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公开(公告)号：US20210069335A1
公开(公告)日：2021-03-11
申请号：US17061018
申请日：2020-10-01
发明人： Dov Tamarkin , Elana Gazal , Yohan Hazot , David Schuz , Irakliy Papiashvili
IPC分类号： A61K47/44 , A61K47/06 , A61K9/00 , A61K9/12 , A61K8/31 , A61Q17/04 , A61Q19/00 , A61Q19/10 , A61K31/137 , A61K31/192 , A61K31/4164 , A61K31/57 , A61K31/573 , A61K31/593 , A61K31/65 , A61K8/34 , A61K8/36 , A61K47/10 , A61K47/12 , A61K45/06 , A61K47/02 , A61K47/24
摘要： The present disclosure relates generally to compositions for cosmetic or pharmaceutical application. The compositions include a carrier and rheology modulators.APP
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公开(公告)号：US20200261586A1
公开(公告)日：2020-08-20
申请号：US16805201
申请日：2020-02-28
发明人： Dov Tamarkin , Elana Gazal , Irakliy Papiashvili , Yohan Hazot , David Schuz , Rita Keynan
IPC分类号： A61K47/44 , A61K9/12 , A61K47/24 , A61K47/02 , A61K45/06 , A61K47/12 , A61K47/10 , A61K8/36 , A61K8/34 , A61K31/65 , A61K31/593 , A61K31/573 , A61K31/57 , A61K31/4164 , A61K31/192 , A61K31/137 , A61Q19/10 , A61Q19/00 , A61Q17/04 , A61K8/31 , A61K9/00 , A61K47/06
摘要： A topical therapeutic hydrophobic breakable composition includes a carrier comprising (a) about 60% to about 99% by weight of at least one hydrophobic oil; (b) at least one viscosity-modifying agents selected from the group consisting of a fatty alcohol, a fatty acid and a wax; and (c) a tetracycline antibiotic, characterized in that at least part of the tetracycline antibiotic is suspended in the composition; the viscosity of the composition is at least about 30% higher than the viscosity of the carrier without the tetracycline antibiotic; and is higher than the viscosity of the hydrophobic oil and the tetracycline antibiotic without the viscosity modifying agents. The tetracycline is chemically stable in the composition for at least six months; wherein more than about 90% of the tetracycline has not broken down. The composition is packaged as a breakable foam that breaks easily upon application of shear force.
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3.发明授权公开(公告)号：US10238746B2
公开(公告)日：2019-03-26
申请号：US14850655
申请日：2015-09-10
发明人： Dov Tamarkin , Elana Gazal , Irakliy Papiashvili , Yohan Hazot , David Schuz , Rita Keynan
IPC分类号： A61K47/44 , A61K8/31 , A61K47/06 , A61K9/12 , A61K47/02 , A61K47/10 , A61K8/36 , A61K47/12 , A61K8/34 , A61K9/00 , A61Q19/00 , A61K31/65 , A61K31/4164 , A61K31/57 , A61K31/573 , A61K31/593 , A61K31/137 , A61K31/192 , A61K45/06 , A61K47/24 , A61Q17/04 , A61Q19/10
摘要： A substantially surface active agent tree composition which includes a hydrophobic solvent, and/or a petrolatm, a paraffin wax and/or a fatty alcohol, a fatty acid and/or a wax and/or shea butter, with and without a propellant. A substantially surface active agent free composition, further comprising, a tetracycline antibiotic, or a vitamin D derivative, or one or more other active agents. A method of treatment using a substantially surface active agent tree composition.
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4.发明申请SURFACTANT-FREE WATER-FREE FOAMABLE COMPOSITIONS, BREAKABLE FOAMS AND GELS AND THEIR USES 审中-公开无表面活性剂的无水可泡沫组合物，可破碎的水泥和凝胶及其用途公开(公告)号：US20150196570A1
公开(公告)日：2015-07-16
申请号：US14577659
申请日：2014-12-19
发明人： Dov Tamarkin , Elana Gazal , Irakliy Papiashvili , Yohan Hazot , David Schuz , Rita Keynan
IPC分类号： A61K31/65
CPC分类号： A61K47/44 , A61K8/31 , A61K8/342 , A61K8/361 , A61K9/0014 , A61K9/0048 , A61K9/12 , A61K9/122 , A61K9/124 , A61K31/137 , A61K31/192 , A61K31/4164 , A61K31/57 , A61K31/573 , A61K31/593 , A61K31/65 , A61K45/06 , A61K47/02 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/24 , A61K2800/31 , A61K2800/33 , A61Q17/04 , A61Q19/00 , A61Q19/10
摘要： A substantially surface active agent free composition which includes a hydrophobic solvent, and/or a petrolatum, a paraffin wax and/or a fatty alcohol, a fatty acid and/or a wax and/or shea butter, with and without a propellant. A substantially surface active agent free composition, further comprising, a tetracycline antibiotic, or a vitamin D derivative, or one or more other active agents. A method of treatment using a substantially surface active agent free composition.
