公开(公告)号：US08660651B2

公开(公告)日：2014-02-25

申请号：US12164875

申请日：2008-06-30

申请人： J. Chris Castel ,  Francis X. Palermo

发明人： J. Chris Castel ,  Francis X. Palermo

IPC分类号： A61N1/18

CPC分类号： A61N1/36003 ,  A61K31/00 ,  A61K31/047 ,  A61K31/135 ,  A61K31/138 ,  A61K31/167 ,  A61K31/195 ,  A61K31/197 ,  A61K31/202 ,  A61K31/357 ,  A61K31/381 ,  A61K31/385 ,  A61K31/407 ,  A61K31/4164 ,  A61K31/4415 ,  A61K31/485 ,  A61K31/506 ,  A61K31/55 ,  A61K31/714 ,  A61K38/185 ,  A61N1/36021

摘要： An electrical stimulation method for the treatment of peripheral neuropathy is disclosed. In a preferred embodiment, the method utilizes an electrical stimulation device that includes a plurality of channels of electrodes each of which includes a first and second electrode positioned in electrical contact with tissue of a target region suffering from peripheral neuropathy. Agonist/antagonist muscles involved in abduction/adduction, flexion/extension, supination/pronation, protraction/retraction, and/or eversion/inversion in the peripheral body regions are stimulated with a patterned series of electrical pulses through channels of electrodes in accordance with a procedure for treating peripheral neuropathy. The patterned series of electrical pulses may comprise: a plurality of cycles of a biphasic sequential pulse train pattern; a plurality of cycles of a biphasic overlapping pulse train pattern; a plurality of cycles of a triphasic sequential pulse train pattern; and a plurality of cycles of a triphasic overlapping pulse train pattern.

摘要翻译： 公开了一种治疗周围神经病变的电刺激方法。 在优选实施例中，该方法使用电刺激装置，其包括多个电极通道，每个通道包括与周围神经病变的靶区域的组织电接触的第一和第二电极。 参与外展/内收，屈曲/伸展，仰卧/旋转，伸出/缩回和/或外周体区域中的/反转/反转的激动剂/拮抗剂肌肉通过根据电极的通道的电极的图案化系列的电脉冲被刺激 治疗周围神经病的手术。 图案化的一系列电脉冲可以包括：多个循环的双相顺序脉冲串模式; 双相重叠脉冲序列的多个周期; 三相序列脉冲串模式的多个周期; 以及三相重叠脉冲串模式的多个周期。

公开(公告)号：US20150290457A1

公开(公告)日：2015-10-15

申请号：US14252273

申请日：2014-04-14

申请人： Francis X. Palermo ,  J. Chris Castel

发明人： Francis X. Palermo ,  J. Chris Castel

IPC分类号： A61N1/32 ,  A61N1/20 ,  A61N1/36

CPC分类号： A61N1/323 ,  A61N1/0452 ,  A61N1/0456 ,  A61N1/0476 ,  A61N1/0492 ,  A61N1/0526 ,  A61N1/0531 ,  A61N1/0548 ,  A61N1/20 ,  A61N1/36003 ,  A61N1/36025 ,  A61N1/36146

摘要： An electrical stimulation system and method for the treatment of neurological disorders is disclosed. In a preferred embodiment, the electrical stimulation system includes channels of electrodes positioned in electrical contact with tissue of a neuromuscular target body region of a patient to provide pattered neuromuscular stimulation to the patient's musculature. In addition, at least one electrode from a channel is positioned in electrical contact with a tissue of the motor control region of the brain. A series of patterned electrical pulses are then applied to the patient through the channels to provide peripheral neuromuscular stimulation, and a direct current is applied transcranially to the brain. Various exemplary embodiments of the invention are disclosed.

摘要翻译： 公开了一种用于治疗神经障碍的电刺激系统和方法。 在优选实施例中，电刺激系统包括定位成与患者的神经肌肉靶体区域的组织电接触的电极通道，以向患者的肌肉组织提供图案化的神经肌肉刺激。 此外，来自通道的至少一个电极定位成与脑的马达控制区域的组织电接触。 然后通过通道将一系列图案化的电脉冲施加到患者以提供周围神经肌肉刺激，并且将直流电经常地施加到脑上。 公开了本发明的各种示例性实施例。

公开(公告)号：US20160243354A9

公开(公告)日：2016-08-25

申请号：US14252273

申请日：2014-04-14

申请人： Francis X. Palermo ,  J. Chris Castel

发明人： Francis X. Palermo ,  J. Chris Castel

IPC分类号： A61N1/32 ,  A61N1/20 ,  A61N1/36

CPC分类号： A61N1/323 ,  A61N1/0452 ,  A61N1/0456 ,  A61N1/0476 ,  A61N1/0492 ,  A61N1/0526 ,  A61N1/0531 ,  A61N1/0548 ,  A61N1/20 ,  A61N1/36003 ,  A61N1/36025 ,  A61N1/36146

