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公开(公告)号：US06620413B1
公开(公告)日：2003-09-16
申请号：US08775066
申请日：1996-12-27
申请人： Frederic DeSauvage , Nancy Levin , Richard Vandlen
发明人： Frederic DeSauvage , Nancy Levin , Richard Vandlen
IPC分类号： A61K39395
CPC分类号： C07K19/00 , A61K38/00 , C07K14/5759 , C07K2319/30
摘要： The present invention concerns long-half derivative of the obesity protein OB. The invention specifically concerns OB protein-immunoglobulin chimeras and polyethylene glycol (PEG)-OB derivatives, which have extended half-life as compared to the corresponding native OB proteins. The invention further relates to methods for treating obesity by using the long half-life derivatives of OB.
摘要翻译： 本发明涉及肥胖蛋白质OB的长半衍生物。 本发明特别涉及与相应的天然OB蛋白相比延长半衰期的OB蛋白 - 免疫球蛋白嵌合体和聚乙二醇（PEG）-OB衍生物。 本发明还涉及通过使用OB的长半衰期衍生物来治疗肥胖症的方法。
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2.发明授权Chimpanzee erythropoietin (CHEPO) polypeptides and nucleic acids encoding the same 有权黑猩猩促红细胞生成素（CHEPO）多肽和编码其的核酸公开(公告)号：US06831060B2
公开(公告)日：2004-12-14
申请号：US09813775
申请日：2001-03-20
IPC分类号： A61K3816
CPC分类号： C07K14/505 , A61K38/00 , A61K48/00 , C07K2319/00
摘要： The present invention is directed to novel chimpanzee erythropoietin polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, and antibodies which bind to the polypeptides of the present invention.
摘要翻译： 本发明涉及新型黑猩猩红细胞生成素多肽和编码这些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明多肽的嵌合多肽分子，以及结合本发明多肽的抗体。
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3.发明授权Chimpanzee erythropoietin (CHEPO) polypeptides and nucleic acids encoding the same 有权黑猩猩促红细胞生成素（CHEPO）多肽和编码其的核酸公开(公告)号：US06555343B1
公开(公告)日：2003-04-29
申请号：US09552265
申请日：2000-04-19
IPC分类号： C12N1509
CPC分类号： C07K14/505 , A61K38/00 , A61K48/00 , C07K2319/00 , Y10S977/773 , Y10S977/907
摘要： The present invention is directed to novel chimpanzee erythropoietin polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及新型黑猩猩红细胞生成素多肽和编码这些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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公开(公告)号：US20070053835A1
公开(公告)日：2007-03-08
申请号：US11538764
申请日：2006-10-04
申请人： Frederic DeSauvage , Gretchen Frantz , Kenneth Hillan , Paul Polakis , Andrew Polson , Victoria Smith , Susan Spencer , Thomas Wu , Zemin Zhang
发明人： Frederic DeSauvage , Gretchen Frantz , Kenneth Hillan , Paul Polakis , Andrew Polson , Victoria Smith , Susan Spencer , Thomas Wu , Zemin Zhang
IPC分类号： A61K51/00 , A61K39/395 , C07K16/46 , C07K16/30
CPC分类号： C07K16/30 , A61K47/6803 , A61K47/6809 , A61K47/6843 , A61K47/6851 , A61K2039/505
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号：US20050064492A1
公开(公告)日：2005-03-24
申请号：US10948518
申请日：2004-09-22
申请人： Frederic DeSauvage , Gretchen Frantz , Kenneth Hillan , Paul Polakis , Andrew Polson , Victoria Smith , Susan Spencer , Thomas Wu , Zemin Zhang
发明人： Frederic DeSauvage , Gretchen Frantz , Kenneth Hillan , Paul Polakis , Andrew Polson , Victoria Smith , Susan Spencer , Thomas Wu , Zemin Zhang
IPC分类号： A61K47/48 , C07K16/30 , C12Q1/68 , C12P19/34 , G01N33/574
CPC分类号： C07K16/30 , A61K47/6803 , A61K47/6809 , A61K47/6843 , A61K47/6851 , A61K2039/505
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号：US20090280082A1
公开(公告)日：2009-11-12
申请号：US12395550
申请日：2009-02-27
申请人： Nico GHILARDI , Frederic DeSauvage
发明人： Nico GHILARDI , Frederic DeSauvage
CPC分类号： C07K16/2866 , A61K38/20 , A61K38/208 , A61K2039/505 , C07K2317/74 , G01N2333/715 , G01N2500/04 , G01N2800/24
摘要： The present invention relates to methods for treating autoimmune disorders. In an embodiment, the invention is directed to a method for treating an autoimmune disorder comprising administering a TCCR agonist. In an embodiment, the autoimmune disorder is at least partially mediated by a Th1 response. In an embodiment, the autoimmune disorder is at least partially mediated by CD8+ T-cell proliferation.
摘要翻译： 本发明涉及治疗自身免疫性疾病的方法。 在一个实施方案中，本发明涉及治疗自身免疫疾病的方法，包括施用TCCR激动剂。 在一个实施方案中，自身免疫疾病至少部分地由Th1应答介导。 在一个实施方案中，自身免疫疾病至少部分地由CD8 + T细胞增殖介导。
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公开(公告)号：US20060177436A1
公开(公告)日：2006-08-10
申请号：US11275181
申请日：2005-12-16
申请人： Nico Ghilardi , Frederic DeSauvage
发明人： Nico Ghilardi , Frederic DeSauvage
IPC分类号： A61K39/395
CPC分类号： C07K16/2866 , A61K38/20 , A61K38/208 , A61K2039/505 , C07K2317/74 , G01N2333/715 , G01N2500/04 , G01N2800/24
摘要： The present invention relates to methods for treating autoimmune disorders. In an embodiment, the invention is directed to a method for treating an autoimmune disorder comprising administering a TCCR agonist. In an embodiment, the autoimmune disorder is at least partially mediated by a Th1 response. In an embodiment, the autoimmune disorder is at least partially mediated by CD8+ T-cell proliferation.
摘要翻译： 本发明涉及治疗自身免疫性疾病的方法。 在一个实施方案中，本发明涉及治疗自身免疫疾病的方法，包括施用TCCR激动剂。 在一个实施方案中，自身免疫疾病至少部分地由Th1应答介导。 在一个实施方案中，自身免疫疾病至少部分地由CD8 + T细胞增殖介导。
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