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27 条记录 (耗时 0.022 秒)

    Method of preparing quinolines, naphthyridines and other nitrogen bi-heterocyclic compounds
    3.
    发明授权
    Method of preparing quinolines, naphthyridines and other nitrogen bi-heterocyclic compounds 失效
    制备喹啉，萘啶和其他氮双杂环化合物的方法

    公开(公告)号：US4380632A

    公开(公告)日：1983-04-19

    申请号：US286432

    申请日：1981-07-24

    申请人： Klaus-Dieter Steffen

    发明人： Klaus-Dieter Steffen

    IPC分类号： C07D215/22 ,  C07D215/233 ,  C07D215/48 ,  C07D471/04 ,  C07D471/00 ,  C07D215/16 ,  C07D215/20 ,  C07D487/00

    CPC分类号： C07D215/233 ,  C07D471/04

    摘要： A method for the preparation of nitrogen bi-heterocyclic compounds is disclosed involving the saponification of a compound of the formula ##STR1## wherein R, E, D, B, A, and R' have the previously assigned significance which comprises saponifying the same by contacting it with at least a stoichiometric amount of water followed by decarboxylation.The carboxylic acid esters can be those formed by cyclization of dicarboxylic acid esters such as alpha-picolylaminomethylenemalonic acid diethyl ester.

    摘要翻译： 公开了一种制备氮双杂环化合物的方法，其涉及式（II）化合物的皂化，其中R，E，D，B，A和R'具有先前指定的含义，其包括皂化 通过使其与至少一种化学计量的水接触，然后脱羧来进行。 羧酸酯可以是通过二羧酸酯如α-吡啶甲基氨基亚甲基丙二酸二乙酯的环化形成的那些。

    3-Amino-4,5,6-trichloro-7-nitriloindazoles
    4.
    发明授权
    3-Amino-4,5,6-trichloro-7-nitriloindazoles 失效
    3-氨基-4,5,6-三氯-7-硝基吲唑

    公开(公告)号：US3963739A

    公开(公告)日：1976-06-15

    申请号：US601950

    申请日：1975-08-04

    申请人： Klaus-Dieter Steffen

    发明人： Klaus-Dieter Steffen

    IPC分类号： C07D231/56

    CPC分类号： C07D231/56

    摘要： A compound having the formula ##SPC1##Wherein R is hydrogen, a C.sub.1-6 alkyl, a C.sub.1-6 chloroalkyl, a phenyl or an alkyl-substituted phenyl radical, a process for preparing such compound by contacting tetrachlorisophthalic acid dinitrile with hydrazine or a hydrazine derivative of the formulaH.sub.2 N--NHRin which R has the previously ascribed significance.

    摘要翻译： 具有式WHEREIN R是氢，C 1-6烷基，C 1-6氯烷基，苯基或烷基取代的苯基的化合物，通过使四氯间苯二甲酸二腈与肼或肼衍生物接触来制备该化合物的方法 其中R具有先前所述的含义的式H2N-NHR。

    Process for preparing malonic acid and alkylmalonic acids
    5.
    发明授权
    Process for preparing malonic acid and alkylmalonic acids 失效
    制备丙二酸和烷基丙二酸的方法

    公开(公告)号：US5886219A

    公开(公告)日：1999-03-23

    申请号：US19792

    申请日：1998-02-06

    申请人： Klaus-Dieter Steffen

    发明人： Klaus-Dieter Steffen

    IPC分类号： C07C27/02 ,  C07C51/09 ,  C07C51/43 ,  C07C51/46 ,  C07C51/48 ,  C07C55/02 ,  C07C55/08 ,  C07C61/04

    CPC分类号： C07C51/09

    摘要： Malonic acid and alkylmalonic acids are prepared by a process of acid-catalyzed saponification of malonic acid esters, which comprises:contacting an aqueous mixture of the ester II with an acid ion exchanger containing sulfonic acid groups at from 30.degree.-100.degree. C. and from 40-1000 mbar according to the following scheme: ##STR1## where R.sup.1 =H, CH.sub.3,R.sup.2 =H, CH.sub.3 orR.sup.1 +R.sup.2 =--CH.sub.2 --CH.sub.2 --andR.sup.3 =CH.sub.3, C.sub.2 H.sub.5, C.sub.3 H.sub.7, C(CH.sub.3).sub.3 ;distilling off the alcohol R.sup.3 OH which is formed;separating the water, with the aid of organic solvents, from the malonic acid or alkylmalonic acid product; and thenisolating the product by crystallization.

    摘要翻译： 丙二酸和烷基丙二酸是通过酸催化皂化丙二酸酯的方法制备的，该方法包括：使酯II的含水混合物与含有磺酸基的酸离子交换剂在30℃-100℃下接触， 其中R1 = H，CH3，R2 = H，CH3或R1 + R2 = -CH2-CH2-和R3 = CH3，C2H5，C3H7，C（CH3）3 ; 蒸馏形成的醇R3OH; 在有机溶剂的帮助下，从丙二酸或烷基丙二酸产物中分离水; 然后通过结晶分离产物。

    Process for the preparation of cyclopropane-1, 1-dicarboxylic acid derivatives
    6.
    发明授权
    Process for the preparation of cyclopropane-1, 1-dicarboxylic acid derivatives 失效
    制备环丙烷-1,1-二羧酸衍生物的方法

    公开(公告)号：US5869737A

    公开(公告)日：1999-02-09

    申请号：US910895

    申请日：1997-08-13

    申请人： Klaus-Dieter Steffen

    发明人： Klaus-Dieter Steffen

    IPC分类号： C07C51/353 ,  C07C67/343 ,  C07C69/74

    CPC分类号： C07C51/353 ,  C07C67/343

    摘要： A cyclopropane-1,1-dicarboxylic acid compound is prepared by reacting a malonic acid compound and a 1,2-dihalogeno compound with an alcoholate as a condensation agent which is gradually added to a mixture of said malonic acid compound and said 1,2-chloro compound as a solution or suspension is an alcohol.