摘要： An electrical stimulation system and method for the treatment of neurological disorders is disclosed. In a preferred embodiment, the electrical stimulation system includes channels of electrodes positioned in electrical contact with tissue of a neuromuscular target body region of a patient to provide pattered neuromuscular stimulation to the patient's musculature. In addition, at least one electrode from a channel is positioned in electrical contact with a tissue of the motor control region of the brain. A series of patterned electrical pulses are then applied to the patient through the channels to provide peripheral neuromuscular stimulation, and a direct current is applied transcranially to the brain. Various exemplary embodiments of the invention are disclosed.

公开(公告)号：US08738142B2

公开(公告)日：2014-05-27

申请号：US13113389

申请日：2011-05-23

申请人： Francis X. Palermo ,  J. Chris Castel

发明人： Francis X. Palermo ,  J. Chris Castel

IPC分类号： A61N1/18

CPC分类号： A61N1/323 ,  A61N1/0452 ,  A61N1/0456 ,  A61N1/0476 ,  A61N1/0492 ,  A61N1/0526 ,  A61N1/0531 ,  A61N1/0548 ,  A61N1/20 ,  A61N1/36003 ,  A61N1/36025 ,  A61N1/36146

摘要： An electrical stimulation system and method for the treatment of neurological disorders is disclosed. In a preferred embodiment, the electrical stimulation system includes channels of electrodes positioned in electrical contact with tissue of a neuromuscular target body region of a patient to provide pattered neuromuscular stimulation to the patient's musculature. In addition, at least one electrode from a channel is positioned in electrical contact with a tissue of the motor control region of the brain. A series of patterned electrical pulses are then applied to the patient through the channels to provide peripheral neuromuscular stimulation, and a direct current is applied transcranially to the brain. Various exemplary embodiments of the invention are disclosed.

摘要翻译： 公开了一种用于治疗神经障碍的电刺激系统和方法。 在优选实施例中，电刺激系统包括定位成与患者的神经肌肉靶体区域的组织电接触的电极通道，以向患者的肌肉组织提供图案化的神经肌肉刺激。 此外，来自通道的至少一个电极定位成与脑的马达控制区域的组织电接触。 然后通过通道将一系列图案化的电脉冲施加到患者以提供周围神经肌肉刺激，并且将直流电经常地施加到脑上。 公开了本发明的各种示例性实施例。

公开(公告)号：US20090326607A1

公开(公告)日：2009-12-31

申请号：US12164875

申请日：2008-06-30

申请人： J. Chris Castel ,  Francis X. Palermo

发明人： J. Chris Castel ,  Francis X. Palermo

IPC分类号： A61N1/04 ,  A61K39/395 ,  A61K35/60 ,  A61K31/202 ,  A61K31/385 ,  A61K31/047 ,  A61K38/18 ,  A61K31/4415 ,  A61K31/407 ,  A61K31/506 ,  A61K31/714 ,  A61K31/485 ,  A61K31/195 ,  A61K31/357 ,  A61K31/197 ,  A61K31/55 ,  A61K31/4164 ,  A61K31/167 ,  A61K31/135 ,  A61K31/381 ,  A61K31/138

CPC分类号： A61N1/36003 ,  A61K31/00 ,  A61K31/047 ,  A61K31/135 ,  A61K31/138 ,  A61K31/167 ,  A61K31/195 ,  A61K31/197 ,  A61K31/202 ,  A61K31/357 ,  A61K31/381 ,  A61K31/385 ,  A61K31/407 ,  A61K31/4164 ,  A61K31/4415 ,  A61K31/485 ,  A61K31/506 ,  A61K31/55 ,  A61K31/714 ,  A61K38/185 ,  A61N1/36021

摘要： An electrical stimulation method for the treatment of peripheral neuropathy is disclosed. In a preferred embodiment, the method utilizes an electrical stimulation device that includes a plurality of channels of electrodes each of which includes a first and second electrode positioned in electrical contact with tissue of a target region suffering from peripheral neuropathy. Agonist/antagonist muscles involved in abduction/adduction, flexion/extension, supination/pronation, protraction/retraction, and/or eversion/inversion in the peripheral body regions are stimulated with a patterned series of electrical pulses through channels of electrodes in accordance with a procedure for treating peripheral neuropathy. The patterned series of electrical pulses may comprise: a plurality of cycles of a biphasic sequential pulse train pattern; a plurality of cycles of a biphasic overlapping pulse train pattern; a plurality of cycles of a triphasic sequential pulse train pattern; and a plurality of cycles of a triphasic overlapping pulse train pattern.

