公开(公告)号：US20110008405A1

公开(公告)日：2011-01-13

申请号：US12500359

申请日：2009-07-09

申请人： Matthew J. Birdsall ,  Christopher Storment ,  D.H. Perkins ,  Dustin Thompson

发明人： Matthew J. Birdsall ,  Christopher Storment ,  D.H. Perkins ,  Dustin Thompson

IPC分类号： A61L27/54 ,  B44C1/22

CPC分类号： A61M25/0015 ,  A61B2017/00526 ,  A61L31/022 ,  A61L31/16 ,  A61M25/0012 ,  A61N1/0587

摘要： A method of a forming a hollow, drug-eluting medical device includes providing composite member having an outer member and a core member disposed within a lumen of the outer member. The composite member is shaped into a pattern. Openings are formed through the outer member of the composite member. The composite member is processed to remove the core member from the lumen of the outer member without harming the outer member, leaving a hollow tubular member already formed into the desired pattern. The lumen of the outer member is filled with a therapeutic substance.

摘要翻译： 形成中空药物洗脱医疗装置的方法包括提供具有外部构件和设置在外部构件的内腔内的芯构件的复合构件。 复合构件成形为图案。 通过复合构件的外部构件形成开口。 处理复合构件以从外部构件的内腔移除芯构件而不损害外部构件，留下已经形成为期望图案的中空管状构件。 外部构件的内腔填充有治疗物质。

公开(公告)号：US20090093871A1

公开(公告)日：2009-04-09

申请号：US11868742

申请日：2007-10-08

申请人： Susan Rea ,  Feridun Ozdil ,  Robert Rajalingam ,  Noreen F. Moloney ,  Jeffrey Allen ,  Matthew J. Birdsall ,  Darrel Untereker ,  Jeffrey Gross ,  Mark Dolan

发明人： Susan Rea ,  Feridun Ozdil ,  Robert Rajalingam ,  Noreen F. Moloney ,  Jeffrey Allen ,  Matthew J. Birdsall ,  Darrel Untereker ,  Jeffrey Gross ,  Mark Dolan

IPC分类号： A61F2/06

CPC分类号： A61F2/90 ,  A61F2250/0068

摘要： A system for treating a vascular condition includes a catheter and a stent disposed on the catheter. The stent includes tubing having a wall defining a central lumen and a plurality of holes. The system further includes a therapeutic agent disposed within the central lumen of the tubing. A method of manufacturing a therapeutic agent carrying stent includes inserting a therapeutic agent within a therapeutic agent delivery system into the central lumen of a hollow metal tube and forming a stent framework from the hollow tube.

摘要翻译： 用于治疗血管状态的系统包括导管和设置在导管上的支架。 支架包括具有限定中心腔和多个孔的壁的管。 该系统还包括设置在管的中心腔内的治疗剂。 制造治疗剂携带支架的方法包括将治疗剂递送系统内的治疗剂插入中空金属管的中心腔，并从中空管形成支架框架。

公开(公告)号：US20080319534A1

公开(公告)日：2008-12-25

申请号：US11767308

申请日：2007-06-22

申请人： Matthew J. Birdsall ,  Gianfranco Pellegrini ,  Justin Goshgarian ,  Jeffrey Allen

发明人： Matthew J. Birdsall ,  Gianfranco Pellegrini ,  Justin Goshgarian ,  Jeffrey Allen

IPC分类号： A61F2/06

CPC分类号： A61F2/88 ,  A61F2/915 ,  A61F2002/91508 ,  A61F2002/91558 ,  A61F2220/0058 ,  A61F2250/0036

摘要： A stent includes a central portion having a first waveform. The first waveform is wrapped around a longitudinal axis of the stent at a pitch to define a plurality of helical turns. The stent also includes an end segment connected to one end of the central portion. The end segment has a second waveform that includes a plurality of struts and a plurality of crowns. Each of the plurality of struts has a different length so that peaks of the crowns that define an end of the stent lie within a plane that is substantially perpendicular to the longitudinal axis. Cross-sectional areas of the struts having different lengths vary so that the struts move substantially uniformly during radial contraction and/or radial expansion of the stent.

