公开(公告)号：US11033491B2

公开(公告)日：2021-06-15

申请号：US17072243

申请日：2020-10-16

申请人： Foamix Pharmaceuticals Ltd.

发明人： Dov Tamarkin ,  Doron Friedman ,  Tal Berman ,  Enbal Ziv ,  David Schuz

IPC分类号： A61K9/00 ,  A01N25/16 ,  A61K8/34 ,  A61K8/42 ,  A61K8/92 ,  A61K8/73 ,  A61Q17/02 ,  A61K8/81 ,  A61K8/87 ,  A61Q19/00 ,  A61K8/362 ,  A61K8/37 ,  A61K8/49 ,  A61K8/86 ,  A61K8/04 ,  A61K9/12 ,  A61Q17/04 ,  A61Q19/02 ,  A61Q19/08

摘要： The present invention teaches a foamable pharmaceutical carrier comprising a benefit agent, selected from the group consisting of a dicarboxylic acid and a dicarboxylic acid ester; a stabilizer selected from the group consisting of at least one surface-active agent; at least one polymeric agent and mixtures thereof; a solvent selected from the group consisting of water, a hydrophilic solvent, a hydrophobic solvent, a potent solvent, a polar solvent, a silicone, an emollient, and mixtures thereof, wherein the benefit agent, stabilizer and solvent are selected to provide a composition that is substantially resistant to aging and to phase separation and or can substantially stabilize other active ingredients. The invention further relates to a foamable composition further containing a liquefied hydrocarbon gas propellant.

公开(公告)号：US20210069335A1

公开(公告)日：2021-03-11

申请号：US17061018

申请日：2020-10-01

申请人： Foamix Pharmaceuticals Ltd.

发明人： Dov Tamarkin ,  Elana Gazal ,  Yohan Hazot ,  David Schuz ,  Irakliy Papiashvili

IPC分类号： A61K47/44 ,  A61K47/06 ,  A61K9/00 ,  A61K9/12 ,  A61K8/31 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/10 ,  A61K31/137 ,  A61K31/192 ,  A61K31/4164 ,  A61K31/57 ,  A61K31/573 ,  A61K31/593 ,  A61K31/65 ,  A61K8/34 ,  A61K8/36 ,  A61K47/10 ,  A61K47/12 ,  A61K45/06 ,  A61K47/02 ,  A61K47/24

摘要： The present disclosure relates generally to compositions for cosmetic or pharmaceutical application. The compositions include a carrier and rheology modulators.APP

公开(公告)号：US20200261586A1

公开(公告)日：2020-08-20

申请号：US16805201

申请日：2020-02-28

申请人： Foamix Pharmaceuticals Ltd.

发明人： Dov Tamarkin ,  Elana Gazal ,  Irakliy Papiashvili ,  Yohan Hazot ,  David Schuz ,  Rita Keynan

IPC分类号： A61K47/44 ,  A61K9/12 ,  A61K47/24 ,  A61K47/02 ,  A61K45/06 ,  A61K47/12 ,  A61K47/10 ,  A61K8/36 ,  A61K8/34 ,  A61K31/65 ,  A61K31/593 ,  A61K31/573 ,  A61K31/57 ,  A61K31/4164 ,  A61K31/192 ,  A61K31/137 ,  A61Q19/10 ,  A61Q19/00 ,  A61Q17/04 ,  A61K8/31 ,  A61K9/00 ,  A61K47/06

摘要： A topical therapeutic hydrophobic breakable composition includes a carrier comprising (a) about 60% to about 99% by weight of at least one hydrophobic oil; (b) at least one viscosity-modifying agents selected from the group consisting of a fatty alcohol, a fatty acid and a wax; and (c) a tetracycline antibiotic, characterized in that at least part of the tetracycline antibiotic is suspended in the composition; the viscosity of the composition is at least about 30% higher than the viscosity of the carrier without the tetracycline antibiotic; and is higher than the viscosity of the hydrophobic oil and the tetracycline antibiotic without the viscosity modifying agents. The tetracycline is chemically stable in the composition for at least six months; wherein more than about 90% of the tetracycline has not broken down. The composition is packaged as a breakable foam that breaks easily upon application of shear force.

公开(公告)号：US20200022912A1

公开(公告)日：2020-01-23

申请号：US16425610

申请日：2019-05-29

申请人： Foamix Pharmaceuticals Ltd.