摘要翻译： 公开了一种治疗周围神经病变的电刺激方法。 在优选实施例中，该方法使用电刺激装置，其包括多个电极通道，每个通道包括与周围神经病变的靶区域的组织电接触的第一和第二电极。 参与外展/内收，屈曲/伸展，仰卧/旋转，伸出/缩回和/或外周体区域中的/反转/反转的激动剂/拮抗剂肌肉通过根据电极的通道的电极的图案化系列的电脉冲被刺激 治疗周围神经病的手术。 图案化的一系列电脉冲可以包括：多个循环的双相顺序脉冲串模式; 双相重叠脉冲序列的多个周期; 三相序列脉冲串模式的多个周期; 以及三相重叠脉冲串模式的多个周期。

公开(公告)号：US20080208287A1

公开(公告)日：2008-08-28

申请号：US11711285

申请日：2007-02-27

申请人： Francis X. Palermo ,  J. Chris Castel

发明人： Francis X. Palermo ,  J. Chris Castel

IPC分类号： A61N1/00

CPC分类号： A61N1/323 ,  A61N1/0452 ,  A61N1/0456 ,  A61N1/0476 ,  A61N1/0492 ,  A61N1/0526 ,  A61N1/0531 ,  A61N1/0548 ,  A61N1/20 ,  A61N1/36003 ,  A61N1/36025 ,  A61N1/36146

摘要： An electrical stimulation system and method for the treatment of neurological disorders is disclosed. In a preferred embodiment, the electrical stimulation system includes channels of electrodes positioned in electrical contact with tissue of a neuromuscular target body region of a patient to provide pattered neuromuscular stimulation to the patient's musculature. In addition, at least one electrode from a channel is positioned in electrical contact with a tissue of the motor control region of the brain. A series of patterned electrical pulses are then applied to the patient through the channels to provide peripheral neuromuscular stimulation, and a direct current is applied transcranially to the brain. Various exemplary embodiments of the invention are disclosed.

摘要翻译： 公开了一种用于治疗神经障碍的电刺激系统和方法。 在优选实施例中，电刺激系统包括定位成与患者的神经肌肉靶体区域的组织电接触的电极通道，以向患者的肌肉组织提供图案化的神经肌肉刺激。 此外，来自通道的至少一个电极定位成与脑的马达控制区域的组织电接触。 然后通过通道将一系列图案化的电脉冲施加到患者以提供周围神经肌肉刺激，并且将直流电经常地施加到脑上。 公开了本发明的各种示例性实施例。

公开(公告)号：US09802039B2

公开(公告)日：2017-10-31

申请号：US14252273

申请日：2014-04-14

申请人： Francis X. Palermo ,  J. Chris Castel

发明人： Francis X. Palermo ,  J. Chris Castel

IPC分类号： A61N1/32 ,  A61N1/04 ,  A61N1/05 ,  A61N1/36 ,  A61N1/20

CPC分类号： A61N1/323 ,  A61N1/0452 ,  A61N1/0456 ,  A61N1/0476 ,  A61N1/0492 ,  A61N1/0526 ,  A61N1/0531 ,  A61N1/0548 ,  A61N1/20 ,  A61N1/36003 ,  A61N1/36025 ,  A61N1/36146

摘要： An electrical stimulation system and method for the treatment of neurological disorders is disclosed. In a preferred embodiment, the electrical stimulation system includes channels of electrodes positioned in electrical contact with tissue of a neuromuscular target body region of a patient to provide pattered neuromuscular stimulation to the patient's musculature. In addition, at least one electrode from a channel is positioned in electrical contact with a tissue of the motor control region of the brain. A series of patterned electrical pulses are then applied to the patient through the channels to provide peripheral neuromuscular stimulation, and a direct current is applied transcranially to the brain. Various exemplary embodiments of the invention are disclosed.

公开(公告)号：US20110224753A1

公开(公告)日：2011-09-15

申请号：US13113389

申请日：2011-05-23

申请人： Francis X. Palermo ,  J. Chris Castel

发明人： Francis X. Palermo ,  J. Chris Castel

IPC分类号： A61N1/36

CPC分类号： A61N1/323 ,  A61N1/0452 ,  A61N1/0456 ,  A61N1/0476 ,  A61N1/0492 ,  A61N1/0526 ,  A61N1/0531 ,  A61N1/0548 ,  A61N1/20 ,  A61N1/36003 ,  A61N1/36025 ,  A61N1/36146

摘要： An electrical stimulation system and method for the treatment of neurological disorders is disclosed. In a preferred embodiment, the electrical stimulation system includes channels of electrodes positioned in electrical contact with tissue of a neuromuscular target body region of a patient to provide pattered neuromuscular stimulation to the patient's musculature. In addition, at least one electrode from a channel is positioned in electrical contact with a tissue of the motor control region of the brain. A series of patterned electrical pulses are then applied to the patient through the channels to provide peripheral neuromuscular stimulation, and a direct current is applied transcranially to the brain. Various exemplary embodiments of the invention are disclosed.