摘要翻译： 支架包括具有第一波形的中心部分。 第一波形以间距缠绕在支架的纵向轴线上以限定多个螺旋形匝。 支架还包括连接到中心部分的一端的端部段。 端部段具有包括多个支柱和多个冠部的第二波形。 多个支柱中的每一个具有不同的长度，使得限定支架的端部的冠部的顶点位于基本上垂直于纵向轴线的平面内。 具有不同长度的支柱的横截面积变化，使得支柱在支架的径向收缩和/或径向膨胀期间基本均匀地移动。

公开(公告)号：US06989028B2

公开(公告)日：2006-01-24

申请号：US10066302

申请日：2002-01-30

申请人： Randall T. Lashinski ,  Matthew J. Birdsall ,  Michael D. Lesh

发明人： Randall T. Lashinski ,  Matthew J. Birdsall ,  Michael D. Lesh

IPC分类号： A61F2/06

CPC分类号： A61F2/2451

摘要： A medical apparatus and method suitable for remodeling a mitral valve annulus adjacent to the coronary sinus. The apparatus comprises an elongate body having a proximal region and a distal region. Each of the proximal and distal regions is dimensioned to reside completely within the vascular system. The elongate body may be moved from a first configuration for transluminal delivery to at least a portion of the coronary sinus to a second configuration for remodeling the mitral valve annulus proximate the coronary sinus. A forming element may be attached to the elongate body for manipulating the elongate body from the first transluminal configuration to the second remodeling configuration. Further, the elongate body may comprise a tube having a plurality of transverse slots therein.

公开(公告)号：US06520988B1

公开(公告)日：2003-02-18

申请号：US08937130

申请日：1997-09-24

申请人： Antonio Colombo ,  Robert D. Lashinski ,  Matthew J. Birdsall ,  Dennis L. Brooks ,  Philip J. Haarstad ,  James C. Peacock, III

发明人： Antonio Colombo ,  Robert D. Lashinski ,  Matthew J. Birdsall ,  Dennis L. Brooks ,  Philip J. Haarstad ,  James C. Peacock, III

IPC分类号： A61F206

CPC分类号： A61F2/856 ,  A61F2/91 ,  A61F2/915 ,  A61F2/954 ,  A61F2/958 ,  A61F2002/065 ,  A61F2002/91541 ,  A61F2002/91558 ,  A61F2250/0039

摘要： An endolumenal medical device assembly is provided for use in a bifurcation region of a body lumen. An expandable prosthesis, such as a stent, is included in the assembly and is adjustable from a radially collapsed condition to a radially expanded condition. The expandable prosthesis includes a prosthesis passageway and a side port. A dilator or an access device is engaged within the prosthesis passageway and also through the side port while the expandable prosthesis is in the radially collapsed condition. The expandable prosthesis may be positioned in the bifurcation region such that its distal end portion is in a first branch lumen extending from the bifurcation, its proximal end portion is in a common proximal lumen of the bifurcation region, and the side port is aligned with an entrance zone to a second branch lumen extending from the bifurcation. When the expandable prosthesis is so positioned the access device maintains percutaneous translumenal access to the second branch lumen through the prosthesis passageway and the side port while the expandable prosthesis is adjusted from the radially collapsed condition to the radially expanded condition. A dilator may also to expand the bore formed by the side port from an initial inner diameter to a larger expanded inner diameter. A second, lateral expandable prosthesis can also be coupled to the first expandable prosthesis at a location adjacent to the side port and engaged by the dilator or access device extending through the side port.

摘要翻译： 提供了一种用于体腔分叉区域的腔内医疗装置组件。 可扩张假体，例如支架，被包括在组件中，并且可以从径向塌陷状态调节到径向扩张状态。 可扩张假体包括假体通道和侧端口。 扩张器或进入装置接合在假体通道内并且还可以通过侧端口，而可扩张假体处于径向折叠状态。 可扩张假体可以位于分叉区域中，使得其远端部分处于从分叉延伸的第一分支腔中，其近端部分位于分叉区域的共同的近侧内腔中，并且侧端口与 入口区到从分叉延伸的第二分支腔。 当可扩张假体如此定位时，进入装置通过假体通道和侧端口保持对第二分支腔的经皮腔内通路，同时将可扩张假体从径向折叠状态调节到径向扩张状态。 扩张器还可以将由侧口形成的孔从初始内径扩大到较大的扩大内径。 第二横向可膨胀假体还可以在与侧端口相邻的位置处联接到第一可扩张假体，并且通过延伸穿过侧端口的扩张器或进入装置接合。

