公开(公告)号：US20180094281A1

公开(公告)日：2018-04-05

申请号：US15564671

申请日：2016-04-11

申请人： Firmenich SA

发明人： Michel SCHALK ,  Fabienne DEGUERRY ,  Pan LI ,  Xiufeng HE ,  Qi WANG

IPC分类号： C12P5/00 ,  C12N9/88

CPC分类号： C12P5/007 ,  C12N9/88 ,  C12Y402/03039 ,  C12Y402/03079

摘要： Provided herein is an isolated polypeptide from Juniperus virginiana, Platycladus orientalis ‘Beverleyensis’ or Platycladus orientalis comprising a (+)-cedrol or a (−)-thujopsene synthase. Further provided herein is an isolated nucleic acid molecule from Juniperus virginiana, Platycladus orientalis ‘Beverleyensis’ or Platycladus orientalis encoding a (+)-cedrol or (−)-thujopsene synthase. Further provided herein are methods of producing (+)-cedrol or (−)-thujopsene.

公开(公告)号：US20210310031A1

公开(公告)日：2021-10-07

申请号：US17271474

申请日：2019-10-14

申请人： FIRMENICH SA

发明人： Daniel SOLIS ESCALANTE ,  Christian GÖRNER ,  Laurent DAVIET ,  Qi WANG

IPC分类号： C12P7/62 ,  C12P7/02

摘要： Described herein are novel methods for the acetyl transferase-catalyzed production of drimanyl-acetate compounds by the acetylation of the respective drimanyl alcohol sources performed in vitro or in vivo. Also described herein is the identification of enzymes having corresponding acetyl transferase activity from different microbial and plant sources. Also described herein is the provision of enzyme mutants derived from the newly identified enzymes. Further described herein is the provision of corresponding coding sequences of such enzymes and mutants, recombinant vectors, and recombinant host cells suitable for the production of such acetyl transferases and mutants and for performing the novel production methods of drimanyl acetate compounds. Still further described herein is a method of using such drimanyl acetates as intermediates for the production of odorant, flavor or fragrance or insect/pest control ingredients.