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公开(公告)号：US06454787B1
公开(公告)日：2002-09-24
申请号：US09209600
申请日：1998-12-11
IPC分类号： A61B1708
CPC分类号： A61L15/325 , A61L15/425 , A61L2400/04 , C08L89/06 , Y10S128/08 , Y10S514/801
摘要： A hemostatic device formed of collagen particles and methods for producing and using the hemostatic device to control bleeding are provided. The collagen particles of the hemostatic device have a hemostatic activity that is equivalent to the hemostatic activity of the collagen particles from which the hemostatic device is formed. More preferably, the hemostatic devices are formed of Avitene® flour and the collagen particles of the hemostatic devices of the invention have a hemostatic activity equivalent to the hemostatic activity of Avitene® flour. The hemostatic devices optionally include hemostatic agents and/or therapeutic agents, to further promote hemostasis and wound healing.
摘要翻译： 提供由胶原颗粒形成的止血装置以及用于制造和使用止血装置以控制出血的方法。 止血装置的胶原颗粒具有等同于形成止血装置的胶原颗粒的止血活性的止血活性。 更优选地，止血装置由面粉形成，并且本发明的止血装置的胶原颗粒具有与Avitene面粉的止血活性相当的止血活性。 止血装置任选地包括止血剂和/或治疗剂，以进一步促进止血和伤口愈合。
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公开(公告)号：US06361551B1
公开(公告)日：2002-03-26
申请号：US09209723
申请日：1998-12-11
IPC分类号： A61B1708
CPC分类号： A61L15/325 , A61L2400/04 , D01D5/06 , D01F4/00
摘要： A collagen fiber and methods for producing and using the collagen fiber of the inventions to prepare hemostatic fabrics to control bleeding are provided. The collagen particles (e.g., fibrils) of the fiber, preferably, have a hemostatic activity that is equivalent to the hemostatic activity of the collagen particles from which the fiber is formed. The collagen fibers of the invention and hemostatic fabrics formed thereof optionally include hemostatic agents and/or other therapeutic agents, to further promote hemostasis and wound healing.
摘要翻译： 本发明提供了一种胶原纤维及其制备和使用本发明的胶原纤维以制备止血织物以控制出血的方法。 纤维的胶原颗粒（例如纤维）优选具有与形成纤维的胶原颗粒的止血活性相当的止血活性。 本发明的胶原纤维和由其形成的止血织物任选地包括止血剂和/或其它治疗剂，以进一步促进止血和伤口愈合。
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公开(公告)号：US07879108B2
公开(公告)日：2011-02-01
申请号：US10933080
申请日：2004-09-02
IPC分类号： A61F2/02
CPC分类号： A61F2/0063 , A61F2/0077
摘要： An implantable prosthesis is provided for repairing or augmenting anatomical weaknesses or defects, and is particularly suitable for the repair of soft tissue and muscle wall openings. The prosthesis may include a repair fabric that is constructed and arranged to allow tissue ingrowth and is susceptible to erosion into and the formation of adhesions with tissue and organs. One or more regions of the prosthesis may be configured to inhibit erosion into and/or the formation of adhesions with tissue and organs. The prosthesis may include an erosion resistant edge to buffer an edge of the fabric from the adjacent tissue or organs. The erosion resistant edge may be provided along an opening that is adapted to receive a tube-like structure, such as the esophagus.
摘要翻译： 为可修复或增加解剖缺陷或缺陷提供可植入假体，并且特别适用于修复软组织和肌肉壁开口。 假体可以包括构造和布置成允许组织向内生长并且易于侵蚀和与组织和器官形成粘连的修复织物。 假体的一个或多个区域可以被配置为抑制对组织和器官的粘连的侵蚀和/或形成粘连。 假体可以包括抗侵蚀边缘以从邻近的组织或器官缓冲织物的边缘。 抗侵蚀边缘可以沿着适于接收管状结构（例如食道）的开口设置。
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公开(公告)号：US07824420B2
公开(公告)日：2010-11-02
申请号：US10853823
申请日：2004-05-26
申请人： Stephen N. Eldridge , Roger Darois
发明人： Stephen N. Eldridge , Roger Darois
CPC分类号： A61F2/0063
摘要： An implantable prosthesis for an anatomical defect, such as a tissue or muscle defect, that promotes tissue or muscle growth into the prosthesis and subsequently strengthens the area of the defect. At least one pocket and preferably two concentric pockets may be provided to aid with manipulating the prosthesis. Where two pockets are used, a barrier or partition exists between the pockets and the outer pocket allows manipulation of the outer periphery. The incidence of postoperative adhesions between a portion of the prosthesis and tissue, muscle or organs may be minimized with the use of a barrier layer. Reinforcing members may be attached to portions of the prosthesis to aid in positioning and deployment in the area of desired coverage without rendering the prosthesis unduly difficult to implant or uncomfortable for the patient. Typically, two concentric members are employed. Further, the prosthesis is constructed to allow it to be provisionally held in place at desired locations by openings in the pockets that allow access for a stapler or sewing device.