公开(公告)号：US08205317B2

公开(公告)日：2012-06-26

申请号：US11778430

申请日：2007-07-16

申请人： Matthew J. Birdsall ,  Jeffrey W. Allen

发明人： Matthew J. Birdsall ,  Jeffrey W. Allen

IPC分类号： B23P25/00 ,  A61F2/06

CPC分类号： A61L31/022 ,  A61F2/91 ,  A61F2210/0076 ,  A61F2250/0067 ,  A61F2250/0068 ,  A61L31/146 ,  Y10T29/49885 ,  Y10T29/49995 ,  Y10T29/49996

摘要： A method of manufacturing a stent includes forming a stent blank including a predetermined alloy composition, the alloy composition including at least base element and at least one sacrificial element and forming a stent framework from the stent blank. The method further includes removing at least a portion of the sacrificial element and forming at least one pore based on the removal. A method of manufacturing a vascular treatment system includes forming a stent blank including a predetermined alloy composition including at least one base element and at least one sacrificial element. The method further includes forming a stent framework and removing at least a portion of the sacrificial element. The method also includes forming at least one pore based on the removal, bending the stent framework to a delivery shape, and attaching the bent stent framework including the formed pores to a catheter.

摘要翻译： 制造支架的方法包括形成包括预定合金组成的支架坯料，所述合金组合物至少包括基体元件和至少一个牺牲元件，并从支架坯件形成支架框架。 该方法还包括去除牺牲元件的至少一部分并基于去除形成至少一个孔。 一种制造血管治疗系统的方法包括形成包括至少一个基底元件和至少一个牺牲元件的预定合金组合物的支架坯料。 该方法还包括形成支架框架并去除牺牲元件的至少一部分。 该方法还包括基于去除形成至少一个孔，将支架框架弯曲成输送形状，以及将包括形成的孔的弯曲支架框架附接到导管。

公开(公告)号：US20090287290A1

公开(公告)日：2009-11-19

申请号：US12358084

申请日：2009-01-22

申请人： Patrick E. Macaulay ,  Robert J. Murray ,  Trevor Greenan ,  Timothy R. Ryan ,  Charles Tabor ,  Matthew J. Birdsall ,  Gianfranco Pellegrini

发明人： Patrick E. Macaulay ,  Robert J. Murray ,  Trevor Greenan ,  Timothy R. Ryan ,  Charles Tabor ,  Matthew J. Birdsall ,  Gianfranco Pellegrini

IPC分类号： A61F2/06

CPC分类号： A61F2/2412 ,  A61F2/2418 ,  A61F2/2436 ,  A61F2002/9505 ,  A61F2002/9511 ,  A61F2002/9534 ,  A61F2002/9665 ,  A61F2250/0098

摘要： A delivery system for delivering a stented prosthetic heart valve to a lumen of a patient, the delivery system including a tubular body having a proximal end, a distal end, and a base portion with a plurality of extending elements, wherein each of the extending elements is engageable with a portion of a stent of a prosthetic heart valve. The delivery system further includes a sleeve having an inner area. The sheath is longitudinally moveable relative to the base portion from a first position where the inner area of the sleeve at least partially covers the extending elements of the base portion to a second position where the extending elements are not positioned within the inner area of the sleeve.

摘要翻译： 一种用于将支架假体心脏瓣膜递送到患者的内腔的输送系统，所述输送系统包括具有近端，远端和具有多个延伸元件的基部的管状体，其中每个所述延伸元件 可与假体心脏瓣膜的支架的一部分接合。 输送系统还包括具有内部区域的套筒。 护套从第一位置可相对于基部纵向移动，其中套筒的内部区域至少部分地将基部的延伸元件覆盖到第二位置，在第二位置，延伸元件不位于套筒的内部区域内 。