摘要翻译： 一种基本上无表面活性剂的组合物，其包含疏水性溶剂和/或凡士林，石蜡和/或脂肪醇，脂肪酸和/或蜡和/或乳木果油，具有和不具有推进剂。 一种基本上无表面活性剂的组合物，还包含四环素抗生素或维生素D衍生物，或一种或多种其它活性剂。 使用基本上无表面活性剂的组合物的治疗方法。
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公开(公告)号：US08865139B1
公开(公告)日：2014-10-21
申请号：US14327040
申请日：2014-07-09
发明人： Dov Tamarkin , Elana Gazal , Irakliy Papiashvili , Yohan Hazot , David Schuz , Rita Keynan
IPC分类号： A61K8/18 , A61K35/50 , A61K31/65 , C07C50/36 , C07C237/26 , A61K47/02 , A61K47/12 , A61K9/12 , A61K47/10 , A61K45/06 , A61K47/44 , A61K47/24
CPC分类号： A61K47/44 , A61K8/31 , A61K8/342 , A61K8/361 , A61K9/0014 , A61K9/0048 , A61K9/12 , A61K9/122 , A61K9/124 , A61K31/137 , A61K31/192 , A61K31/4164 , A61K31/57 , A61K31/573 , A61K31/593 , A61K31/65 , A61K45/06 , A61K47/02 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/24 , A61K2800/31 , A61K2800/33 , A61Q17/04 , A61Q19/00 , A61Q19/10
摘要： A topical therapeutic hydrophobic breakable composition includes a carrier comprising (a) about 60% to about 99% by weight of at least one hydrophobic oil; (b) at least one viscosity-modifying agents selected from the group consisting of a fatty alcohol, a fatty acid and a wax; and (c) a tetracycline antibiotic, characterized in that at least part of the tetracycline antibiotic is suspended in the composition; the viscosity of the composition is at least about 30% higher than the viscosity of the carrier without the tetracycline antibiotic; and is higher than the viscosity of the hydrophobic oil and the tetracycline antibiotic without the viscosity modifying agents. The tetracycline is chemically stable in the composition for at least six months; wherein more than about 90% of the tetracycline has not broken down. The composition is packaged as a breakable foam that breaks easily upon application of shear force.
摘要翻译： 一种局部治疗疏水性可破坏组合物包括载体，其包含（a）约60％至约99％重量的至少一种疏水性油; （b）至少一种选自脂肪醇，脂肪酸和蜡的粘度调节剂; 和（c）四环素抗生素，其特征在于至少部分四环素抗生素悬浮于组合物中; 组合物的粘度比没有四环素抗生素的载体的粘度高至少约30％; 并且高于没有粘度改性剂的疏水性油和四环素类抗生素的粘度。 四环素在组合物中化学稳定至少六个月; 其中大于约90％的四环素未分解。 该组合物包装成易碎泡沫，在施加剪切力时容易破裂。
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公开(公告)号：US20210015928A1
公开(公告)日：2021-01-21
申请号：US17037070
申请日：2020-09-29
发明人： Dov Tamarkin , Elana Gazal , Yohan Hazot , David Schuz , Irakliy Papiashvili
IPC分类号： A61K47/44 , A61K47/06 , A61K9/00 , A61K9/12 , A61K8/31 , A61Q17/04 , A61Q19/00 , A61Q19/10 , A61K31/137 , A61K31/192 , A61K31/4164 , A61K31/57 , A61K31/573 , A61K31/593 , A61K31/65 , A61K8/34 , A61K8/36 , A61K47/10 , A61K47/12 , A61K45/06 , A61K47/02 , A61K47/24
摘要： The present disclosure relates generally to compositions for cosmetic or pharmaceutical application. The compositions include a carrier and rheology modulators.