    摘要翻译： 通过使丙二酸化合物和1,2-二卤代化合物与作为缩合剂的醇化物反应制备环丙烷-1,1-二羧酸化合物，其逐渐加入到所述丙二酸化合物和所述1,2-二卤代化合物的混合物中 - 氯化合物作为溶液或悬浮液是醇。

    Process for preparing alkyl- and arylmalonic acids
    7.
    发明授权
    Process for preparing alkyl- and arylmalonic acids 失效
    制备烷基和芳基丙二酸的方法

    公开(公告)号：US5849949A

    公开(公告)日：1998-12-15

    申请号：US64005

    申请日：1998-04-21

    申请人： Klaus-Dieter Steffen

    发明人： Klaus-Dieter Steffen

    IPC分类号： C07C27/02 ,  C07C51/09 ,  C07C51/48 ,  C07C55/02 ,  C07C57/36 ,  C07C61/04 ,  C07C61/09 ,  C07C51/00

    CPC分类号： C07C51/09

    摘要： Alkyl- and arylmalonic acids of the formula I ##STR1## where R.sup.1 =H, C.sub.1 -C.sub.12 -alkyl, phenyl, C.sub.1 -C.sub.4 -alkylphenyl, C.sub.2 -C.sub.4 -dialkylphenyl, R.sup.2 =C.sub.1 -C.sub.12 -alkyl, phenyl, C.sub.1 -C.sub.4 -alkylphenyl, C.sub.2 -C.sub.4 -dialkylphenyl or R.sup.1 +R.sup.2 =--CH.sub.2 --CH.sub.2 --, are prepared by alkaline saponification by hydrolyzing the corresponding C.sub.1 -C.sub.4 -alkyl esters of the malonic acid of formula I, with alkali metal hydroxide dissolved in an aqueous alkali metal salt solution containing salt at 90-100% of saturation, acidifying the hydrolysis product with a mineral acid, removing the precipitated alkali metal salt which forms upon acidification, and extracting the alkyl- and arylmalonic acid formed from the aqueous solution with the aid of an organic solvent.

    摘要翻译： 式I的烷基和芳基丙二酸（I）其中R1 = H，C1-C12-烷基，苯基，C1-C4-烷基苯基，C2-C4-二烷基苯基，R2 = C1-C12-烷基，苯基， C 1 -C 4 - 烷基苯基，C 2 -C 4 - 二烷基苯基或R 1 + R 2 = -CH 2 -CH 2 - ，是通过碱溶解通过水解相应的式I的丙二酸的C 1 -C 4烷基酯与碱金属氢氧化物 在含有90-100％饱和盐的碱金属盐水溶液中，用无机酸酸化水解产物，除去在酸化时形成的沉淀的碱金属盐，并提取由水溶液形成的烷基和芳基丙二酸 借助有机溶剂。

    Process for preparing n-alkyllactams
    8.
    发明授权
    Process for preparing n-alkyllactams 失效
    制备正烷基内酰胺的方法

    公开(公告)号：US5508396A

    公开(公告)日：1996-04-16

    申请号：US421237

    申请日：1995-04-13

    申请人： Klaus-Dieter Steffen

    发明人： Klaus-Dieter Steffen

    IPC分类号： C07D207/26 ,  C07D207/267 ,  C07D227/08 ,  C07D223/06

    CPC分类号： C07D207/267 ,  C07D227/08 ,  Y02P20/582

    摘要： A process for preparing an N-alkyllactam, comprising the steps of:(a) reacting a lactam with an alkali metal alkoxide at 130.degree.-170.degree. C. and removing the alcohol formed by distillation;(b) reacting the product from step (a), if desired in a mixture with the product from step (e), with an alkyl halide in a solvent which is(i) an ethylene glycol dialkyl ether of the formula R--O--(CH.sub.2 --CH.sub.2 --O).sub.m R, where R in C.sub.1 -C.sub.4 -alkyl and m is 1-8,(ii) the N-alkyllactam to be prepared or(iii) a mixture of (i) and (ii), to obtain crude N-alkylactam or an alkali metal salt;(c) separating the alkali metal salt from the crude N-alkylactam;(d) subjecting the N-alkyllactam crude product to high-purity distillation after addition of a sufficient amount of alkali metal alkoxide to convert any unreacted lactam to a salt; and(e) recycling the bottom product of the distillation in step (d) in step (e) into step (b), is environmentally friendly and affords the desired N-alkyllactam in high yield and high purity.

    摘要翻译： 一种制备N-烷基内酰胺的方法，包括以下步骤：（a）使内酰胺与碱金属醇盐在130-170℃反应并除去通过蒸馏形成的醇; （b）如果需要，与步骤（e）的产物的混合物中的步骤（a）的产物与烷基卤化物在溶剂中反应，所述溶剂是（ⅰ）式RO-（CH 2 -CH 2 -O）m R，其中C 1 -C 4烷基中的R和m为1-8，（ii）待制备的N-烷基内酰胺或（iii）（i）和（ii）的混合物，得到粗品 N-烷基内酰胺或碱金属盐; （c）从粗N-烷基内酰胺中分离碱金属盐; （d）在加入足够量的碱金属醇盐之后使N-烷基内酰胺粗产物进行高纯度蒸馏以将任何未反应的内酰胺转化为盐; 和（e）将步骤（d）中的步骤（d）中的蒸馏的底部产物再循环到步骤（b）中是环境友好的，并以高产率和高纯度提供所需的N-烷基内酰胺。