公开(公告)号：US20090204203A1

公开(公告)日：2009-08-13

申请号：US12027715

申请日：2008-02-07

申请人： Jeffrey Allen ,  Matthew J. Birdsall

发明人： Jeffrey Allen ,  Matthew J. Birdsall

IPC分类号： A61F2/82

CPC分类号： A61F2/915 ,  A61F2210/0004 ,  A61F2230/0013 ,  A61F2250/003 ,  A61F2250/0036 ,  A61F2250/0098

摘要： A bioabsorbable stent includes one or more radiopaque markers. The stent body may include a generally cylindrical body portion and a marker support for receiving the one or more marker(s). The marker support may be connected to an end of the body portion, or may be an integral portion of the body portion. By selectively controlling dissolution of the biodegradable material of the marker support, the marker support will remain intact for a sufficient time to allow for the marker to endothelialize and therefore prevent the marker from dislodging and embolizing. The controlled dissolution may be accomplished via one or more of the following mechanisms, including increasing the cross-sectional thickness of the marker support, passivating or oxidizing the marker support, utilizing a different, slower absorbing material for the marker support, utilizing a bioabsorbable polymeric coating on the marker support, or protecting the marker support with a sacrificial anode.

摘要翻译： 生物可吸收支架包括一个或多个不透射线的标记。 支架主体可以包括大致圆柱形主体部分和用于接收一个或多个标记的标记支撑件。 标记支撑件可以连接到主体部分的端部，或者可以是主体部分的整体部分。 通过选择性地控制标记载体的可生物降解材料的溶解，标记物载体将保持完整的足够的时间以允许标记物内皮化并因此防止标记物移出和栓塞。 受控的溶解可以通过一种或多种以下机制来实现，包括使用生物可吸收聚合物的标记载体的不同的较慢的吸收材料来增加标记物载体的横截面厚度，钝化或氧化标记物载体 涂覆在标记支撑件上，或用牺牲阳极保护标记支撑件。

公开(公告)号：US20090192583A1

公开(公告)日：2009-07-30

申请号：US12021010

申请日：2008-01-28

申请人： Eugene Tedeschi ,  Richard Francis ,  Matthew J. Birdsall

发明人： Eugene Tedeschi ,  Richard Francis ,  Matthew J. Birdsall

IPC分类号： A61F2/84 ,  A61F2/82

CPC分类号： A61L31/10 ,  A61L31/16 ,  A61L2300/00 ,  A61L2300/602 ,  A61L2420/08

摘要： A system for treating a vascular condition comprises a therapeutic agent eluting stent having a layered coating on the stent framework. The coating releases therapeutically effective amounts of one or more therapeutic agents in and ordered sequence and over a selected time period. Another embodiment of the invention includes a method of treating a vascular condition by placing a stent having a layered coating at a treatment site and delivering a therapeutically effective amount of one or more therapeutic agents at the treatment site in an ordered sequence and over a selected time period.

摘要翻译： 用于治疗血管病症的系统包括在支架框架上具有层状涂层的治疗剂洗脱支架。 涂层释放治疗有效量的一种或多种治疗剂，并且在有选择的时间内排序和排序。 本发明的另一个实施方案包括通过将具有层状涂层的支架放置在治疗部位并以有序序列并在选定时间内在治疗部位递送治疗有效量的一种或多种治疗剂来治疗血管病症的方法 期。

公开(公告)号：US07524331B2

公开(公告)日：2009-04-28

申请号：US11278925

申请日：2006-04-06

申请人： Matthew J. Birdsall

发明人： Matthew J. Birdsall

IPC分类号： A61F2/06

CPC分类号： A61F2/2412 ,  A61F2/06 ,  A61F2/2418 ,  A61F2/2436 ,  A61F2/2475 ,  A61F2002/077 ,  A61F2210/0061 ,  A61F2250/0069 ,  A61L27/303 ,  A61L27/34

摘要： A system for treating abnormalities of the right ventricular outflow tract includes a prosthetic valve device having a barrier material contacting at least a portion of the outer surface of the valve device. One embodiment of the invention includes a barrier member attached to the exterior surface of the valve device. Another embodiment includes a barrier material that is injected within the vascular system. Yet another embodiment of the invention includes a method for replacing a pulmonary valve that includes forming a barrier around the outer surface of a replacement valve and preventing blood flow around the replacement valve.

摘要翻译： 用于治疗右心室流出道的异常的系统包括具有接触阀装置的外表面的至少一部分的阻挡材料的人造瓣膜装置。 本发明的一个实施例包括附接到阀装置的外表面的阻挡构件。 另一个实施方案包括注入血管系统内的阻挡材料。 本发明的另一个实施例包括一种用于替换肺动脉瓣的方法，该肺动脉瓣包括在置换瓣膜的外表面周围形成屏障并防止置换瓣膜周围的血液流动。