-
1.发明授权Method of testing inert, displaceable diluents used in forming shaped hydrogel articles 失效用于形成成形水凝胶制品的惰性可置换稀释剂的测试方法
公开(公告)号：US5736409A
公开(公告)日：1998-04-07
申请号：US645999
申请日：1996-05-14
IPC分类号： C08J5/00 , B29D11/02 , C08F2/00 , C08F2/44 , C08F2/48 , C08L71/02 , G02B1/04 , G01N25/20 , B29D11/00
CPC分类号： G02B1/043 , C08F2/00 , Y10S524/916
摘要： Method of testing inert displaceable diluents used in forming shaped hydrogel articles such as soft contact lenses prepared by the steps of: (1) molding or casting a polymerization mixture including: (a) a monomer mixture having a major proportion of one or more hydrophilic monomers such as 2-hydroxyethyl methacrylate, and one or more cross-linking monomers; and (b) an inert, displaceable diluent chosen from: (i) ethoxylated alkyl glucoside; (ii) ethoxylated bisphenol A; (iii) polyethylene glycol; (iv) mixture of propoxylated and ethoxylated alkyl glucoside; (v) single phase mixture of ethoxylated or propoxylated alkyl gtucoside and C.sub.2-12 dihydric alcohol; (vi) adduct of .epsilon.-caprolactone and C.sub.2-6 alkanediols and triols;(vii) ethoxylated C.sub.3-6 alkanetriol; and (viii) mixtures of one or more of (i) through (vii), under conditions to polymerize the monomer mixture to produce a shaped gel of a copolymer of the monomers and the diluent; and (2) thereafter replacing the diluent with water.
摘要翻译： 测试用于形成成形水凝胶制品（例如由以下步骤制备的软性隐形眼镜）的惰性可置换稀释剂的方法：（1）模制或浇铸聚合混合物，其包括：（a）主要比例的一种或多种亲水单体的单体混合物 如甲基丙烯酸2-羟乙酯和一种或多种交联单体; 和（b）惰性的可置换的稀释剂，其选自：（i）乙氧基化烷基葡糖苷; （ii）乙氧基化双酚A; （iii）聚乙二醇; （iv）丙氧基化和乙氧基化烷基葡糖苷的混合物; （v）乙氧基化或丙氧基化烷基葡糖苷和C2-12二元醇的单相混合物; （vi）ε-己内酯和C 2-6烷二醇和三醇的加合物; （vii）乙氧基化C3-6烷醇三醇; 和（viii）（i）至（vii）中的一种或多种的混合物，在使单体混合物聚合以产生单体和稀释剂的共聚物的成形凝胶的条件下; 和（2）此后用水代替稀释剂。
-
公开(公告)号：US5648402A
公开(公告)日：1997-07-15
申请号：US457832
申请日：1995-06-01
IPC分类号： G02C7/04 , A61F2/16 , A61F9/00 , A61L27/00 , C08F299/00 , C08G18/50 , C08G77/42 , G02B1/04 , C08G18/61 , C07H15/08 , C08G18/64
摘要： The present invention provides soft contact lenses adopted for placement over the cornea or in the eye which have a high oxygen permeability, a low water content and excellent mechanical properties. Moreover, the lenses of the instant invention have excellent protein and lipid deposition resistance relative to conventional contact lenses. Such lenses having the properties mentioned above comprises a prepolymer which contains an alkoxylate glucoside that is derivatized with at least one polysiloxane compound. The prepolymer is then placed in a suitable mold and polymerized by exposure to ultraviolet light.
