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1.发明授权
公开(公告)号：US6144200A
公开(公告)日：2000-11-07
申请号：US27519
申请日：1998-02-20
IPC分类号： A61B5/055 , G01R33/32 , G01R33/48 , G01R33/561 , G01V3/00
CPC分类号： G01R33/5615 , G01R33/5616
摘要： A method is disclosed to reconstruct multiphase MR images that accurately depict the entire cardiac cycle. A segmented, echo-planar imaging (EPI) pulse sequence is used to acquire data continuously during each cardiac cycle. Images are retrospectively reconstructed by selecting views from each heartbeat based on cardiac phase.
摘要翻译： 公开了一种重建准确描绘整个心动周期的多相MR图像的方法。 使用分段回波平面成像（EPI）脉冲序列在每个心动周期期间连续获取数据。 通过基于心脏相位选择来自每个心跳的视图来回顾性地重建图像。
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2.发明授权Method for extracting deformations from velocity-encoded magnetic resonance images of the heart 失效从心脏的速度编码磁共振图像中提取变形的方法
公开(公告)号：US6031374A
公开(公告)日：2000-02-29
申请号：US937725
申请日：1997-09-25
IPC分类号： G01R33/48 , A61B5/055 , G01R33/563 , G01R33/567 , G01V3/00
CPC分类号： A61B5/7207 , A61B5/055 , G01R33/56308 , G01R33/5673
摘要： An MRI scan is conducted in which velocity encoded NMR data is acquired for a slice through the heart. Velocity images and magnitude images are reconstructed at multiple cardiac phases and masks are formed using the magnitude images. The masks are applied to the velocity images to isolate the left ventricle, and rigid body motion is calculated and subtracted from the masked velocity images to indicate deformation of the left ventricle.
摘要翻译： 进行MRI扫描，其中通过心脏获取速度编码的NMR数据。 在多个心脏相位处重建速度图像和幅度图像，并且使用幅度图像形成掩模。 将掩模应用于速度图像以分离左心室，并且计算刚体运动并从掩蔽的速度图像中减去以指示左心室的变形。
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3.发明授权
公开(公告)号：US05997883A
公开(公告)日：1999-12-07
申请号：US886487
申请日：1997-07-01
IPC分类号： A61B5/0456 , G01R33/567 , G01V3/00
CPC分类号： A61B5/7292 , G01R33/5673 , A61B5/0456 , A61B5/7289
摘要： A method is disclosed to reconstruct multiphase MR images that accurately depict the entire cardiac cycle. A segmented, gradient-recalled-echo sequence is modified to acquire data continuously. Images are retrospectively reconstructed by selecting views from each heartbeat based on cardiac phase rather than the time elapsed from the QRS complex. Cardiac phase is calculated using a model that compensates for beat-to-beat heart rate changes.
摘要翻译： 公开了一种重建准确描绘整个心动周期的多相MR图像的方法。 修改分段渐变回波序列以连续采集数据。 通过基于心脏相位而不是从QRS复合体经过的时间选择来自每个心跳的视图来回顾性地重建图像。 使用补偿搏动心跳变化的模型计算心脏相。
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4.发明申请NONINVASIVE METHODS FOR DETERMINING THE PRESURE GRADIENT ACROSS A HEART VALVE WITHOUT USING VELOCITY DATA AT THE VALVE ORIFICE 有权用于通过心脏瓣膜确定视力梯度的无创方法，不使用阀门上的速度数据公开(公告)号：US20130066229A1
公开(公告)日：2013-03-14
申请号：US13229742
申请日：2011-09-11
申请人： Steven D. Wolff
发明人： Steven D. Wolff
IPC分类号： A61B5/00
CPC分类号： A61B5/0044 , A61B5/02028 , A61B5/1079 , A61B5/7239 , A61B2576/00
摘要： Embodiments presented herein provide apparatus and methods for imaging-assisted determination of pressure gradient of blood flow across a valve orifice in a cardiovascular circuit without the use of velocity data measured at the valve orifice. An embodiment of the methods comprise creating an image of a valve orifice, creating a planimeter slice from the image of the valve orifice including a trace of the perimeter of the valve orifice, determining the valve orifice area by determining the area contained within the trace, determining the instantaneous flow rate through the valve orifice based on bulk flow data away from the valve, and determining the instantaneous pressure gradient across the valve orifice from the valve orifice area and the instantaneous flow rate.
