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1.发明授权Pharmaceutical compositions containing N-acetyl-cysteine derivatives useful for the treatment of cataract 失效含有用于治疗白内障的N-乙酰半胱氨酸衍生物的药物组合物
公开(公告)号：US5519054A
公开(公告)日：1996-05-21
申请号：US971577
申请日：1992-11-05
申请人： Francesco Santangelo , Giorgio Bertolini , Franco Pellacini , Luciano Soldati , Annibale Gazzaniga , Cesare Casagrande
发明人： Francesco Santangelo , Giorgio Bertolini , Franco Pellacini , Luciano Soldati , Annibale Gazzaniga , Cesare Casagrande
IPC分类号： A61K9/00 , A61K31/22 , A61K31/223 , A61K31/265 , A61P27/02 , A61P27/12 , C07C323/26 , A61K31/215
CPC分类号： A61K31/265 , A61K31/22 , A61K9/0048 , Y10S514/912
摘要： Pharmaceutical compositions for the treatment of cataract containing N-acetyl-L-cysteine derivatives of formula ##STR1## (wherein R and R.sub.1 have the meanings reported in the specification) are described.
摘要翻译： 描述了治疗含有式（I）的N-乙酰基-L-半胱氨酸衍生物（其中R和R 1具有说明书中报道的含义）的白内障的药物组合物。
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2.发明授权Beazimidazole compounds active as inhibitors of the cholesterol biosynthesis 失效活性为胆固醇生物合成抑制剂的比唑咪唑化合物
公开(公告)号：US4940800A
公开(公告)日：1990-07-10
申请号：US385369
申请日：1989-07-27
IPC分类号： C07D235/06 , A61K31/415 , A61K31/4184 , A61P3/06 , C07D235/18 , C07D235/24 , C07D405/06 , C07F7/18
CPC分类号： C07F7/1852 , C07D405/06
摘要： The compounds of formula ##STR1## wherein R, R.sub.1, R.sub.2, R.sub.3, and R.sub.4 have the meanings given in the specification, are described.The compounds of formula I are active as inhibitors of the enzyme HMG-CoA reductase and can be used in therapy as anti-hypercholesterolemics.
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3.发明授权2-amino-1,2,3,4-tetrahydronaphthalene derivatives active on the cardiovasular system, processes for their preparation and pharmaceutical compositions containing them 失效在心血管系统上活性的2-氨基-1,2,3,4-四氢萘衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：US5451608A
公开(公告)日：1995-09-19
申请号：US281698
申请日：1994-07-28
申请人： Francesco Santangelo , Giorgio Bertolini , Cesare Casagrande , Francesco Marchini , Stefania Montanari , Claudio Semeraro
发明人： Francesco Santangelo , Giorgio Bertolini , Cesare Casagrande , Francesco Marchini , Stefania Montanari , Claudio Semeraro
IPC分类号： A61K31/135 , A61K31/165 , A61K31/215 , A61K31/66 , A61K31/675 , A61P9/00 , A61P9/10 , A61P9/12 , A61P13/02 , A61P15/00 , A61P43/00 , C07C217/14 , C07C217/20 , C07C217/54 , C07C219/26 , C07C237/22 , C07C271/20 , C07C271/44 , C07D213/79 , C07F9/08 , C07F9/09
CPC分类号： C07C219/26 , C07C217/20 , C07C271/20 , C07C271/44 , C07C2102/10
摘要： Derivatives of 2-amino-1,2,3,4-tetrahydronaphthalene and their use in therapeutic field are described.The compounds are particularly useful in the treatment of arterial hypertension, cardiac decompensation and renal failure, in the treatment of peripheral arteriopathies and in cerebrovascular insufficiency.
摘要翻译： 描述了2-氨基-1,2,3,4-四氢萘的衍生物及其在治疗领域中的应用。 该化合物特别可用于治疗动脉高血压，心脏代偿失调和肾衰竭，用于治疗外周动脉病和脑血管功能不全。
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公开(公告)号：US5426179A
公开(公告)日：1995-06-20
申请号：US834769
申请日：1992-02-12
申请人： Giorgio Bertolini , Cesare Casagrande , Stefania Montanari , Gabriele Norcini , Francesco Santangelo
发明人： Giorgio Bertolini , Cesare Casagrande , Stefania Montanari , Gabriele Norcini , Francesco Santangelo
IPC分类号： A61K31/56 , A61K31/58 , A61P9/00 , A61P9/12 , C07J21/00 , C07J53/00 , C07J19/00 , A61K31/705
CPC分类号： C07J53/001 , C07J21/003
摘要： Steroid compounds active on the cardiovascular system of formula ##STR1## wherein X, n, R, R.sub.1 and R.sub.2 have the meanings mentioned in the description are described.