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公开(公告)号：US20180193468A1
公开(公告)日：2018-07-12
申请号：US15913574
申请日：2018-03-06
发明人： Dov Tamarkin , Elana Gazal , Irakliy Papiashvili , Yohan Hazot , David Schuz , Rita Keynan
IPC分类号： A61K47/44 , A61Q19/10 , A61Q17/04 , A61K47/24 , A61K47/12 , A61K47/10 , A61K47/06 , A61K47/02 , A61K45/06 , A61K31/65 , A61K31/593 , A61K31/573 , A61K31/57 , A61K31/4164 , A61K31/192 , A61K31/137 , A61K9/12 , A61K9/00 , A61K8/36 , A61K8/34 , A61K8/31 , A61Q19/00
CPC分类号： A61K47/44 , A61K8/31 , A61K8/342 , A61K8/361 , A61K9/0014 , A61K9/0048 , A61K9/12 , A61K9/122 , A61K9/124 , A61K31/137 , A61K31/192 , A61K31/4164 , A61K31/57 , A61K31/573 , A61K31/593 , A61K31/65 , A61K45/06 , A61K47/02 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/24 , A61K2800/31 , A61K2800/33 , A61Q17/04 , A61Q19/00 , A61Q19/10
摘要： A topical therapeutic hydrophobic breakable composition includes a carrier comprising (a) about 60% to about 90% by weight of at least one hydrophobic oil; (b) at least one viscosity-modifying agents selected from the group consisting of a fatty alcohol, a fatty acid and a wax; and (c) a tetracycline antibiotic, characterized in that at least part of the tetracycline antibiotic is suspended in the composition; the viscosity of the composition is at least about 30% higher than the viscosity of the carrier without the tetracycline antibiotic; and is higher than the viscosity of the hydrophobic oil and the tetracycline antibiotic without the viscosity modifying agents. The tetracycline is chemically stable to the composition for at least six months; wherein more than about 90% of the tetracycline has not broken down. The composition is packaged as a breakable foam that breaks easily upon application of shear force.
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公开(公告)号：US09675700B2
公开(公告)日：2017-06-13
申请号：US14595882
申请日：2015-01-13
发明人： Dov Tamarkin , Elana Gazal , Irakliy Papiashvili , Yohan Hazot , David Schuz , Rita Keynan
IPC分类号： A61K8/18 , A61K35/50 , A61K31/65 , C07C50/36 , C07C237/26 , A61K47/44 , A61K47/06 , A61K9/00 , A61K9/12 , A61K31/4164 , A61K31/57 , A61K31/573 , A61K31/593 , A61K8/34 , A61K8/36 , A61K47/10 , A61K47/12 , A61K31/137 , A61K31/192 , A61K45/06 , A61K47/02 , A61K47/24 , A61K8/31 , A61Q17/04 , A61Q19/00 , A61Q19/10
CPC分类号： A61K47/44 , A61K8/31 , A61K8/342 , A61K8/361 , A61K9/0014 , A61K9/0048 , A61K9/12 , A61K9/122 , A61K9/124 , A61K31/137 , A61K31/192 , A61K31/4164 , A61K31/57 , A61K31/573 , A61K31/593 , A61K31/65 , A61K45/06 , A61K47/02 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/24 , A61K2800/31 , A61K2800/33 , A61Q17/04 , A61Q19/00 , A61Q19/10
摘要： A topical therapeutic hydrophobic breakable composition includes a carrier comprising, (a) about 60% to about 99% by weight of at least one hydrophobic oil; (b) at least one viscosity-modifying agents selected from the group consisting of a fatty alcohol, a fatty acid and a wax; and (c) a tetracycline antibiotic, characterized in that at least part of the tetracycline antibiotic is suspended in the composition; the viscosity of the composition is at least about 30% higher than the viscosity of the carrier without the tetracycline antibiotic; and is higher than the viscosity of the hydrophobic oil and the tetracycline antibiotic without the viscosity modifying agents. The tetracycline is chemically stable in the composition for at least six months; wherein more than about 90% of the tetracycline has not broken down. The composition is packaged as a breakable foam that breaks easily upon application of shear force.
