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    Imide derivatives and their production and use
    4.
    发明授权
    Imide derivatives and their production and use 失效
    酰亚胺衍生物及其生产和使用

    公开(公告)号：US5780632A

    公开(公告)日：1998-07-14

    申请号：US634738

    申请日：1996-04-18

    申请人： Ikutaro Saji ,  Masayuki Muto ,  Norihiko Tanno ,  Mayumi Yoshigi

    发明人： Ikutaro Saji ,  Masayuki Muto ,  Norihiko Tanno ,  Mayumi Yoshigi

    IPC分类号： A61K31/445 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/47 ,  A61K31/495 ,  A61K31/505 ,  A61P25/18 ,  A61P25/20 ,  C07D207/40 ,  C07D209/48 ,  C07D209/54 ,  C07D209/76 ,  C07D221/20 ,  C07D275/06 ,  C07D401/08 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/08 ,  C07D417/12 ,  C07D417/14 ,  C07D487/04 ,  C07D491/18 ,  C07D493/08 ,  C07D405/14 ,  C07D413/14

    CPC分类号： C07D209/48 ,  C07D275/06 ,  C07D401/08 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/10 ,  C07D413/12 ,  C07D417/12 ,  C07D493/08

    摘要： An imide compound of the formula: ##STR1## wherein Z is a group of the formula: ##STR2## in which B is a carbonyl group or a sulfonyl group, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are each a hydrogen atom or a lower alkyl group, or R.sup.1 and R.sup.2 or R.sup.1 and R.sup.3 may be combined together to make a non-aromatic hydrocarbon ring or R.sup.1 and R.sup.3 may be combined together to make an aromatic ring, said non-aromatic hydrocarbon ring being optionally bridged with a lower alkylene group or an oxygen atom therein and said aromatic ring, said non-aromatic hydrocarbon ring and said lower alkylene group being each optionally substituted with at least one lower alkyl, and n is an integer of 0 or 1; D is a group of the formula: --(CH.sub.2).sub.p --A--(CH.sub.2).sub.q -- in which A is a non-aromatic hydrocarbon ring optionally bridged with a lower alkylene group or an oxygen atom, said non-aromatic hydrocarbon ring and said lower alkylene group being each optionally substituted with at least one lower alkyl, and p and q are each an integer of 0, 1 or 2; and Ar is an aromatic group, a heterocyclic aromatic group, a benzoyl group, a phenoxy group or a phenylthio group and G is ##STR3## or Ar is a biphenylmethylidene group and G is ##STR4## all of the above groups being each optionally substituted with at least one of lower alkyl, lower alkoxy and halogen; and its acid addition salts, useful as an antipsycotic agent.

    摘要翻译： 下式的酰亚胺化合物：其中Z是下式的基团：其中B是羰基或磺酰基，R1，R2，R3和R4各自是氢原子或 低级烷基或R 1和R 2或R 1和R 3可以结合在一起以制备非芳族烃环，或者R 1和R 3可以组合在一起以形成芳族环，所述非芳族烃环任选地与 低级亚烷基或氧原子，所述芳环，所述非芳族烃环和所述低级亚烷基各自任选被至少一个低级烷基取代，n为0或1的整数; D是下式的基团： - （CH 2）p -A（CH 2）q - ，其中A是任选与低级亚烷基或氧原子桥连的非芳族烃环，所述非芳族烃环和所述低级 亚烷基各自任选被至少一个低级烷基取代，p和q各自为0,1或2的整数; Ar是芳基，杂环芳基，苯甲酰基，苯氧基或苯硫基，G是或Ar是联苯亚甲基，G是所有上述基团各自任意取代的 与至少一种低级烷基，低级烷氧基和卤素; 和其酸加成盐，可用作抗精神病药。

    Thiazole derivatives
    7.
    发明授权
    Thiazole derivatives 失效
    噻唑衍生物

    公开(公告)号：US5258396A

    公开(公告)日：1993-11-02

    申请号：US871800

    申请日：1992-04-21

    申请人： Hiroaki Masumori ,  Norihiko Tanno ,  Ikutaro Saji ,  Yoshihiko Kimura

    发明人： Hiroaki Masumori ,  Norihiko Tanno ,  Ikutaro Saji ,  Yoshihiko Kimura

    IPC分类号： C07D277/40 ,  C07D277/42 ,  C07D277/48 ,  C07D277/56 ,  A61K31/425

    CPC分类号： C07D277/56 ,  C07D277/40 ,  C07D277/42 ,  C07D277/48

    摘要： A novel thiazole derivative represented by the following general formula [1] and a pharmaceutically acceptable salt thereof: ##STR1## wherein A is a single bond, a straight-chained or branched lower alkylene group or a straight-chained or branched lower alkenylene group; B is a single bond or --CO--; R.sup.1 is a carboxy group or --CON(R.sup.7)OR.sup.8 (R.sup.7 and R.sup.8 are independently of each other a hydrogen atom or a lower alkyl group); R.sup.2 is a lower alkyl group; R.sup.3 and R.sup.4 are independently of each other a hydrogen atom, a lower alkyl group or a lower alkoxycarbonyl group; R.sup.5 is a hydrogen atom or a halogen atom; and R.sup.6 is a hydrogen atom, a halogen atom, a lower alkyl group, a hydroxy group, a lower alkoxy group, a thiol group, a lower alkylthio group, a lower alkylsulfinyl group, a lower alkylsulfonyl group, a nitro group, an amino group, a substituted amino group, a cyano group, a carboxy group or an acyl group.The compounds of the present invention are useful as therapeutic or preventive drugs for autoimmune diseases and inflammatory diseases.