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公开(公告)号：US08835659B2
公开(公告)日：2014-09-16
申请号：US13695971
申请日：2011-05-10
申请人： Fernando Pedro Cossio Mora , Leire Lidia Arias Echeverría , Yosu Ion Vara Zalazar , Eneko Aldaba Arévalo , Eider San Sebastián Larzabal , Aizpea Zubia Olascoaga
发明人： Fernando Pedro Cossio Mora , Leire Lidia Arias Echeverría , Yosu Ion Vara Zalazar , Eneko Aldaba Arévalo , Eider San Sebastián Larzabal , Aizpea Zubia Olascoaga
IPC分类号： C07D307/00 , C07D307/87 , C07D307/93 , C07D317/00 , C07D323/02 , A01N43/08 , A61K31/34 , C07D307/81 , C07D307/82 , C07D307/92 , C07D405/04 , C07D407/04 , C07D307/79 , C07D307/80
CPC分类号： C07D307/80 , C07D307/79 , C07D307/81 , C07D307/82 , C07D307/92 , C07D405/04 , C07D407/04
摘要： The present invention refers to compounds of formula (I): as well as to a method for their preparation, pharmaceutical compositions comprising the same, and use thereof for the treatment and/or chemoprevention of cancer, aging related diseases or processes, diabetes and neurodegenerative diseases.
摘要翻译： 本发明涉及式（I）化合物：以及其制备方法，包含其的药物组合物及其用于治疗和/或化学预防癌症，老化相关疾病或过程的用途，糖尿病和神经变性 疾病
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公开(公告)号：US20130217730A1
公开(公告)日：2013-08-22
申请号：US13695971
申请日：2011-05-10
申请人： Fernando Pedro Cossio Mora , Leire Lidia Arias Echeverría , Yosu Ion Vara Zalazar , Eneko Aldaba Arévalo , Eider San Sebastián Larzabal , Aizpea Zubia Olascoaga
发明人： Fernando Pedro Cossio Mora , Leire Lidia Arias Echeverría , Yosu Ion Vara Zalazar , Eneko Aldaba Arévalo , Eider San Sebastián Larzabal , Aizpea Zubia Olascoaga
IPC分类号： C07D307/80 , C07D307/82 , C07D307/81 , C07D405/04 , C07D307/79
CPC分类号： C07D307/80 , C07D307/79 , C07D307/81 , C07D307/82 , C07D307/92 , C07D405/04 , C07D407/04
摘要： The present invention refers to compounds of formula (I): as well as to a method for their preparation, pharmaceutical compositions comprising the same, and use thereof for the treatment and/or chemoprevention of cancer, aging related diseases or processes, diabetes and neurodegenerative diseases.
摘要翻译： 本发明涉及式（I）化合物：以及其制备方法，包含其的药物组合物及其用于治疗和/或化学预防癌症，老化相关疾病或过程的用途，糖尿病和神经变性 疾病
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公开(公告)号：US20080262073A1
公开(公告)日：2008-10-23
申请号：US10571497
申请日：2005-12-27
申请人： Fernando Pedro Cossio Mora , Manel Esteller Badosa , Aizpea Zubia Olascoaga , Dorleta Otaegui Ansa
发明人： Fernando Pedro Cossio Mora , Manel Esteller Badosa , Aizpea Zubia Olascoaga , Dorleta Otaegui Ansa
IPC分类号： A61K31/4025 , A61K31/40 , C07D207/30 , C07D409/02 , A61P35/00
CPC分类号： C07D207/42 , C07D207/34
摘要： The invention describes new compounds derived from formula I pyrroles, methods for obtaining them and their application as drugs in pharmaceutical compositions for the treatment of cancer due to their inhibitory activity on certain histone deacetylases.
