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    Methods and Computer Software Products for Identifying Transcribed Regions of a Genome
    4.
    发明申请
    Methods and Computer Software Products for Identifying Transcribed Regions of a Genome 审中-公开
    用于识别基因组转录区域的方法和计算机软件产品

    公开(公告)号：US20110250602A1

    公开(公告)日：2011-10-13

    申请号：US13167520

    申请日：2011-06-23

    申请人： Carsten Rosenow ,  Thomas Gingeras

    发明人： Carsten Rosenow ,  Thomas Gingeras

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6834 ,  C12Q1/68 ,  C12Q1/689 ,  G16B25/00 ,  G16B30/00 ,  C12Q2535/125

    摘要： Methods and computer software products are provided for transcriptional annotation. In one embodiment of the invention, a region of the genome where the intensity of hybridization of all the probes are above a threshold value (usually the level of non-specific hybridization) is identified. The region may be identified by aligning the probes against the genome; walking through the genome to find regions where all consecutive probes have intensities above the threshold value.

    摘要翻译： 提供方法和计算机软件产品用于转录注释。 在本发明的一个实施方案中，鉴定了所有探针的杂交强度高于阈值（通常为非特异性杂交水平）的基因组区域。 可以通过将探针与基因组对准来鉴定该区域; 走遍基因组，找到所有连续探针具有高于阈值的强度的区域。

    Methods and computer software products for identifying transcribed regions of a genome
    5.
    发明申请
    Methods and computer software products for identifying transcribed regions of a genome 审中-公开
    用于鉴定基因组转录区域的方法和计算机软件产品

    公开(公告)号：US20050136420A1

    公开(公告)日：2005-06-23

    申请号：US10815333

    申请日：2004-03-31

    申请人： Carsten Rosenow ,  Thomas Gingeras

    发明人： Carsten Rosenow ,  Thomas Gingeras

    IPC分类号： C12Q1/68 ,  G06F19/00 ,  G01N33/48 ,  G01N33/50

    CPC分类号： C12Q1/6834 ,  C12Q1/68 ,  C12Q1/689 ,  G16B25/00 ,  G16B30/00 ,  C12Q2535/125

    摘要： Methods and computer software products are provided for transcriptional annotation. In one embodiment of the invention, a region of the genome where the intensity of hybridization of all the probes are above a threshold value (usually the level of non-specific hybridization) is identified. The region may be identified by aligning the probes against the genome; walking through the genome to find regions where all consecutive probes have intensities above the threshold value.

    摘要翻译： 提供方法和计算机软件产品用于转录注释。 在本发明的一个实施方案中，鉴定了所有探针的杂交强度高于阈值（通常为非特异性杂交水平）的基因组区域。 可以通过将探针与基因组对准来鉴定该区域; 走遍基因组，找到所有连续探针具有高于阈值的强度的区域。

    Methods and Computer Software Products for Identifying Transcribed Regions of a Genome
    6.
    发明申请
    Methods and Computer Software Products for Identifying Transcribed Regions of a Genome 审中-公开
    用于识别基因组转录区域的方法和计算机软件产品

    公开(公告)号：US20070122838A1

    公开(公告)日：2007-05-31

    申请号：US11669344

    申请日：2007-01-31

    申请人： Carsten Rosenow ,  Thomas Gingeras

    发明人： Carsten Rosenow ,  Thomas Gingeras

    IPC分类号： C12Q1/68 ,  G06F19/00

    CPC分类号： C12Q1/6834 ,  C12Q1/68 ,  C12Q1/689 ,  G16B25/00 ,  G16B30/00 ,  C12Q2535/125

    摘要： Methods and computer software products are provided for transcriptional annotation. In one embodiment of the invention, a region of the genome where the intensity of hybridization of all the probes are above a threshold value (usually the level of non-specific hybridization) is identified. The region may be identified by aligning the probes against the genome; walking through the genome to find regions where all consecutive probes have intensities above the threshold value.