摘要翻译： 本文提出的实施例提供了用于成像辅助确定在心血管电路中的瓣孔上的血流压力梯度的装置和方法，而不使用在阀孔处测量的速度数据。 所述方法的一个实施例包括创建阀孔的图像，从阀孔的图像创建平面图切片，包括阀孔的周边的痕迹，通过确定痕迹中包含的区域来确定阀孔面积， 基于离开阀的大量流动数据确定通过阀孔的瞬时流量，以及从阀孔面积和瞬时流量确定跨越阀孔的瞬时压力梯度。
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公开(公告)号：US07383074B2
公开(公告)日：2008-06-03
申请号：US10904272
申请日：2004-11-02
IPC分类号： A61B5/05
CPC分类号： A61B5/7285 , A61B5/055 , A61B5/7289 , G01R33/5611 , G01R33/5673
摘要： A system and method for MR imaging is disclosed that includes displaying a series of MR images of an ROI in real-time and localizing a slice within the ROI. The method also includes using a parallel imaging technique to acquire gated MR data from the localized slice and reconstructing a prescribed fixed number of gated MR images of the localized slice.
摘要翻译： 公开了一种用于MR成像的系统和方法，其包括实时地显示ROI的一系列MR图像并且在ROI内定位切片。 该方法还包括使用并行成像技术从局部切片获取门控MR数据，并重建局部切片的规定固定数量的门控MR图像。
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6.发明授权Method and apparatus for MR perfusion image acquisition using a notched RF saturation pulse 有权使用缺口RF饱和脉冲进行MR灌注图像采集的方法和装置公开(公告)号：US06618605B1
公开(公告)日：2003-09-09
申请号：US09391965
申请日：1999-09-08
IPC分类号： A61B5055
CPC分类号： G01R33/56341 , G01R33/4838
摘要： A method and apparatus is disclosed for MR perfusion acquisition using a notched RF saturation pulse. In acquiring such MR data, a volume of slice locations is selected in which MR data is to be acquired. Each given slice is prepared with a notched RF saturation pulse which has a stop-band between a pair of pass-bands. The stop-band is designed to not affect the spins in the next slice in which MR data is to be acquired thereby effectively increasing the TI and increasing SNR and contrast simultaneously. Since the notched saturation pulse saturates all the spins outside of the notched stop-band, the blood in the ventricular chamber is effectively saturated so that the resulting perfusion images have blood pool suppression. Additionally, the use of a 90° presaturation RF pulse provides a high level of immunity to the effects of arrhythmias or other variations in the patient's heart rate. In order to keep the stop-band, or the notch, as wide as possible to overlap the boundaries of each slice location, it is preferable to interleave the acquisition of slice locations.
摘要翻译： 公开了一种使用缺口RF饱和脉冲进行MR灌注采集的方法和装置。 在获取这样的MR数据时，选择要获取MR数据的片段位置量。 每个给定的切片用具有一对通带之间的阻带的缺口RF饱和脉冲来制备。 阻带被设计成不影响将要获取MR数据的下一个切片中的自旋，从而有效地增加TI并同时增加SNR和对比度。 由于缺口饱和脉冲饱和了缺口挡带外的所有旋转，所以心室内的血液被有效地饱和，使得所得到的灌注图像具有血液池抑制。 另外，90°预饱和RF脉冲的使用可以提供高度的抗心律失常作用或其他变化对患者心率的影响。 为了使阻带或陷波尽可能地保持与每个切片位置的边界重叠，优选地切片切片位置的获取。
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7.发明授权Local magnetization spoiling using a gradient insert for reducing the field of view in magnetic resonance imaging 有权使用梯度插入件进行局部磁化破坏，以减少磁共振成像中的视场公开(公告)号：US06384601B1
公开(公告)日：2002-05-07
申请号：US09403530
申请日：1999-10-19
申请人： David G. Wiesler , Han Wen , Robert S. Balaban , Steven D. Wolff
发明人： David G. Wiesler , Han Wen , Robert S. Balaban , Steven D. Wolff
IPC分类号： G01V300
CPC分类号： G01R33/4838
摘要： A method, and related apparatus, for suppressing the magnetic resonance signal to an experimentally adjustable depth by applying a spatially inhomogeneous field between the slice-select pulse and the data acquisition. Eliminating the signal from near surface regions allows one to shrink the field of view of an image without introducing aliasing artifacts, thereby improving the image's resolution or decreasing imaging time. Experimental tests on a phantom and a human subject indicate that the depth of signal suppression may be continuously varied to depths of over 80 millimeters with modest requirements on power supplies, pulse sequences, and materials.