摘要翻译： 本发明描述了衍生自式I吡咯的新化合物，其获得方法及其作为药物在药物组合物中的应用，因为它们对某些组蛋白脱乙酰酶具有抑制活性，因此用于治疗癌症。
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公开(公告)号：US07638550B2
公开(公告)日：2009-12-29
申请号：US10571497
申请日：2005-12-27
申请人： Fernando Pedro Cossio Mora , Manel Esteller Badosa , Aizpea Zubia Olascoaga , Dorleta Otaegui Ansa
发明人： Fernando Pedro Cossio Mora , Manel Esteller Badosa , Aizpea Zubia Olascoaga , Dorleta Otaegui Ansa
IPC分类号： A61K31/4025 , C07D333/10 , C07D295/00
CPC分类号： C07D207/42 , C07D207/34
摘要： The invention describes new compounds derived from formula I pyrroles, methods for obtaining them and their application as drugs in pharmaceutical compositions for the treatment of cancer due to their inhibitory activity on certain histone deacetylases.
摘要翻译： 本发明描述了衍生自式I吡咯的新化合物，其获得方法及其作为药物在药物组合物中的应用，因为它们对某些组蛋白脱乙酰酶具有抑制活性，因此用于治疗癌症。
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公开(公告)号：US07943660B2
公开(公告)日：2011-05-17
申请号：US12093180
申请日：2005-11-14
申请人： Natalia Gallot Escobal , Fernando Vidal Vanaclocha , Fernando Pedro Cossio Mora , Miren Lorea Mendoza Arteche , Aizpea Zubia Olascoaga , Maria Valcarcel Cuesta , Yosu Ion Vara Salazar , Miren Sorne Solaun Aguirre , Jose Javier Lopez Pestana , Eider San Sebastian Larzabal
发明人： Natalia Gallot Escobal , Fernando Vidal Vanaclocha , Fernando Pedro Cossio Mora , Miren Lorea Mendoza Arteche , Aizpea Zubia Olascoaga , Maria Valcarcel Cuesta , Yosu Ion Vara Salazar , Miren Sorne Solaun Aguirre , Jose Javier Lopez Pestana , Eider San Sebastian Larzabal
IPC分类号： A61K31/40 , C07D207/12 , A61P35/04
CPC分类号： C07D409/04 , C07D207/16 , C07D401/04 , C07D405/04
摘要： The invention relates to the treatment of disorders or diseases mediated by LFA-1/ICAM-1 molecular interaction. This is based on the use of novel chemical compounds capable of inhibiting said interaction, and more particularly, to pharmaceutical compositions containing these compounds.
摘要翻译： 本发明涉及由LFA-1 / ICAM-1分子相互作用介导的疾病或疾病的治疗。 这是基于能够抑制所述相互作用的新型化合物的使用，更具体地说，涉及含有这些化合物的药物组合物。
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6.发明申请公开(公告)号：US20080249157A1
公开(公告)日：2008-10-09
申请号：US12093180
申请日：2005-11-14
申请人： Fernando Pedro Cossio Mora , Eider San Sebastian Larzabal , Miren Lorea Mendoza Arteche , Aizpea Zubia Olascoaga , Maria Valcarcel Cuesta , Yosu Ion Vara Salazar , Miren Sorne Solaun Aguirre , Jose Javier Lopez Pestana , Natalia Gallot Escobal , Fernando Vidal Vanaclocha
发明人： Fernando Pedro Cossio Mora , Eider San Sebastian Larzabal , Miren Lorea Mendoza Arteche , Aizpea Zubia Olascoaga , Maria Valcarcel Cuesta , Yosu Ion Vara Salazar , Miren Sorne Solaun Aguirre , Jose Javier Lopez Pestana , Natalia Gallot Escobal , Fernando Vidal Vanaclocha
IPC分类号： A61K31/40 , C07D207/12 , A61P35/04 , A61P37/00 , A61P29/00
CPC分类号： C07D409/04 , C07D207/16 , C07D401/04 , C07D405/04
摘要： The invention relates to the treatment of disorders or diseases mediated by LFA-1/ICAM-1 molecular interaction. This is based on the use of novel chemical compounds capable of inhibiting said interaction, and more particularly, to pharmaceutical compositions containing these compounds.
摘要翻译： 本发明涉及由LFA-1 / ICAM-1分子相互作用介导的疾病或疾病的治疗。 这是基于能够抑制所述相互作用的新型化合物的使用，更具体地说，涉及含有这些化合物的药物组合物。
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