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    Bicyclic heterocycles, drugs containing said compounds, use thereof, and method for production thereof
    1.
    发明授权
    Bicyclic heterocycles, drugs containing said compounds, use thereof, and method for production thereof 有权
    双环杂环，含有所述化合物的药物，其用途及其生产方法

    公开(公告)号：US07998949B2

    公开(公告)日：2011-08-16

    申请号：US12525742

    申请日：2008-01-30

    申请人： Frank Himmelsbach ,  Birgit Jung ,  Ralf Lotz ,  Markus Ostermeier

    发明人： Frank Himmelsbach ,  Birgit Jung ,  Ralf Lotz ,  Markus Ostermeier

    IPC分类号： A61K31/517

    CPC分类号： C07D239/94 ,  C07D401/12

    摘要： The present invention relates to bicyclic heterocycles of general formula wherein Ra, Rb and Rc are defined as in claim 1, their tautomers, their stereoisomers, their mixtures and their salts, in particular their physiologically acceptable salts with inorganic or organic acids and bases, which have valuable pharmacological properties, in particular an inhibitory action on the signal transduction mediated by tyrosine kinases, their use for the treatment of illnesses, in particular of tumoral diseases and of benign prostatic hyperplasia (BPH), of diseases of the lung and of the airways, and the preparation thereof.

    摘要翻译： 本发明涉及通式的双环杂环，其中Ra，Rb和Rc如权利要求1所定义，其互变异构体，其立体异构体，其混合物及其盐，特别是其与无机或有机酸和碱的生理上可接受的盐，其中 具有有价值的药理学特性，特别是对由酪氨酸激酶介导的信号转导的抑制作用，其用于治疗疾病，特别是肿瘤疾病和良性前列腺增生（BPH））肺和气道疾病的用途 ，及其制备。

    Spirocyclic heterocycles medicaments containing said compounds, use thereof and method for their production
    2.
    发明授权
    Spirocyclic heterocycles medicaments containing said compounds, use thereof and method for their production 有权
    含有所述化合物的螺环杂环药物，其用途及其制备方法

    公开(公告)号：US08772298B2

    公开(公告)日：2014-07-08

    申请号：US13920389

    申请日：2013-06-18

    申请人： Frank Himmelsbach ,  Birgit Jung ,  Ralf Lotz

    发明人： Frank Himmelsbach ,  Birgit Jung ,  Ralf Lotz

    IPC分类号： A61K31/497 ,  A61K31/517

    CPC分类号： C07D403/12

    摘要： The present invention relates to spirocyclic heterocycles of general formula (I) the tautomers, the stereoisomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids, which have valuable pharmacological properties, particularly an inhibitory effect on signal transduction mediated by tyrosine kinases, the use thereof for the treatment of diseases, particularly tumoral diseases as well as benign prostatic hyperplasia (BPH), diseases of the lungs and airways, and the preparation thereof.

    摘要翻译： 本发明涉及通式（I）的互变异构体，其立体异构体，其混合物及其盐，特别是其与无机或有机酸的生理上可接受的盐的螺环杂环，其具有有价值的药理学性质，特别是对 由酪氨酸激酶介导的信号转导，其用于治疗疾病，特别是肿瘤疾病以及良性前列腺增生（BPH），肺和气道疾病的用途及其制备。

    CYCLOHEXYLOXY SUBSTITUTED HETEROCYCLES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS AND PROCESSES FOR PREPARING THEM
    3.
    发明申请
    CYCLOHEXYLOXY SUBSTITUTED HETEROCYCLES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS AND PROCESSES FOR PREPARING THEM 有权
    CYCLOHEXYLOXY取代的杂环化合物，含有这些化合物的药物组合物及其制备方法

    公开(公告)号：US20110190248A1

    公开(公告)日：2011-08-04

    申请号：US13057872

    申请日：2009-07-23

    申请人： Frank Himmelsbach ,  Birgit Jung ,  Ralf Lotz

    发明人： Frank Himmelsbach ,  Birgit Jung ,  Ralf Lotz

    IPC分类号： A61K31/517 ,  A61K31/56 ,  C07D403/12 ,  A61P29/00 ,  A61P37/08 ,  A61P11/00 ,  A61P11/06 ,  A61P11/14 ,  A61P35/00

    CPC分类号： C07D403/12

    摘要： The present invention relates to cyclohexyloxy-substituted heterocycles of general formula (I) the tautomers, the stereoisomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids, which have valuable pharmacological properties, particularly an inhibitory effect on signal transduction mediated by tyrosine kinases, the use thereof for the treatment of diseases, particularly tumoral diseases as well as benign prostatic hyperplasia (BPH), diseases of the lungs and airways and the preparation thereof.

    摘要翻译： 本发明涉及通式（I）的环己氧基取代的杂环，互变异构体，立体异构体，其混合物及其盐，特别是其与无机或有机酸的生理上可接受的盐，其具有有价值的药理学性质，特别是抑制性 对酪氨酸激酶介导的信号转导的作用，其用于治疗疾病，特别是肿瘤疾病以及良性前列腺增生（BPH），肺和气道疾病及其制备的用途。

    Spirocyclic Heterocycles Medicaments Containing Said Compounds, Use Thereof And Method For Their Production
    4.
    发明申请
    Spirocyclic Heterocycles Medicaments Containing Said Compounds, Use Thereof And Method For Their Production 有权
    含有所述化合物的螺环杂环药物及其制备方法及其制备方法

    公开(公告)号：US20110046148A1

    公开(公告)日：2011-02-24

    申请号：US12865431

    申请日：2009-02-05

    申请人： Frank Himmelsbach ,  Birgit Jung ,  Ralf Lotz

    发明人： Frank Himmelsbach ,  Birgit Jung ,  Ralf Lotz

    IPC分类号： A61K31/499 ,  C07D403/12 ,  A61K31/517 ,  A61P37/08 ,  A61P29/00

    CPC分类号： C07D403/12

    摘要： The present invention relates to spirocyclic heterocycles of general formula (I) the tautomers, the stereoisomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids, which have valuable pharmacological properties, particularly an inhibitory effect on signal transduction mediated by tyrosine kinases, the use thereof for the treatment of diseases, particularly tumoral diseases as well as benign prostatic hyperplasia (BPH), diseases of the lungs and airways, and the preparation thereof.