摘要翻译： 本发明提供了用于放置在角膜或眼睛中的具有高透氧性，低含水量和优异的机械性能的软性隐形眼镜。 此外，本发明的镜片相对于常规隐形眼镜具有优异的蛋白质和脂质沉积阻力。 具有上述性质的这种透镜包含预聚物，其包含用至少一种聚硅氧烷化合物衍生化的烷氧基化物葡糖苷。 然后将预聚物置于合适的模具中，并通过暴露于紫外线进行聚合。
-
公开(公告)号：US5490960A
公开(公告)日：1996-02-13
申请号：US456133
申请日：1995-05-31
IPC分类号： C08J5/00 , B29D11/02 , C08F2/00 , C08F2/44 , C08F2/48 , C08L71/02 , G02B1/04 , B29D11/00 , C08L33/14
CPC分类号： G02B1/043 , C08F2/00 , Y10S524/916
摘要： Shaped hydrogel articles such as soft contact lenses are prepared by the steps of:(1) molding or casting a polymerization mixture comprising:(a) a monomer mixture comprising a major proportion of one or more hydrophilic monomers such as 2-hydroxyethyl methacrylate, and one or more cross-linking monomers; and(b) an inert, displaceable diluent selected from the group consisting of:(i) ethoxylated alkyl glucoside;(ii) ethoxylated bisphenol A;(iii) polyethylene glycol;(iv) mixture of propoxylated and ethoxylated alkyl glucoside;(v) single phase mixture of ethoxylated or propoxylated alkyl glucoside and C.sub.2-12 dihydric alcohol;(vi) adduct of .epsilon.-caprolactone and C.sub.2-6 alkanediols and triols;(vii) ethoxylated C.sub.3-6 alkanetriol; and(viii) mixtures of one or more of (i) through (vii),under conditions to polymerize said monomer mixture to produce a shaped gel of a copolymer of said monomers and said diluent; and(2) thereafter replacing said diluent with water.
-
公开(公告)号：US5684058A
公开(公告)日：1997-11-04
申请号：US410025
申请日：1995-03-24
IPC分类号： C08J5/00 , B29D11/02 , C08F2/00 , C08F2/44 , C08F2/48 , C08L71/02 , G02B1/04 , C08F24/00 , G02C7/04
CPC分类号： G02B1/043 , C08F2/00 , Y10S524/916
摘要： Shaped hydrogel articles such as soft contact lenses are prepared by the steps of: (1) molding or casting a polymerization mixture comprising: (a) a monomer mixture comprising a major proportion of one or more hydrophilic monomers such as 2-hydroxyethyl methacrylate, and one or more cross-linking monomers; and (b) an inert, displaceable diluent selected from the group consisting of: (i) ethoxylated alkyl glucoside; (ii) ethoxylated bisphenol A; (iii) polyethylene glycol; (iv) mixture of propoxylated and ethoxylated alkyl glucoside; (v) single phase mixture of ethoxylated or propoxylated alkyl glucoside and C.sub.2-12 dihydric alcohol; (vi) adduct of .epsilon.-caprolactone and C.sub.2-6 alkanediols and triols;(vii) ethoxylated C.sub.3-6 alkanetriol; and (viii) mixtures of one or more of (i) through (vii), under conditions to polymerize said monomer mixture to produce a shaped gel of a copolymer of said monomers and said diluent; and (2) thereafter replacing said diluent with water.
-
公开(公告)号：US5498379A
公开(公告)日：1996-03-12
申请号：US455357
申请日：1995-05-31
IPC分类号： C08J5/00 , B29D11/02 , C08F2/00 , C08F2/44 , C08F2/48 , C08L71/02 , G02B1/04 , B29D11/00 , C08J7/02 , C08K5/12 , C08L101/14
CPC分类号： G02B1/043 , C08F2/00 , Y10S524/916
摘要： Shaped hydrogel articles such as soft contact lenses are prepared by the steps of:(1) molding or casting a polymerization mixture comprising:(a) a monomer mixture comprising a major proportion of one or more hydrophilic monomers such as 2-hydroxyethyl methacrylate, and one or more cross-linking monomers; and(b) an inert, displaceable diluent selected from the group consisting of:(i) ethoxylated alkyl glucoside;(ii) ethoxylated bisphenol A;(iii) polyethylene glycol;(iv) mixture of propoxylated and ethoxylated alkyl glucoside;(v) single phase mixture of ethoxylated or propoxylated alkyl glucoside and C.sub.2-12 dihydric alcohol;(vi) adduct of .epsilon.-caprolactone and C.sub.2-6 alkanediols and triols;(vii) ethoxylated C.sub.3-6 alkanetriol; and(viii) mixtures of one or more of (i) through (vii),under conditions to polymerize said monomer mixture to produce a shaped gel of a copolymer of said monomers and said diluent; and(2) thereafter replacing said diluent with water.
-
公开(公告)号：US5681871A
公开(公告)日：1997-10-28
申请号：US449004
申请日：1995-05-24
申请人： Frank F. Molock , Ivan M. Nunez , James D. Ford
发明人： Frank F. Molock , Ivan M. Nunez , James D. Ford
IPC分类号： G02C7/04 , B29D11/00 , B29K33/04 , C08F2/44 , C08F8/00 , C08F8/14 , C08J7/14 , G02B1/04 , G02C7/10 , C08L33/04 , C08K5/09
CPC分类号： C08F8/14 , C08J7/14 , G02B1/043 , C08F2810/20 , C08F2810/30
摘要： Disclosed is a process for producing an ultraviolet radiation absorbing contact lens from a lens shaped polymer having hydroxyl groups pendant therefrom and having dispersed therein a UV absorbing agent substituted with at least one anhydride group which is exposed to basic conditions such that the hydroxyl groups react with the anhydride groups on the UV absorbing agent. As a result the UV absorbing agent becomes fixed to the polymer through the formation of a covalent ester bond.
