradable and detachable microdarts is positioned adjacent the vulnerable plaque. The plurality of detachable microdarts is inserted into a vessel wall.

摘要翻译： 用于治疗血管病症的系统和方法。 该系统包括导管和可操作地附接到导管的可充气构件。 多个可拆卸的微型点配置在可充气构件上。 该方法包括定位易损斑块。 包括多个可生物降解和可拆卸微粒的可充气构件位于易损斑块附近。 多个可拆卸的微型点插入血管壁。

公开(公告)号：US08888836B2

公开(公告)日：2014-11-18

申请号：US12419531

申请日：2009-04-07

申请人： Joseph Berglund

发明人： Joseph Berglund

IPC分类号： A61F2/06 ,  A61F2/91

CPC分类号： A61F2/91 ,  A61F2002/068 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2230/0067

摘要： An implantable flow restrictor device is disclosed for initially restricting, then gradually restoring blood flow through a body vessel after an interventional procedure. A self-expanding annular member having a constricted diameter gives the device a frustoconical configuration that reduces blood flow therethrough upon initial deployment at a treatment site. The annular member is constricted by a plurality of linkages that operate to allow the annular member to gradually expand, thereby transforming the flow restrictor device to a cylindrical configuration that allows unimpeded blood flow therethrough. In one embodiment, expansion of the annular member is achieved via biodegradation of the linkages. In another embodiment, expansion of the annular member is achieved via creep deformation of the linkages. The flow restrictor device may be attached to an endoluminal prosthesis, or may be a separate complementary component that is delivered during an interventional procedure.

摘要翻译： 公开了一种可植入式限流装置，用于在介入手术之后最初限制，然后逐渐恢复通过身体血管的血流。 具有收缩直径的自膨胀环形构件使得装置具有截头圆锥形构型，其在处理部位初始部署时减少血流量。 环形构件被多个连接件收缩，其操作以允许环形构件逐渐膨胀，从而将限流装置转换成允许不受阻碍的血液流过其中的圆柱形构型。 在一个实施例中，环形构件的膨胀通过连接件的生物降解实现。 在另一个实施例中，通过连杆的蠕变变形来实现环形构件的膨胀。 限流器装置可以附接到腔内假体，或者可以是在介入手术期间递送的单独的补充部件。