    摘要翻译： 提供方法和计算机软件产品用于转录注释。 在本发明的一个实施方案中，鉴定了所有探针的杂交强度高于阈值（通常为非特异性杂交水平）的基因组区域。 可以通过将探针与基因组对准来鉴定该区域; 走遍基因组，找到所有连续探针具有高于阈值的强度的区域。

    Method for detecting transcription templates
    7.
    发明授权
    Method for detecting transcription templates 有权

    公开(公告)号：US06670122B2

    公开(公告)日：2003-12-30

    申请号：US09683221

    申请日：2001-12-03

    申请人： Carsten Rosenow ,  Rini Saxena

    发明人： Carsten Rosenow ,  Rini Saxena

    IPC分类号： C12Q168

    CPC分类号： C12Q1/6837 ,  C12Q2521/107

    摘要： Methods are provided for detecting the sense and antisense transcripts and for determining template strand of a genomic DNA. Exemplary methods include reverse transcribing transcripts without second strand synthesis. The resulting single stranded DNA is labeled and detected using nucleic acid probe arrays. In a particularly embodiment, actinomycin is used to inhibit the synthesis of second strand cDNA during reverse transcription.

    Choline binding proteins for anti-pneumococcal vaccines
    9.
    发明申请
    Choline binding proteins for anti-pneumococcal vaccines 有权
    用于抗肺炎球菌疫苗的胆碱结合蛋白

    公开(公告)号：US20050048590A1

    公开(公告)日：2005-03-03

    申请号：US10901305

    申请日：2004-07-28

    申请人： H. Masure ,  Carsten Rosenow ,  Elaine Tuomanen ,  Theresa Wizemann

    发明人： H. Masure ,  Carsten Rosenow ,  Elaine Tuomanen ,  Theresa Wizemann

    IPC分类号： A61K38/00 ,  A61K39/00 ,  A61K39/395 ,  A61K48/00 ,  A61P31/04 ,  C07H21/04 ,  C07K14/315 ,  C12N1/21 ,  C12N15/31 ,  G01N33/569 ,  C12N15/74 ,  G01N33/554

    CPC分类号： G01N33/56944 ,  A61K38/00 ,  A61K39/00 ,  A61K39/3955 ,  A61K48/00 ,  A61K2039/505 ,  A61K2039/51 ,  A61K2039/53 ,  C07H21/04 ,  C07K14/3156 ,  Y10S530/825

    摘要： The invention relates to bacterial choline binding proteins (CBPs) which bind choline. Such proteins are particularly desirable for vaccines against appropriate strains of Gram positive bacteria, particularly streptococcus, and more particularly pneumococcus. Also provided are DNA sequences encoding the bacterial choline binding proteins or fragment thereof, antibodies to the bacterial choline binding proteins, pharmaceutical compositions comprising the bacterial choline binding proteins, antibodies to the bacterial choline binding proteins suitable for use in passive immunization, and small molecule inhibitors of choline binding protein mediated adhesion. Methods for diagnosing the presence of the bacterial choline binding protein, or of the bacteria, are also provided. In a specific embodiment, a streptococcal choline binding protein is an enolase, which demonstrates strong affinity for fibronectin.

    摘要翻译： 本发明涉及结合胆碱的细菌胆碱结合蛋白（CBP）。 对于针对革兰氏阳性菌，特别是链球菌，更特别是肺炎球菌的合适菌株的疫苗，这种蛋白质是特别需要的。 还提供了编码细菌胆碱结合蛋白或其片段的DNA序列，细菌胆碱结合蛋白的抗体，包含细菌胆碱结合蛋白的药物组合物，适用于被动免疫的细菌胆碱结合蛋白的抗体和小分子抑制剂 的胆碱结合蛋白介导的粘附。 还提供了用于诊断细菌胆碱结合蛋白或细菌存在的方法。 在具体实施方案中，链球菌胆碱结合蛋白是烯醇化酶，其对纤连蛋白表现出强亲和力。