摘要翻译： 一种通过在切片选择脉冲和数据采集之间施加空间不均匀场来将磁共振信号抑制到实验可调深度的方法和相关装置。 消除来自近表面区域的信号允许缩小图像的视野而不引入混叠伪像，从而改善图像的分辨率或降低成像时间。 对幻影和人类受试者进行的实验测试表明，信号的抑制深度可以连续地变化到超过80毫米的深度，对电源，脉冲序列和材料的要求不高。
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公开(公告)号：US20080132778A1
公开(公告)日：2008-06-05
申请号：US12024844
申请日：2008-02-01
IPC分类号： A61B5/055
CPC分类号： A61B5/7285 , A61B5/055 , A61B5/7289 , G01R33/5611 , G01R33/5673
摘要： A system and method for MR imaging is disclosed that includes displaying a series of MR images of an ROI in real-time and localizing a slice within the ROI. The method also includes using a parallel imaging technique to acquire gated MR data from the localized slice and reconstructing a prescribed fixed number of gated MR images of the localized slice.
摘要翻译： 公开了一种用于MR成像的系统和方法，其包括实时地显示ROI的一系列MR图像并且在ROI内定位切片。 该方法还包括使用并行成像技术从局部切片获取门控MR数据，并重建局部切片的规定固定数量的门控MR图像。
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9.发明授权Magnetization transfer contrast and proton relaxation and use thereof in magnetic resonance imaging 失效磁化转移对比度和质子松弛及其在磁共振成像中的应用
公开(公告)号：US5050609A
公开(公告)日：1991-09-24
申请号：US337980
申请日：1989-04-14
申请人： Robert S. Balaban , Steven D. Wolff
发明人： Robert S. Balaban , Steven D. Wolff
IPC分类号： G01R33/28 , G01R33/483 , G01R33/563
CPC分类号： G01R33/5605 , G01R33/4833
摘要： A nuclear magnetic resonance method is provided for monitoring and imaging the exchange of magnetization between protons in free water and protons in a relatively immobilized pool of protons in a sample. The method provides a new form of contrast for nuclear magnetic resonance imaging of samples such as biological tissues, polymers, and geological samples.
摘要翻译： 提供了核磁共振方法，用于监测和成像样品中质子相对固定的质子池中游离水质子与质子之间的磁化交换。 该方法为生物组织，聚合物和地质样品等样品的核磁共振成像提供了新的对比形式。
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10.发明授权Noninvasive methods for determining the pressure gradient across a heart valve without using velocity data at the valve orifice 有权用于确定心脏瓣膜上的压力梯度的无创方法，而不使用阀口处的速度数据公开(公告)号：US09585568B2
公开(公告)日：2017-03-07
申请号：US13229742
申请日：2011-09-11
申请人： Steven D. Wolff
发明人： Steven D. Wolff
CPC分类号： A61B5/0044 , A61B5/02028 , A61B5/1079 , A61B5/7239 , A61B2576/00
摘要： Embodiments presented herein provide apparatus and methods for imaging-assisted determination of pressure gradient of blood flow across a valve orifice in a cardiovascular circuit without the use of velocity data measured at the valve orifice. An embodiment of the methods comprise creating an image of a valve orifice, creating a planimeter slice from the image of the valve orifice including a trace of the perimeter of the valve orifice, determining the valve orifice area by determining the area contained within the trace, determining the instantaneous flow rate through the valve orifice based on bulk flow data away from the valve, and determining the instantaneous pressure gradient across the valve orifice from the valve orifice area and the instantaneous flow rate.
摘要翻译： 本文提出的实施例提供了用于成像辅助确定在心血管电路中的瓣孔上的血流压力梯度的装置和方法，而不使用在阀孔处测量的速度数据。 所述方法的一个实施例包括创建阀孔的图像，从阀孔的图像创建平面图切片，包括阀孔的周边的痕迹，通过确定痕迹中包含的区域来确定阀孔面积， 基于离开阀的大量流动数据确定通过阀孔的瞬时流量，以及从阀孔面积和瞬时流量确定跨越阀孔的瞬时压力梯度。
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