摘要翻译： 公开了一种用于治疗神经障碍的电刺激系统和方法。 在优选实施例中，电刺激系统包括定位成与患者的神经肌肉靶体区域的组织电接触的电极通道，以向患者的肌肉组织提供图案化的神经肌肉刺激。 此外，来自通道的至少一个电极定位成与脑的马达控制区域的组织电接触。 然后通过通道将一系列图案化的电脉冲施加到患者以提供周围神经肌肉刺激，并且将直流电经常地施加到脑上。 公开了本发明的各种示例性实施例。

公开(公告)号：US07949403B2

公开(公告)日：2011-05-24

申请号：US11711285

申请日：2007-02-27

申请人： Francis X. Palermo ,  J. Chris Castel

发明人： Francis X. Palermo ,  J. Chris Castel

IPC分类号： A61N1/00

CPC分类号： A61N1/323 ,  A61N1/0452 ,  A61N1/0456 ,  A61N1/0476 ,  A61N1/0492 ,  A61N1/0526 ,  A61N1/0531 ,  A61N1/0548 ,  A61N1/20 ,  A61N1/36003 ,  A61N1/36025 ,  A61N1/36146

摘要： An electrical stimulation system and method for the treatment of neurological disorders is disclosed. In a preferred embodiment, the electrical stimulation system includes channels of electrodes positioned in electrical contact with tissue of a neuromuscular target body region of a patient to provide pattered neuromuscular stimulation to the patient's musculature. In addition, at least one electrode from a channel is positioned in electrical contact with a tissue of the motor control region of the brain. A series of patterned electrical pulses are then applied to the patient through the channels to provide peripheral neuromuscular stimulation, and a direct current is applied transcranially to the brain. Various exemplary embodiments of the invention are disclosed.

摘要翻译： 公开了一种用于治疗神经障碍的电刺激系统和方法。 在优选实施例中，电刺激系统包括定位成与患者的神经肌肉靶体区域的组织电接触的电极通道，以向患者的肌肉组织提供图案化的神经肌肉刺激。 此外，来自通道的至少一个电极定位成与脑的马达控制区域的组织电接触。 然后通过通道将一系列图案化的电脉冲施加到患者以提供周围神经肌肉刺激，并且将直流电经常地施加到脑上。 公开了本发明的各种示例性实施例。

公开(公告)号：US07660636B2

公开(公告)日：2010-02-09

申请号：US11325196

申请日：2006-01-04

申请人： J. Chris Castel ,  Francis X. Palermo

发明人： J. Chris Castel ,  Francis X. Palermo

IPC分类号： A61N1/18

CPC分类号： A61N1/36014 ,  A61N1/0456 ,  A61N1/36007 ,  A61N1/3601

摘要： An electrical stimulation device and method for the treatment of dysphagia is disclosed. In a preferred embodiment, the electrical stimulation device includes one or more channels of electrodes each of which includes a first electrode positioned in electrical contact with tissue of a target region of a patient and a second electrode positioned in electrical contact with tissue of a posterior neck region or a posterior thoracic region of the patient. A series of electrical pulses are then applied to the patient through the one or more channels of electrodes in accordance with a procedure for treating dysphagia. The series of electrical pulses may comprise: a plurality of cycles of a biphasic sequential pulse train pattern; a plurality of cycles of a biphasic overlapping pulse train pattern; a plurality of cycles of a triphasic sequential pulse train pattern; a plurality of cycles of a triphasic overlapping pulse train pattern; a functional pulse train pattern; a low-frequency pulse train pattern; or a frequency-sequenced pulse burst train pattern. Various exemplary embodiments of the invention are disclosed.

摘要翻译： 公开了一种用于治疗吞咽困难的电刺激装置和方法。 在优选实施例中，电刺激装置包括一个或多个电极通道，每个通道包括定位成与患者的目标区域的组织电接触的第一电极和定位成与后颈部的组织电接触的第二电极 区域或后胸部区域。 然后根据用于治疗吞咽困难的程序，通过一个或多个电极通道将一系列电脉冲施加给患者。 一系列电脉冲可以包括：多个循环的双相顺序脉冲串模式; 双相重叠脉冲序列的多个周期; 三相序列脉冲串模式的多个周期; 三相重叠脉冲序列的多个周期; 功能脉冲串模式; 低频脉冲串模式; 或频率序列脉冲串列表模式。 公开了本发明的各种示例性实施例。