摘要翻译： 用于解剖缺损的可植入假体，例如组织或肌肉缺损，其促进组织或肌肉生长进入假体并随后加强缺损区域。 可以提供至少一个口袋并且优选地两个同心的口袋来帮助操作假体。 在使用两个口袋的情况下，在凹穴之间存在隔离物或分隔件，并且外口袋允许操纵外周边。 可以使用阻挡层将假体和组织，肌肉或器官的一部分之间的术后粘连的发生率最小化。 加强构件可以附接到假体的部分，以帮助定位和展开在期望的覆盖区域，而不会使假体过度难以植入或不适合患者。 通常使用两个同心的构件。 此外，假体构造成允许其通过允许缝合器或缝合装置进入的口袋中的开口临时保持在所需位置。
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公开(公告)号：US06736823B2
公开(公告)日：2004-05-18
申请号：US10143564
申请日：2002-05-10
IPC分类号： A61F202
CPC分类号： A61F2/0063 , A61B17/00234 , A61B17/12013
摘要： An implantable prosthesis is provided for repairing or augmenting anatomical weaknesses or defects, and is particularly suitable for the repair of soft tissue and muscle wall openings. The prosthesis is configured to promote enhanced tissue ingrowth thereto, while limiting the incidence of post-operative adhesions between the fabric and tissue or organs. The prosthesis may include a layer of fabric that is constructed and arranged to allow tissue ingrowth and is susceptible to the formation of adhesions for tissue and organs. One or more barriers may be provided on selected portions of the fabric to inhibit the formation of adhesions with tissues and organs. The prosthesis may have an opening that is adapted to receive the esophagus or other tube-like structure, or other projection, that passes through an opening in or projects from a tissue, muscle or organ wall requiring repair and/or augmentation. The prosthesis may be configured for use in hiatal hernia repair and/or treatment of GERD. A method is also provided for the treatment of GERD.
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公开(公告)号：US06270530B1
公开(公告)日：2001-08-07
申请号：US09591516
申请日：2000-06-09
IPC分类号： A61F236
CPC分类号： D04B21/12 , A61F2/0063 , A61F2002/0068 , A61F2210/0076 , D10B2403/0112 , D10B2403/0213 , D10B2509/08 , Y10S623/902 , Y10S623/926
摘要： A prosthetic repair fabric including a sheet of tissue infiltratable fabric and a second sheet, also preferably including tissue infiltratable fabric, which is united with the first sheet. The second sheet is fused to an adhesion resistant barrier, forming a laminate composite prosthesis without degrading the mechanical properties or tissue ingrowith capability of the first sheet.
摘要翻译： 一种假体修复织物，其包括组织可渗透织物片和第二片，还优选包括与第一片合并的组织渗透性织物。 将第二片材熔合到耐粘附屏障上，形成层压复合假体，而不会降低第一片材的机械性能或组织内翻性能。
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公开(公告)号：US06790213B2
公开(公告)日：2004-09-14
申请号：US10040936
申请日：2002-01-07
申请人： Dennis Cherok , Stephen N. Eldridge , Roger E. Darois , Patrick J. Devlin , Matthew R. Fenton , Steven Palmer Ford , Philip A. Tessier
发明人： Dennis Cherok , Stephen N. Eldridge , Roger E. Darois , Patrick J. Devlin , Matthew R. Fenton , Steven Palmer Ford , Philip A. Tessier
IPC分类号： A61B1708
CPC分类号： A61F2/0063
摘要： An implantable prosthesis for an anatomical defect, such as a tissue or muscle defect, that promotes tissue or muscle growth into the prosthesis and subsequently strengthens the area of the defect. At least one pocket and preferably two concentric pockets may be provided to aid with manipulating the prosthesis. Where two pockets are used, a barrier or partition exists between the pockets and the outer pocket allows manipulation of the outer periphery. The incidence of postoperative adhesions between a portion of the prosthesis and tissue, muscle or organs may be minimized with the use of a barrier layer. Reinforcing members may be attached to portions of the prosthesis to aid in positioning and deployment in the area of desired coverage without rendering the prosthesis unduly difficult to implant or uncomfortable for the patient. Typically, two concentric members are employed. Further, the prosthesis is constructed to allow it to be provisionally held in place at desired locations by openings in the pockets that allow access for a stapler or sewing device.
