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58 条记录 (耗时 0.086 秒)

    METHODS FOR THE TREATMENT OF CARCINOMA
    1.
    发明申请
    METHODS FOR THE TREATMENT OF CARCINOMA 审中-公开

    公开(公告)号：US20070141068A1

    公开(公告)日：2007-06-21

    申请号：US11671987

    申请日：2007-02-06

    申请人： Mary Gerritsen ,  Franklin Peale ,  Thomas Wu

    发明人： Mary Gerritsen ,  Franklin Peale ,  Thomas Wu

    IPC分类号： A61K39/395 ,  C07K16/30

    CPC分类号： G01N33/57438 ,  A61K48/00 ,  A61K2039/505 ,  C07K14/82 ,  C07K16/30 ,  C07K16/3076 ,  G01N33/57484 ,  G01N2333/726 ,  G01N2500/00

    摘要： The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based upon the identification of genes that are amplified in the genome of tumor cells, such as renal cell carcinoma. Such gene amplification is expected to be associated with the overexpression of the gene product as compared to normal cells of the same tissue type and contribute to tumorigenesis. Accordingly, the proteins encoded by the amplified genes are believed to be useful targets for the diagnosis and/or treatment (including prevention) of certain cancers, such as renal cell carcinoma, and may act as predictors of the prognosis of tumor treatment. The present invention is directed to novel methods of diagnosing and treating tumor, such as renal cell carcinoma or Wilms tumor.

    METHODS FOR THE TREATMENT OF CARCINOMA
    2.
    发明申请
    METHODS FOR THE TREATMENT OF CARCINOMA 审中-公开
    治疗癌症的方法

    公开(公告)号：US20070020276A1

    公开(公告)日：2007-01-25

    申请号：US11530830

    申请日：2006-09-11

    申请人： Mary Gerritsen ,  Franklin Peale ,  Thomas Wu

    发明人： Mary Gerritsen ,  Franklin Peale ,  Thomas Wu

    IPC分类号： A61K39/395 ,  G01N33/574 ,  C07H21/04 ,  C12P21/06 ,  C12N5/06 ,  C07K16/30

    CPC分类号： G01N33/57438 ,  A61K48/00 ,  A61K2039/505 ,  C07K14/82 ,  C07K16/30 ,  C07K16/3076 ,  G01N33/57484 ,  G01N2333/726 ,  G01N2500/00

    摘要： The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based upon the identification of genes that are amplified in the genome of tumor cells, such as renal cell carcinoma. Such gene amplification is expected to be associated with the overexpression of the gene product as compared to normal cells of the same tissue type and contribute to tumorigenesis. Accordingly, the proteins encoded by the amplified genes are believed to be useful targets for the diagnosis and/or treatment (including prevention) of certain cancers, such as renal cell carcinoma, and may act as predictors of the prognosis of tumor treatment. The present invention is directed to novel methods of diagnosing and treating tumor, such as renal cell carcinoma or Wilms tumor.

    摘要翻译： 本发明涉及用于诊断和治疗哺乳动物包括人类的肿瘤细胞生长和增殖的组合物和方法。 本发明基于在肿瘤细胞如肾细胞癌基因组中扩增的基因的鉴定。 预期这种基因扩增与相同组织类型的正常细胞相比，与基因产物的过表达有关，并且有助于肿瘤发生。 因此，由扩增的基因编码的蛋白质被认为是某些癌症如肾细胞癌的诊断和/或治疗（包括预防）的有用靶标，并且可以作为肿瘤治疗预后的预测因子。 本发明涉及新型的诊断和治疗肿瘤的方法，例如肾细胞癌或Wilms肿瘤。

    METHODS FOR THE TREATMENT OF CARCINOMA
    3.
    发明申请
    METHODS FOR THE TREATMENT OF CARCINOMA 审中-公开
    治疗癌症的方法

    公开(公告)号：US20070026450A1

    公开(公告)日：2007-02-01

    申请号：US11535366

    申请日：2006-09-26

    申请人： Mary Gerritsen ,  Franklin Peale ,  Thomas Wu

    发明人： Mary Gerritsen ,  Franklin Peale ,  Thomas Wu

    IPC分类号： C12Q1/68 ,  G01N33/574 ,  C12P21/06 ,  C12N5/06 ,  C07K16/40 ,  C07K16/30

    CPC分类号： C07K16/2866

    摘要： The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based upon the identification of genes that are amplified in the genome of tumor cells, such as renal cell carcinoma. Such gene amplification is expected to be associated with the overexpression of the gene product as compared to normal cells of the same tissue type and contribute to tumorigenesis. Accordingly, the proteins encoded by the amplified genes are believed to be useful targets for the diagnosis and/or treatment (including prevention) of certain cancers, such as renal cell carcinoma, and may act as predictors of the prognosis of tumor treatment. The present invention is directed to novel methods of diagnosing and treating tumor, such as renal cell carcinoma.

    摘要翻译： 本发明涉及用于诊断和治疗哺乳动物包括人类的肿瘤细胞生长和增殖的组合物和方法。 本发明基于在肿瘤细胞如肾细胞癌基因组中扩增的基因的鉴定。 预期这种基因扩增与相同组织类型的正常细胞相比，与基因产物的过表达有关，并且有助于肿瘤发生。 因此，由扩增的基因编码的蛋白质被认为是某些癌症如肾细胞癌的诊断和/或治疗（包括预防）的有用靶标，并且可以作为肿瘤治疗预后的预测因子。 本发明涉及新型的诊断和治疗肿瘤的方法，如肾细胞癌。

    ErbB4 antagonists
    4.
    发明申请
    ErbB4 antagonists 审中-公开
    ErbB4拮抗剂

    公开(公告)号：US20070092513A1

    公开(公告)日：2007-04-26

    申请号：US11581221

    申请日：2006-10-13

    申请人： Mary Gerritsen ,  Mark Sliwkowski

    发明人： Mary Gerritsen ,  Mark Sliwkowski

    IPC分类号： A61K39/395

    CPC分类号： C07K14/82 ,  A61K38/00 ,  C07K14/4756 ,  C07K16/32 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00 ,  C07K2319/30 ,  G01N33/5061

    摘要： The present invention concerns methods and means for controlling excessive proliferation and/or migration of smooth muscle cells, and in particular for treating stenosis, by using antagonists of a native ErbB4 receptor. The invention further concerns a method for the identification of ErbB4 agonists and antagonists capable of inhibiting or enhancing the proliferation or migration of smooth muscle cells.

    摘要翻译： 本发明涉及通过使用天然ErbB4受体的拮抗剂来控制平滑肌细胞的过度增殖和/或迁移，特别是用于治疗狭窄的方法和手段。 本发明还涉及鉴定能够抑制或增强平滑肌细胞增殖或迁移的ErbB4激动剂和拮抗剂的方法。