发明人： Dov Tamarkin ,  Enbal Ziv ,  Yohan Hazot ,  David Schuz

IPC分类号： A61K9/12 ,  A61K47/44 ,  A61K8/04 ,  A61Q19/00 ,  A61K47/10 ,  A61K31/573 ,  A61K8/34

摘要： A substantially surface active agent-free and substantially polymeric agent-free foamable composition which includes short-chain alcohol, water, fatty alcohol or fatty acid or a combination of fatty alcohol and fatty acid and propellant. A substantially surface active agent-free and substantially polymeric agent-free foamable composition which includes water, fatty alcohol or fatty acid and propellant. A method of treatment using a substantially surface active agent-free and substantially polymeric agent-free foamable composition.

公开(公告)号：US20190307778A1

公开(公告)日：2019-10-10

申请号：US16353911

申请日：2019-03-14

申请人： Foamix Pharmaceuticals Ltd.

发明人： Meir EINI ,  Mitchell SHIRVAN ,  Rita KEYNAN ,  Tal BERMAN ,  David SCHUZ ,  Yohan HAZOT

IPC分类号： A61K31/65 ,  A61K9/12 ,  A61K9/06 ,  A61K47/06 ,  A61K47/44 ,  A61K45/06 ,  A61K47/12 ,  A61K47/10 ,  A61K9/00 ,  A61P17/10 ,  A61K47/24

摘要： Methods of treatment and dosage regimes using a composition comprising a tetracycline antibiotic in treating or alleviating a disorder including EGFRI associated rash, EGFRI associated rash related symptoms, a tetracycline antibiotic responsive EGFRI associated rash related disorder, skin disorder caused by a bacteria, and a tetracycline antibiotic responsive sebaceous gland disease, P. EGFRI associated rash bacteria associated disorders and other superficial infections, including skin infections are provided.

公开(公告)号：US20190282501A1

公开(公告)日：2019-09-19

申请号：US16072046

申请日：2017-01-25

申请人： FOAMIX PHARMACEUTICALS LTD.

发明人： Yohan HAZOT ,  Julia Nomi Biso FEIMAN ,  Dov TAMARKIN ,  David SCHUZ ,  Sarah Marissa CALEY ,  Bhushan HARDAS

IPC分类号： A61K9/12 ,  A61P31/10 ,  A61K31/135 ,  A61K47/10 ,  A61K47/38 ,  A61K47/18 ,  A61K9/00

摘要： The present disclosure relates to topical, hydroalcoholic foam formulations of antifungal agents, including allylamines such as naftifine. In some embodiments, the topical foam formulations comprise a carrier and a liquefied or compressed gas propellant, wherein the carrier comprises about 2% to about 4% by weight of naftifine hydrochloride; about 15% to about 35% by weight of a C1-6 alkyl alcohol; about 15% to about 30% by weight of an alkylene glycol; about 1% to about 2% by weight of a polymer; about 0.5% to about 2.0% by weight of a long chain fatty alcohol; a pH adjuster; about 0.01% to about 0.3% by weight of a chelating agent; water; and optionally about 0.5% to about 1.5% by weight of a preservative; wherein the propellant is present in the formation at about 5% to about 15% by weight of the formulation. Such compositions are useful for treating fungal infections including tinea capitis.

公开(公告)号：US20190247310A9

公开(公告)日：2019-08-15

申请号：US15903275

申请日：2018-02-23

申请人： Foamix Pharmaceuticals Ltd.

发明人： Dov Tamarkin ,  Doron Friedman ,  Tal Berman ,  Enbal Ziv ,  David Schuz

IPC分类号： A61K9/12 ,  A61K8/04 ,  A01N25/16 ,  A61Q19/00 ,  A61K8/362 ,  A61K8/86 ,  A61K8/49 ,  A61K8/37 ,  A61K9/00

摘要： The present invention teaches a foamable pharmaceutical carrier comprising a benefit agent, selected from the group consisting of a dicarboxylic acid and a dicarboxylic acid ester; a stabilizer selected from the group consisting of at least one surface-active agent; at least one polymeric agent and mixtures thereof; a solvent selected from the group consisting of water, a hydrophilic solvent, a hydrophobic solvent, a potent solvent, a polar solvent, a silicone, an emollient, and mixtures thereof, wherein the benefit agent, stabilizer and solvent are selected to provide a composition that is substantially resistant to aging and to phase separation and or can substantially stabilize other active ingredients. The invention further relates to a foamable composition further containing a liquefied hydrocarbon gas propellant.