摘要翻译： 本发明公开了一种从具有从其侧基具有羟基的透镜形聚合物制备紫外线吸收隐形眼镜的方法，其中分散有由至少一个酸酐基取代的紫外线吸收剂，所述酸酐基暴露于碱性条件使得羟基与 UV吸收剂上的酸酐基团。 结果，UV吸收剂通过形成共价酯键而固定在聚合物上。
-
7.发明授权Polymeric ophthalmic lens prepared from unsaturated polyoxyethylene monomers 失效由不饱和聚氧乙烯单体制备的聚合物眼科镜片
公开(公告)号：US5484863A
公开(公告)日：1996-01-16
申请号：US156135
申请日：1993-11-22
申请人： Frank F. Molock , Ivan M. Nunez , James D. Ford
发明人： Frank F. Molock , Ivan M. Nunez , James D. Ford
IPC分类号： C08F290/06 , G02B1/04 , C08F226/02 , C08F236/20 , G02C7/04
CPC分类号： C08F290/062 , G02B1/043 , Y10S525/937
摘要： A soft hydrogel contact lens, is disclosed. The lens is derived from a crosslinked polymer comprising the reaction product of a monomer mixture comprising:(A) a monounsaturated polyoxyethylene monomer;(B) a diunsaturated polyoxyethylene monomer of relatively high molecular weight;(C) a diunsaturated polyoxyethylene monomer of relatively low molecular weight; and(D) a hydrophilic monomer selected from the group consisting of hydroxyethyl methacrylate, methacrylic acid, N,N-dimethylacryiamide, N-vinyl pyrrolidone, glycerol monomethacrylate, itaconic acid, and mixtures thereof.
摘要翻译： 公开了一种柔软的水凝胶隐形眼镜。 透镜衍生自包含单体混合物的反应产物的交联聚合物，所述单体混合物包含：（A）单不饱和聚氧乙烯单体; （B）相对较高分子量的二不饱和聚氧乙烯单体; （C）相对低分子量的二不饱和聚氧乙烯单体; 和（D）选自甲基丙烯酸羟乙酯，甲基丙烯酸，N，N-二甲基丙烯酰胺，N-乙烯基吡咯烷酮，单甲基丙烯酸甘油酯，衣康酸及其混合物的亲水性单体。
-
公开(公告)号：US5490959A
公开(公告)日：1996-02-13
申请号：US455948
申请日：1995-05-31
IPC分类号： C08J5/00 , B29D11/02 , C08F2/00 , C08F2/44 , C08F2/48 , C08L71/02 , G02B1/04 , B29D11/00 , C08L33/14
CPC分类号： G02B1/043 , C08F2/00 , Y10S524/916
摘要： Shaped hydrogel articles such as soft contact lenses are prepared by the steps of:(1) molding or casting a polymerization mixture comprising:(a) a monomer mixture comprising a major proportion of one or more hydrophilic monomers such as 2-hydroxyethyl methacrylate, and one or more cross-linking monomers; and(b) an inert, displaceable diluent selected from the group consisting of:(i) ethoxylated alkyl glucoside;(ii) ethoxylated bisphenol A;(iii) polyethylene glycol;(iv) mixture of propoxylated and ethoxylated alkyl glucoside;(v) single phase mixture of ethoxylated or propoxylated alkyl glucoside and C.sub.2-12 dihydric alcohol;(vi) adduct of .epsilon.-caprolactone and C.sub.2-6 alkanediols and triols;(vii) ethoxylated C.sub.3-6 alkanetriol; and(viii) mixtures of one or more of (i) through (vii),under conditions to polymerize said monomer mixture to produce a shaped gel of a copolymer of said monomers and said diluent; and(2) thereafter replacing said diluent with water.
