公开(公告)号：US20100261911A1

公开(公告)日：2010-10-14

申请号：US12682090

申请日：2008-10-16

申请人： Kenji Oki ,  Fumio Tsuji ,  Chikako Setoguchi ,  Iwao Seki ,  Masaaki Murai ,  Minoru Sasano

发明人： Kenji Oki ,  Fumio Tsuji ,  Chikako Setoguchi ,  Iwao Seki ,  Masaaki Murai ,  Minoru Sasano

IPC分类号： C07D213/40

CPC分类号： A61K31/4409 ,  A61K31/44 ,  C07D213/36

摘要： An object of the present invention is to find a novel pharmacological action of a urea compound having a structure represented by the general formula [I]. The urea compound having a structure represented by the general formula [I] or a salt thereof has an excellent therapeutic effect on a TRPV1-mediated disease. In the formula, A represents a lower alkylene group or a lower alkenylene group; R1 represents a hydrogen atom, an alkyl group which may have a substituent or an alkenyl group which may have a substituent; and R2 and R3 are the same or different and represent a hydrogen atom or a lower alkyl group which may be substituted by a monocyclic cycloalkyl group, a polycyclic cycloalkyl group, or an aryl group.

摘要翻译： 本发明的目的是找到具有由通式[I]表示的结构的尿素化合物的新药理作用。 具有由通式[I]表示的结构的脲化合物或其盐对TRPV1介导的疾病具有优异的治疗作用。 在该式中，A表示低级亚烷基或低级亚烯基; R1表示氢原子，可以具有取代基的烷基或可具有取代基的烯基; R2和R3相同或不同，表示氢原子或可被单环环烷基，多环环烷基或芳基取代的低级烷基。

公开(公告)号：US5114232A

公开(公告)日：1992-05-19

申请号：US635023

申请日：1990-12-28

申请人： Fumio Tsuji ,  Osamu Yoshikawa

发明人： Fumio Tsuji ,  Osamu Yoshikawa

IPC分类号： G01J3/45 ,  G01J3/453

CPC分类号： G01J3/4535 ,  G01J3/453 ,  G01N2021/3595

摘要： There is disclosed an interference spectrophotometer which collects data while monitoring the position of a movable mirror by providing quadrature control to accurately perform coherent addition of data. The spectrophotometer includes a main interferometer, a control interferometer, a sliding controller controlling movement of the movable mirror, an A/D converter converting analog data obtained by the main interferometer into digital form, a register for holding data obtained by one scan of the movable mirror, a memory for accumulating data obtained by numerous scans of the movable mirror, an up/down counter receiving the output signals from two detectors included in the control interferometer, and a decision part. When the counter's value varies, the counter causes the A/D converter to perform its A/D conversion. Then, the decision part checks the counter's value after the A/D conversion. If this value differs from the count value obtained prior to the A/D conversion, the data held in the register is discarded.

公开(公告)号：US4586190A

公开(公告)日：1986-04-29

申请号：US551609

申请日：1983-11-14

申请人： Fumio Tsuji

发明人： Fumio Tsuji

IPC分类号： A61B5/145 ,  G01N15/14 ,  G01N33/48 ,  G01N33/49 ,  G01N21/47

CPC分类号： G01N15/1459 ,  G01N33/48 ,  G01N2015/0073

摘要： A blood counter comprising a sheathed flow cell; a light source including what has the wavelengths causing absorption of light by hemoglobin in the blood; means for receiving transmitted light; means for receiving the scattered light; a decision assembly for judging, based on the output signals detected by means for receiving the transmitted light and scattered light, (i) the flowing cells therein to be a red blood cell if the degree of absorption is larger than the preselected level and (ii) the other to be a blood platelet if the intensity of the scattered light is larger than a certain level and if the degree of absorption is smaller than said preselected level; and a counter assembly for counting out the red blood cells and blood platelets.

摘要翻译： 一种包含护套流动池的血液计数器; 包括具有引起血液中血红蛋白吸收光的波长的光源; 用于接收传输光的装置; 用于接收散射光的装置; 用于基于由接收透射光和散射光的装置检测到的输出信号，（i）如果吸收度大于预选水平，则其中的流动细胞为红细胞， ）如果散射光的强度大于一定水平，并且如果吸收度小于所述预选水平，则另一个为血小板; 以及用于计数红细胞和血小板的计数器组件。