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1.发明授权Polymers containing multivalent amyloid-beta-binding D-peptides and their use 有权含多价淀粉样蛋白-β结合D-肽的聚合物及其用途公开(公告)号：US09464118B2
公开(公告)日：2016-10-11
申请号：US14388869
申请日：2013-04-05
发明人： Dieter Willbold , Susanne Aileen Funke , Oleksander Brener , Luitgard Nagel-Steger , Dirk Bartnik
CPC分类号： C07K14/4711 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/001 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
摘要： The invention relates to novel multivalent polymeric amyloid-beta-binding substances composed of several interconnected substances which per se already have amyloid-beta-binding properties, and to the use of these substances, referred to hereinbelow as “polymers”, in particular in medicine.
摘要翻译： 本发明涉及由本身已经具有淀粉样蛋白-β结合性质的几种相互连接的物质组成的新型多价聚合淀粉样蛋白-β结合物质，以及这些物质（以下称为“聚合物”），特别是在医学中的用途 。
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2.发明申请POLYMERS CONTAINING MULTIVALENT AMYLOID-BETA-BINDING D-PEPTIDES AND THEIR USE 有权含多元羧甲基-β-结合型D肽的聚合物及其用途公开(公告)号：US20150119336A1
公开(公告)日：2015-04-30
申请号：US14388869
申请日：2013-04-05
发明人： Dieter Willbold , Susanne Aileen Funke , Oleksander Brener , Luitgard Nagel-Steger , Dirk Bartnik
CPC分类号： C07K14/4711 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/001 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
摘要： The invention relates to novel multivalent polymeric amyloid-beta-binding substances composed of several interconnected substances which per se already have amyloid-beta-binding properties, and to the use of these substances, referred to hereinbelow as “polymers”, in particular in medicine.
摘要翻译： 本发明涉及由本身已经具有淀粉样蛋白-β结合性质的几种相互连接的物质组成的新型多价聚合淀粉样蛋白-β结合物质，以及这些物质（以下称为“聚合物”），特别是在医学中的用途 。
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公开(公告)号：US20190085030A1
公开(公告)日：2019-03-21
申请号：US16200820
申请日：2018-11-27
发明人： Dieter Willbold , Susanne Aileen Funke , Oleksander Brener , Luitgard Nagel-Steger , Dirk Bartnik , Antonia Nicole Klein
摘要： The present invention relates to novel D-enantiomeric A-beta-oligomer-binding peptides, homologs, fragments, parts and polymers thereof and use thereof.
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公开(公告)号：US10030056B2
公开(公告)日：2018-07-24
申请号：US14787130
申请日：2014-04-17
IPC分类号： C07K14/47 , A61K38/10 , A61K38/12 , A61K38/16 , A61K9/20 , A61K9/06 , A61K9/00 , C07K7/08 , A61K38/00
摘要： An agent for preventing and/or treating HIV and other viral infections. The agent in particular comprises at least one peptide, including an amino acid sequence, which is suitable for preventing fibrils associated with Alzheimer's disease, and/or homologs, fractions and parts thereof, so as to treat and/or prevent HIV and/or other viral infections.
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公开(公告)号：US11175288B2
公开(公告)日：2021-11-16
申请号：US14900361
申请日：2014-06-25
发明人： Dieter Willbold , Susanne Aileen Funke , Eva Birkmann , Kateryna Kravchenko , Oliver Bannach , Carsten Korth , Verian Bader , Steffen Huebinger
IPC分类号： G01N33/68 , C07K14/47 , G01N33/543 , G01N21/64 , G01N33/564
摘要： The invention concerns a method for detecting indicators for determining diseases (disease indicators), in which aggregates of misfolded proteins play a role, and a method for selective quantitation and/or characterization of these disease indicators.
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公开(公告)号：US10239923B2
公开(公告)日：2019-03-26
申请号：US15559078
申请日：2016-03-01
摘要： Peptides specifically binding amyloid beta and to methods of treating and diagnosing Alzheimer's dementia using such peptides are provided.
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7.发明授权Peptides for the treatment and early diagnosis of Alzheimer's disease and other tauopathies 有权用于治疗和早期诊断阿尔茨海默病和其他tau蛋白病的肽公开(公告)号：US09580469B2
公开(公告)日：2017-02-28
申请号：US14432802
申请日：2013-09-10
CPC分类号： C07K7/08 , A61K38/00 , C07K7/06 , C07K14/4711 , G01N33/6896 , G01N2800/2821
摘要： The present invention relates to novel tau protein aggregate-binding peptides, homologs, fragments, parts and polymers thereof and to the use thereof.
摘要翻译： 本发明涉及新型tau蛋白聚集体结合肽，其同系物，片段，部分和聚合物及其用途。
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8.发明申请公开(公告)号：US20180072786A1
公开(公告)日：2018-03-15
申请号：US15559078
申请日：2016-03-01
CPC分类号： C07K14/4711 , A61K38/00 , A61K38/10 , C07K7/08 , C07K7/64 , C07K14/4713 , G01N2333/4709 , G01N2800/2821
摘要： Peptides specifically binding amyloid beta and to methods of treating and diagnosing Alzheimer's dementia using such peptides are provided.
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公开(公告)号：US09611296B2
公开(公告)日：2017-04-04
申请号：US14439895
申请日：2013-09-25
发明人： Dieter Willbold , Susanne Aileen Funke , Yeliz Cinar , Dirk Bartnik , Hans-Ulrich Demuth , Martin Kleinschmidt , Hans-Henning Ludwig
CPC分类号： C07K7/08 , G01N33/6896 , G01N2333/4709
摘要： Peptides that bind to amino-terminal truncated pEAβ3-42, the free glutamic acid residue of which lies in position 3 or 11 in the form of cyclized pyroglutamate. Four oligopeptides were identified using mirror image phage display technology.
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公开(公告)号：US20150024512A1
公开(公告)日：2015-01-22
申请号：US14366952
申请日：2012-12-21
IPC分类号： G01N33/552 , G01N33/543
CPC分类号： G01N33/552 , C07K16/18 , G01N33/54393 , G01N33/6896 , G01N2333/4709 , G01N2458/00 , G01N2500/02 , G01N2800/2821
摘要： The invention relates to methods for selectively quantifying A-beta aggregates, comprising the immobilization of anti-A-beta antibodies on a substrate, application of the sample to be tested onto the substrate, addition of probes labeled for detection, which mark these by specific binding to A-beta aggregates and detection of the marked aggregates.
摘要翻译： 本发明涉及用于选择性定量A-β聚集体的方法，其包括将抗-A-β抗体固定在底物上，将待测试样品施用于底物上，加入标记为检测的探针， 结合A-β聚集体和检测标记的聚集体。
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