摘要翻译： 用于解剖缺损的可植入假体，例如组织或肌肉缺损，其促进组织或肌肉生长进入假体并随后加强缺损区域。 可以提供至少一个口袋并且优选地两个同心的口袋来帮助操作假体。 在使用两个口袋的情况下，在凹穴之间存在隔离物或分隔件，并且外口袋允许操纵外周边。 可以使用阻挡层将假体和组织，肌肉或器官的一部分之间的术后粘连的发生率最小化。 加强构件可以附接到假体的部分，以帮助定位和展开在期望的覆盖区域，而不会使假体过度难以植入或不适合患者。 通常使用两个同心的构件。 此外，假体构造成允许其通过允许缝合器或缝合装置进入的口袋中的开口临时保持在所需位置。
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公开(公告)号：US6120539A
公开(公告)日：2000-09-19
申请号：US850217
申请日：1997-05-01
CPC分类号： D04B21/12 , A61F2/0063 , A61F2002/0068 , A61F2210/0076 , D10B2403/0112 , D10B2403/0213 , D10B2509/08 , Y10S623/902 , Y10S623/926
摘要： A prosthetic repair fabric including a sheet of tissue infiltratable fabric and a second sheet, also preferably including tissue infiltratable fabric, which is united with the first sheet. The second sheet is fused to an adhesion resistant barrier, forming a laminate composite prosthesis without degrading the mechanical properties or tissue ingrowth capability of the first sheet.
摘要翻译： 一种假体修复织物，其包括组织可渗透织物片和第二片，还优选包括与第一片合并的组织渗透性织物。 将第二片材熔合到耐粘附屏障上，形成层压复合假体，而不降低第一片材的机械性能或组织向内生长能力。
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公开(公告)号：US5716408A
公开(公告)日：1998-02-10
申请号：US656554
申请日：1996-05-31
CPC分类号： A61F2/0063 , A61B17/0057 , A61F2002/30205 , A61F2230/0067
摘要： An implantable prosthesis for repairing or reconstructing a tissue or muscle wall defect including an outer plug and at least two inner filler plugs positioned within the outer plug that stiffen, and impart bulk to, the outer plug when the implant is inserted into the narrow confines of the tissue or muscle wall defect.
摘要翻译： 一种用于修复或重建组织或肌肉壁缺损的可植入假体，其包括外部塞子和位于外部塞子内的至少两个内部填充塞子，当将植入物插入到狭窄的狭窄区域 组织或肌肉壁缺损。
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10.发明申请公开(公告)号：US20130296897A1
公开(公告)日：2013-11-07
申请号：US13460938
申请日：2012-05-01
申请人： Anthony Trupiano , Stephen N. Eldridge , Donald Anthony Coelho, JR. , Kevin J. Ranucci , Roger E. Darois
发明人： Anthony Trupiano , Stephen N. Eldridge , Donald Anthony Coelho, JR. , Kevin J. Ranucci , Roger E. Darois
IPC分类号： A61B17/03
CPC分类号： A61F2/0063 , A61F2/0077 , A61F2002/0068 , A61F2230/0091
摘要： The present invention is an implantable adhesive mesh prosthesis for reinforcing and/or repairing a defect in tissue that is easy to roll into a small diameter cylinder or other low-profile shape for passing through a trocar, incision, or other surgical instrument. More specifically, the adhesive may be applied to the mesh material in a pattern that leaves a significant portion of the surface area of the mesh material free of adhesive. In one embodiment, the adhesive is applied only near the outer perimeter of the mesh product. In another embodiment, the adhesive is applied in spots over all or a portion the surface of the mesh product. In yet another embodiment, the adhesive is applied in parallel lines on the surface of the mesh product and the mesh may be rolled up around an axis parallel to the lines of adhesive.
摘要翻译： 本发明是一种用于加强和/或修复组织中的缺陷的可植入粘合剂网络假体，该缺损易于卷入小直径的圆柱体或其它小轮廓形状以穿过套管针，切口或其它手术器械。 更具体地，粘合剂可以以离开网状材料的表面积的大部分没有粘合剂的图案施加到网状材料。 在一个实施例中，粘合剂仅施加在网状产品的外周附近。 在另一个实施方案中，将粘合剂施加在网状产品的全部或部分表面上的斑点上。 在另一个实施方案中，粘合剂以网格产品的表面上的平行线施加，并且网可以围绕平行于粘合剂线的轴卷起。
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