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    Amino derivatives of 3-alkyl-5-(2-hydroxystyryl)-isoxazoles
    1.
    发明授权
    Amino derivatives of 3-alkyl-5-(2-hydroxystyryl)-isoxazoles 失效
    3-烷基-5-（2-羟基苯乙烯基） - 异恶唑的氨基衍生物

    公开(公告)号：US4251539A

    公开(公告)日：1981-02-17

    申请号：US30927

    申请日：1979-04-17

    申请人： Peter C. Thieme ,  Fritz-Frieder Frickel ,  Hans Theobald ,  Albrecht Franke ,  Dieter Lenke ,  Josef Gries

    发明人： Peter C. Thieme ,  Fritz-Frieder Frickel ,  Hans Theobald ,  Albrecht Franke ,  Dieter Lenke ,  Josef Gries

    IPC分类号： A61K31/42 ,  A61P9/00 ,  A61P9/06 ,  A61P9/12 ,  A61P25/02 ,  C07D261/08

    CPC分类号： C07D261/08

    摘要： Alkylamino-propanol derivatives of 3-alkyl-5-(2-hydroxystyryl)-isoxazole, of the general formula ##STR1## where R is hydrogen, alkyl of 1 to 8 carbon atoms, which is unsubstituted or substituted by hydroxyl, alkoxy of 1 to 3 carbon atoms or cycloalkyl with 3 to 8 carbon atoms in the ring, alkenyl or alkynyl of 2 to 8 carbon atoms, or cycloalkyl with 3 to 8 carbon atoms in the ring, the cycloalkyl rings being unsubstituted or mono- or di-substituted by alkyl of 1 to 3 carbon atoms, and R' is alkyl of 1 to 4 carbon atoms, and their addition salts with physiologically acceptable acids, their preparation, and pharmaceutical formulations which contain these compounds and which can be used as valuable drugs in the treatment of hypertonia, coronary diseases of the heart and cardiac arrhythmias.

    摘要翻译： 3-烷基-5-（2-羟基苯乙烯基） - 异恶唑的通式为：其中R为氢的烷基氨基丙醇衍生物，未取代或被羟基取代的碳原子数为1至8的烷基，烷氧基为1 至3个碳原子或环中具有3至8个碳原子的环烷基，2至8个碳原子的链烯基或炔基或环中具有3至8个碳原子的环烷基，环烷基环为未取代的或单或二取代的 具有1至3个碳原子的烷基，R'是1至4个碳原子的烷基，以及它们与生理上可接受的酸的加成盐，它们的制备方法和含有这些化合物的药物制剂，并且可以在 治疗高血压，心脏冠状动脉疾病和心律失常。

    Aminopropanol derivatives of 2-(0-hydroxyphenyl)-pyrrole
    7.
    发明授权
    Aminopropanol derivatives of 2-(0-hydroxyphenyl)-pyrrole 失效
    2-（O-羟基苯基） - 吡咯的氨基丙醇衍生物

    公开(公告)号：US4267187A

    公开(公告)日：1981-05-12

    申请号：US64907

    申请日：1979-08-08

    申请人： Fritz-Frieder Frickel ,  Albrecht Franke ,  Horst Koenig ,  Hans-Dieter Lenke ,  Josef Gries

    发明人： Fritz-Frieder Frickel ,  Albrecht Franke ,  Horst Koenig ,  Hans-Dieter Lenke ,  Josef Gries

    IPC分类号： A61K31/40 ,  A61P9/00 ,  C07D207/32 ,  C07D207/333

    CPC分类号： C07D207/333

    摘要： Alkylaminopropanol derivatives of 2-(o-hydroxyphenyl)-pyrrole of the formula (I) ##STR1## where R is hydrogen or is alkyl of 1 to 8 carbon atoms which is unsubstituted or substituted by hydroxyl, alkoxy of 1 to 3 carbons atoms or cycloalkyl of 3 to 8 carbon atoms in the ring, or is alkenyl or alkynyl of 2 to 8 carbon atoms or is cycloalkyl or cycloalkenyl of 3 to 8 carbon atoms in the ring, the cycloalkyl rings being unsubstituted or monosubstituted or disubstituted by alkyl or 1 to 3 carbon atoms, and their physiologically acceptable acid addition salts, processes for their preparation, and pharmaceutical formulations which contain the said compounds and may be used in the treatment of cardiac and circulatory disorders.

    摘要翻译： 式（I）的2-（邻羟基苯基） - 吡咯的烷基氨基丙醇衍生物其中R是氢或未被取代或被羟基取代的1至8个碳原子的烷基，1至3的烷氧基 碳原子或碳原子数为3〜8的环烷基，或碳原子数为2〜8的烯基或炔基，或为环中具有3-8个碳原子的环烷基或环烯基，环烷基环为未被取代或被单取代或二取代的 烷基或1至3个碳原子，以及它们的生理上可接受的酸加成盐，其制备方法和含有所述化合物的药物制剂，并且可用于治疗心脏和循环系统疾病。