摘要翻译： 描述了其中X，n，R，R 1和R 2具有本说明书中提及的含义的式（I）的心血管系统上活性的类固醇化合物。
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5.发明授权2-amino-1,2,3,4-tetrahydronaphthalene derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing them 失效在心血管系统上活性的2-氨基-1,2,3,4-四氢萘衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：US5407956A
公开(公告)日：1995-04-18
申请号：US32845
申请日：1993-03-17
申请人： Francesco Santangelo , Giorgio Bertolini , Cesare Casagrande , Francesco Marchini , Stefania Montanari , Claudio Semeraro
发明人： Francesco Santangelo , Giorgio Bertolini , Cesare Casagrande , Francesco Marchini , Stefania Montanari , Claudio Semeraro
IPC分类号： A61K31/135 , A61K31/165 , A61K31/215 , A61K31/66 , A61K31/675 , A61P9/00 , A61P9/10 , A61P9/12 , A61P13/02 , A61P15/00 , A61P43/00 , C07C217/14 , C07C217/20 , C07C217/54 , C07C219/26 , C07C237/22 , C07C271/20 , C07C271/44 , C07D213/79 , C07F9/08 , C07F9/09
CPC分类号： C07C219/26 , C07C217/20 , C07C271/20 , C07C271/44 , C07C2102/10
摘要： Derivatives of 2-amino-1,2,3,4-tetrahydronaphthalene and their use in therapeutic field are described.The compounds are particularly useful in the treatment of arterial hypertension, cardiac decompensation and renal failure, in the treatment of peripheral arteriopathies and in cerebrovascular insufficiency.
摘要翻译： 描述了2-氨基-1,2,3,4-四氢萘的衍生物及其在治疗领域中的应用。 该化合物特别可用于治疗动脉高血压，心脏代偿失调和肾衰竭，用于治疗外周动脉病变和脑血管功能不全。
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公开(公告)号：US5221770A
公开(公告)日：1993-06-22
申请号：US950484
申请日：1992-09-25
IPC分类号： C07C213/02 , C07C217/74
CPC分类号： C07C217/74
摘要： A process is disclosed for the preparation of 2-amino-5,6-dimethoxy-tetralin, which is a useful intermediate for the preparation of pharmacologically active chemical compounds.
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公开(公告)号：US5196440A
公开(公告)日：1993-03-23
申请号：US519444
申请日：1990-05-04
IPC分类号： C07D405/06 , C07F7/18
CPC分类号： C07D405/06 , C07F7/1852
摘要： The compounds of formula ##STR1## wherein R, R.sub.1, R.sub.2, R.sub.3, and R.sub.4 have the meanings given in the specification, as described.The compounds of formula I are active as inhibitors of the enzyme HMG-CoA reductase and can be used in therapy as anti-hypercholesterolemics.
摘要翻译： 其中R，R 1，R 2，R 3和R 4具有如所述的说明书中给出的含义的式“IMAGE”的化合物。 式I化合物作为HMG-CoA还原酶的抑制剂是有活性的，可用作抗高胆固醇血症药物。
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8.发明授权17-aryl-substituted steroidal compounds active on the cardiovascular system 失效在心血管系统上活性的17-芳基取代的甾族化合物
公开(公告)号：US5424304A
公开(公告)日：1995-06-13
申请号：US4410
申请日：1993-01-15
CPC分类号： C07J9/00 , C07J17/005 , C07J31/006
摘要： Cardioactive steroidal compounds of the formula I ##STR1## wherein R, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6 and R.sub.7 have the meanings shown in the description, and pharmaceutical compositions containing them.
摘要翻译： 式I和R7的心脏活性甾体化合物具有说明书中所示的含义，以及含有它们的药物组合物。
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9.发明授权Diphosphates of catecholamines and pharmaceutical compositions containing them 失效儿茶酚胺的二磷酸盐和含有它们的药物组合物
公开(公告)号：US5438047A
公开(公告)日：1995-08-01
申请号：US204394
申请日：1994-03-28
CPC分类号： C07F9/12
摘要： Diphosphates of catecholamines having formula (I) wherein R, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and X have the meanings reported in the description, are useful in the therapy of cardiovascular and renal diseases. ##STR1##
摘要翻译： 式（I）的儿茶酚胺的二磷酸盐其中R，R 1，R 2，R 3，R 4，R 5，R 6，R 7和X具有说明书中报道的含义，可用于治疗心血管和肾脏疾病。 （一）
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公开(公告)号：US5151414A
公开(公告)日：1992-09-29
申请号：US738608
申请日：1991-07-31
IPC分类号： A61K31/135 , A61K31/215 , A61K31/265 , A61K31/27 , A61K31/33 , A61K31/66 , A61P9/00 , A61P9/08 , A61P9/12 , A61P25/28 , C07C217/14 , C07C217/20 , C07C219/26 , C07C219/28 , C07C271/44 , C07D521/00 , C07F9/12
CPC分类号： C07C271/44 , C07C217/20 , C07F9/12 , C07C2102/10
摘要： Compounds of formula ##STR1## (wherein R, R.sub.1, R.sub.2, R.sub.3, n, m and p have the meanings reported in the specification), their preparation and the compositions for pharmaceutical use containing them as active ingredient are described.The compounds of formula I have dopaminergic vasodilator activity and they may be used in pharmaceutical field.
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