公开(公告)号：US10322085B2

公开(公告)日：2019-06-18

申请号：US16189767

申请日：2018-11-13

申请人： Foamix Pharmaceuticals Ltd.

发明人： Dov Tamarkin ,  Doron Friedman ,  Tal Berman ,  Enbal Ziv ,  David Schuz

IPC分类号： A61K9/12 ,  A61K8/362 ,  A61K8/37 ,  A61K8/49 ,  A61K8/86 ,  A61K9/00 ,  A61Q19/00 ,  A01N25/16 ,  A61K8/04

摘要： The present invention teaches a foamable pharmaceutical carrier comprising a benefit agent, selected from the group consisting of a dicarboxylic acid and a dicarboxylic acid ester; a stabilizer selected from the group consisting of at least one surface-active agent; at least one polymeric agent and mixtures thereof; a solvent selected from the group consisting of water, a hydrophilic solvent, a hydrophobic solvent, a potent solvent, a polar solvent, a silicone, an emollient, and mixtures thereof, wherein the benefit agent, stabilizer and solvent are selected to provide a composition that is substantially resistant to aging and to phase separation and or can substantially stabilize other active ingredients. The invention further relates to a foamable composition further containing a liquefied hydrocarbon gas propellant.

公开(公告)号：US20190091149A1

公开(公告)日：2019-03-28

申请号：US15999088

申请日：2018-08-17

申请人： Foamix Pharmaceuticals Ltd.

发明人： Dov Tamarkin ,  Helena Shifrin ,  Rita Keynan ,  Enbal Ziv ,  Tal Berman ,  David Schuz ,  Elana Gazal

IPC分类号： A61K9/12 ,  A61K45/06 ,  A61K31/59 ,  A61K31/522 ,  A61K31/355 ,  A61K47/34 ,  A61K31/7056 ,  A61K47/44 ,  A61K8/04 ,  A61K9/00 ,  A61K31/65 ,  A61K47/06 ,  A61K47/14 ,  A61K47/24 ,  A61K31/20

摘要： A waterless foamable pharmaceutical composition suitable for external administration is disclosed. The composition includes a foamable carrier least one liquefied or compressed gas propellant. The foamable carrier includes at least one liquid oil; at least one silicone and at least one least one stabilizing agent; wherein the stabilizing agent selected from the group consisting of about 0.01% to about 25% by weight of at least one surface-active agent alone or on combination with a foam adjuvant; and about 0% to about 5% by weight of at least one polymeric agent alone or on combination with a foam adjuvant; and mixtures thereof. Pharmaceutical compositions comprising active agents, methods for their preparation, propellants suitable for use with the carriers and uses thereof are further described.

公开(公告)号：US10238746B2

公开(公告)日：2019-03-26

申请号：US14850655

申请日：2015-09-10

申请人： Foamix Pharmaceuticals Ltd.

发明人： Dov Tamarkin ,  Elana Gazal ,  Irakliy Papiashvili ,  Yohan Hazot ,  David Schuz ,  Rita Keynan

IPC分类号： A61K47/44 ,  A61K8/31 ,  A61K47/06 ,  A61K9/12 ,  A61K47/02 ,  A61K47/10 ,  A61K8/36 ,  A61K47/12 ,  A61K8/34 ,  A61K9/00 ,  A61Q19/00 ,  A61K31/65 ,  A61K31/4164 ,  A61K31/57 ,  A61K31/573 ,  A61K31/593 ,  A61K31/137 ,  A61K31/192 ,  A61K45/06 ,  A61K47/24 ,  A61Q17/04 ,  A61Q19/10

摘要： A substantially surface active agent tree composition which includes a hydrophobic solvent, and/or a petrolatm, a paraffin wax and/or a fatty alcohol, a fatty acid and/or a wax and/or shea butter, with and without a propellant. A substantially surface active agent free composition, further comprising, a tetracycline antibiotic, or a vitamin D derivative, or one or more other active agents. A method of treatment using a substantially surface active agent tree composition.