-
9.发明授权Method of forming shaped hydrogel articles including contact lenses using inert, displaceable diluents 失效形成水凝胶制品的方法，包括使用惰性可置换稀释剂的隐形眼镜
公开(公告)号：US5910519A
公开(公告)日：1999-06-08
申请号：US918714
申请日：1997-08-01
CPC分类号： G02B1/043 , Y10S524/916
摘要： Shaped hydrogel articles such as soft contact lenses are prepared by the steps of:(1) molding or casting a polymerization mixture comprising:(a) a monomer mixture comprising a major proportion of one or more hydrophilic monomers such as 2-hydroxyethyl methacrylate, and one or more cross-linking monomers; and(b) an inert, displaceable diluent selected from the group consisting of:(i) ethoxylated alkyl glucoside;(ii) ethoxylated bisphenol A;(iii) polyethylene glycol;(iv) mixture of propoxylated and ethoxylated alkyl glucoside;(v) single phase mixture of ethoxylated or propoxylated alkyl glucoside and C.sub.2-12 dihydric alcohol;(vi) adduct of .epsilon.-caprolactone and C.sub.2-6 alkanediols and triols;(vii) ethoxylated C.sub.3-6 alkanetriol; and(viii) mixtures of one or more of (i) through (vii),under conditions to polymerize said monomer mixture to produce a shaped gel of a copolymer of said monomers and said diluent; and(2) thereafter replacing said diluent with water.
摘要翻译： 形成的水凝胶制品如软性隐形眼镜是通过以下步骤制备的：（1）模制或浇铸聚合混合物，其包含：（a）包含主要比例的一种或多种亲水性单体如甲基丙烯酸2-羟乙酯和 一种或多种交联单体; 和（b）惰性的可置换的稀释剂，其选自：（i）乙氧基化烷基葡糖苷; （ii）乙氧基化双酚A; （iii）聚乙二醇; （iv）丙氧基化和乙氧基化烷基葡糖苷的混合物; （v）乙氧基化或丙氧基化烷基葡糖苷和C2-12二元醇的单相混合物; （vi）ε-己内酯和C 2-6烷二醇和三醇的加合物; （vii）乙氧基化C3-6烷醇三醇; 和（viii）（i）至（vii）中的一种或多种的混合物，在使所述单体混合物聚合以产生所述单体和所述稀释剂的共聚物的成型凝胶的条件下; 和（2）此后用水代替所述稀释剂。
-
10.发明授权
公开(公告)号：US5690953A
公开(公告)日：1997-11-25
申请号：US712657
申请日：1996-09-13
IPC分类号： A61F9/00 , A61L27/00 , C08F290/06 , C08F291/06 , C08G18/32 , C08G65/32 , C08G83/00 , C08L101/00 , G02B1/04 , C08B37/00
CPC分类号： G02B1/043 , C08F290/062
摘要： An ophthalmic lens, particularly a soft hydrogel contact lens, is disclosed. The lens can be derived from a crosslinked polymer made by reacting a hydrophilic monomer with a crosslinking amount of a polyfunctional compound containing a saccharide residue. The preferred hydrophilic monomer is actually a mixture of the following individual hydrophilic monomers: a) the reaction product of a free radical reactive monoisocyanate and a monoalkoxy polyalkylether, b) N,N-dimethylacrylamide, and optionally c)hydroxyethyl methacrylate. The preferred polyfunctional compound is a prepolymer derived from an alkoxylated glucose or sucrose. This prepolymer can be made by reacting glucose or sucrose, which has been ethoxylated or propoxylated, with a free radical reactive isocyanate which has been capped. The free radical reactive isocyanate can be capped by reacting it with a polyalkylether, such as polyethylene glycol, and then reacting this intermediate with a diisocyanate.
摘要翻译： 公开了一种眼用透镜，特别是软水凝胶隐形眼镜。 透镜可以衍生自通过使亲水性单体与交联量的含有糖残基的多官能化合物反应制备的交联聚合物。 优选的亲水性单体实际上是以下各个亲水单体的混合物：a）自由基反应性单异氰酸酯和单烷氧基聚烷基醚的反应产物，b）N，N-二甲基丙烯酰胺和任选的c）甲基丙烯酸羟乙酯。 优选的多官能化合物是衍生自烷氧基化葡萄糖或蔗糖的预聚物。 该预聚物可以通过已经被乙氧基化或丙氧基化的葡萄糖或蔗糖与被封端的自由基活性异氰酸酯反应来制备。 自由基反应性异氰酸酯可以通过与聚烷基醚如聚乙二醇反应来封端，然后使该中间体与二异氰酸酯反应。
-
-
-
-
-
-
-
-
-
搜索结果
47 条记录 (耗时 0.02 秒)