    摘要翻译： 本发明涉及通式（I）的互变异构体，其立体异构体，其混合物及其盐，特别是其与无机或有机酸的生理上可接受的盐的螺环杂环，其具有有价值的药理学性质，特别是对 由酪氨酸激酶介导的信号转导，其用于治疗疾病，特别是肿瘤疾病以及良性前列腺增生（BPH），肺和气道疾病的用途及其制备。

    Cyclohexyloxy substituted heterocycles, pharmaceutical compositions containing these compounds and processes for preparing them
    5.
    发明授权
    Cyclohexyloxy substituted heterocycles, pharmaceutical compositions containing these compounds and processes for preparing them 有权
    环己氧基取代的杂环，含有这些化合物的药物组合物及其制备方法

    公开(公告)号：US08648191B2

    公开(公告)日：2014-02-11

    申请号：US13057872

    申请日：2009-07-23

    申请人： Frank Himmelsbach ,  Birgit Jung ,  Ralf Lotz

    发明人： Frank Himmelsbach ,  Birgit Jung ,  Ralf Lotz

    IPC分类号： C07D239/70

    CPC分类号： C07D403/12

    摘要： The present invention relates to cyclohexyloxy-substituted heterocycles of general formula (I) the tautomers, the stereoisomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids, which have valuable pharmacological properties, particularly an inhibitory effect on signal transduction mediated by tyrosine kinases, the use thereof for the treatment of diseases, particularly tumoral diseases as well as benign prostatic hyperplasia (BPH), diseases of the lungs and airways and the preparation thereof.

    摘要翻译： 本发明涉及通式（I）的环己氧基取代的杂环，互变异构体，立体异构体，其混合物及其盐，特别是其与无机或有机酸的生理上可接受的盐，其具有有价值的药理学性质，特别是抑制性 对酪氨酸激酶介导的信号转导的作用，其用于治疗疾病，特别是肿瘤疾病以及良性前列腺增生（BPH），肺和气道疾病及其制备的用途。

    Spirocyclic heterocycles medicaments containing said compounds, use thereof and method for their production
    6.
    发明授权
    Spirocyclic heterocycles medicaments containing said compounds, use thereof and method for their production 有权
    含有所述化合物的螺环杂环药物，其用途及其制备方法

    公开(公告)号：US08497369B2

    公开(公告)日：2013-07-30

    申请号：US12865431

    申请日：2009-02-05

    申请人： Frank Himmelsbach ,  Birgit Jung ,  Ralf Lotz

    发明人： Frank Himmelsbach ,  Birgit Jung ,  Ralf Lotz

    IPC分类号： C07D239/70 ,  C07D233/00 ,  C07D241/04

    CPC分类号： C07D403/12

    摘要： The present invention relates to spirocyclic heterocycles of general formula (I) the tautomers, the stereoisomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids, which have valuable pharmacological properties, particularly an inhibitory effect on signal transduction mediated by tyrosine kinases, the use thereof for the treatment of diseases, particularly tumoral diseases as well as benign prostatic hyperplasia (BPH), diseases of the lungs and airways, and the preparation thereof.

    摘要翻译： 本发明涉及通式（I）的互变异构体，其立体异构体，其混合物及其盐，特别是其与无机或有机酸的生理上可接受的盐的螺环杂环，其具有有价值的药理学性质，特别是对 由酪氨酸激酶介导的信号转导，其用于治疗疾病，特别是肿瘤疾病以及良性前列腺增生（BPH），肺和气道疾病的用途及其制备。

    Bicyclic heterocycles, medicaments containing said compounds, use thereof, and method for production of same
    10.
    发明授权
    Bicyclic heterocycles, medicaments containing said compounds, use thereof, and method for production of same 有权
    双环杂环，含有所述化合物的药物，其用途及其制备方法

    公开(公告)号：US08399461B2

    公开(公告)日：2013-03-19

    申请号：US12513731

    申请日：2007-11-03

    申请人： Frank Himmelsbach ,  Birgit Jung

    发明人： Frank Himmelsbach ,  Birgit Jung

    IPC分类号： A61K31/517 ,  A61K31/5377 ,  A61K31/497 ,  C07D239/94 ,  C07D413/12 ,  C07D403/12

    CPC分类号： C07D239/94

    摘要： The present invention relates to bicyclic heterocycles of general formula the tautomers, the stereoisomers, the mixtures and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids which have valuable pharmacological properties, particularly an inhibitory effect on signal transduction mediated by tyrosine kinases, the use thereof for treating diseases, particularly tumoral diseases, as well as benign prostatic hyperplasia (BPH), diseases of the lungs and respiratory tract, and the preparation thereof.

    摘要翻译： 本发明涉及通式为其互变异构体，立体异构体，混合物和盐的双环杂环，特别是其与具有有价值药理学性质的无机或有机酸的生理上可接受的盐，特别是对由酪氨酸介导的信号转导的抑制作用 激酶，其用于治疗疾病，特别是肿瘤疾病，以及良性前列腺增生（BPH），肺和呼吸道疾病的用途及其制备。