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公开(公告)号：US20150056149A1
公开(公告)日：2015-02-26
申请号：US14469792
申请日：2014-08-27
发明人： Dov Tamarkin , Elana Gazal , Irakliy Papiashvili , Yohan Hazot , David Schuz , Rita Keynan
CPC分类号： A61K47/44 , A61K8/31 , A61K8/342 , A61K8/361 , A61K9/0014 , A61K9/0048 , A61K9/12 , A61K9/122 , A61K9/124 , A61K31/137 , A61K31/192 , A61K31/4164 , A61K31/57 , A61K31/573 , A61K31/593 , A61K31/65 , A61K45/06 , A61K47/02 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/24 , A61K2800/31 , A61K2800/33 , A61Q17/04 , A61Q19/00 , A61Q19/10
摘要： A topical therapeutic hydrophobic breakable composition includes a carrier comprising (a) about 60% to about 99% by weight of at least one hydrophobic oil; (b) at least one viscosity-modifying agents selected from the group consisting of a fatty alcohol, a fatty acid and a wax; and (c) a tetracycline antibiotic, characterized in that at least part of the tetracycline antibiotic is suspended in the composition; the viscosity of the composition is at least about 30% higher than the viscosity of the carrier without the tetracycline antibiotic; and is higher than the viscosity of the hydrophobic oil and the tetracycline antibiotic without the viscosity modifying agents. The tetracycline is chemically stable in the composition for at least six months; wherein more than about 90% of the tetracycline has not broken down. The composition is packaged as a breakable foam that breaks easily upon application of shear force.
摘要翻译： 一种局部治疗疏水性可破坏组合物包括载体，其包含（a）约60％至约99％重量的至少一种疏水性油; （b）至少一种选自脂肪醇，脂肪酸和蜡的粘度调节剂; 和（c）四环素抗生素，其特征在于至少部分四环素抗生素悬浮于组合物中; 组合物的粘度比没有四环素抗生素的载体的粘度高至少约30％; 并且高于没有粘度改性剂的疏水性油和四环素类抗生素的粘度。 四环素在组合物中化学稳定至少六个月; 其中大于约90％的四环素未分解。 该组合物包装成易碎泡沫，在施加剪切力时容易破裂。
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公开(公告)号：US20140328770A1
公开(公告)日：2014-11-06
申请号：US14327040
申请日：2014-07-09
发明人： Dov Tamarkin , Elana Gazal , Irakliy Papiashvili , Yohan Hazot , David Schuz , Rita Keynan
IPC分类号： A61K47/44 , A61K9/12 , A61K47/02 , A61K47/24 , A61K47/10 , A61K47/12 , A61K31/65 , A61K45/06
CPC分类号： A61K47/44 , A61K8/31 , A61K8/342 , A61K8/361 , A61K9/0014 , A61K9/0048 , A61K9/12 , A61K9/122 , A61K9/124 , A61K31/137 , A61K31/192 , A61K31/4164 , A61K31/57 , A61K31/573 , A61K31/593 , A61K31/65 , A61K45/06 , A61K47/02 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/24 , A61K2800/31 , A61K2800/33 , A61Q17/04 , A61Q19/00 , A61Q19/10
摘要： A topical therapeutic hydrophobic breakable composition includes a carrier comprising (a) about 60% to about 99% by weight of at least one hydrophobic oil; (b) at least one viscosity-modifying agents selected from the group consisting of a fatty alcohol, a fatty acid and a wax; and (c) a tetracycline antibiotic, characterized in that at least part of the tetracycline antibiotic is suspended in the composition; the viscosity of the composition is at least about 30% higher than the viscosity of the carrier without the tetracycline antibiotic; and is higher than the viscosity of the hydrophobic oil and the tetracycline antibiotic without the viscosity modifying agents. The tetracycline is chemically stable in the composition for at least six months; wherein more than about 90% of the tetracycline has not broken down. The composition is packaged as a breakable foam that breaks easily upon application of shear force.
摘要翻译： 一种局部治疗疏水性可破坏组合物包括载体，其包含（a）约60％至约99％重量的至少一种疏水性油; （b）至少一种选自脂肪醇，脂肪酸和蜡的粘度调节剂; 和（c）四环素抗生素，其特征在于至少部分四环素抗生素悬浮于组合物中; 组合物的粘度比没有四环素抗生素的载体的粘度高至少约30％; 并且高于没有粘度改性剂的疏水性油和四环素类抗生素的粘度。 四环素在组合物中化学稳定至少六个月; 其中大于约90％的四环素未分解。 该组合物包装成易碎泡沫，在施加剪切力时容易破裂。
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