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27 条记录 (耗时 0.022 秒)

    Cycloalkyl hydroxyureas
    3.
    发明授权
    Cycloalkyl hydroxyureas 失效
    环烷基羟基脲

    公开(公告)号：US5681858A

    公开(公告)日：1997-10-28

    申请号：US525748

    申请日：1995-10-03

    申请人： Rodney William Stevens ,  Takashi Mano ,  Yoshiyuki Okumura ,  Masami Nakane

    发明人： Rodney William Stevens ,  Takashi Mano ,  Yoshiyuki Okumura ,  Masami Nakane

    IPC分类号： A61K31/17 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07C273/08 ,  C07C273/18 ,  C07C275/64 ,  C07C323/47 ,  C07C273/02 ,  C07C275/24

    CPC分类号： C07C275/64 ,  C07C323/47 ,  C07C2101/04 ,  C07C2101/08

    摘要： The present invention provides a novel N-hydroxyurea compound of chemical formula (I) wherein R.sup.1 and R.sup.2 are each independently hydrogen or C.sub.1 -C.sub.4 alkyl; Ar is phenyl or mono-, di- or trisubstituted phenyl; A is a valence bond or a C.sub.1 -C.sub.6 alkylene chain, optionally having one double bond or one triple bond in the chain, and optionally having one or more C.sub.1 -C.sub.4 alkyl groups attached to the chain: X is oxygen or sulfur, n is an integer of 3 to 6; M is hydrogen, pharmaceutically acceptable cation or a metabolically cleavable group: and X and A may be attached at any available position on the ring. These compounds are useful for treatment or alleviation of inflammatory diseases, allergy and cardiovascular diseases in mammals and as the active ingredient in pharmaceutical compositions for treating such conditions.

    摘要翻译： PCT No.PCT / JP94 / 00567 Sec。 371 1995年10月3日第 102（e）日期1995年10月3日PCT 1994年4月5日PCT PCT。 第WO94 / 22814号公报 （I）本发明提供一种化学式（I）的新型N-羟基脲化合物，其中R 1和R 2各自独立地为氢或C 1 -C 4烷基; Ar是苯基或单，二或三取代的苯基; A是价键或C 1 -C 6亚烷基链，任选在链中具有一个双键或一个三键，并且任选地具有连接到链上的一个或多个C 1 -C 4烷基：X是氧或硫，n是 3〜6的整数; M是氢，药学上可接受的阳离子或代谢可切割基团：X和A可以连接在环上的任何可用位置。 这些化合物可用于治疗或缓解哺乳动物的炎性疾病，变态反应和心血管疾病，并用作用于治疗这些病症的药物组合物中的活性成分。

    FLUID EJECTING APPARATUS
    5.
    发明申请
    FLUID EJECTING APPARATUS 审中-公开
    流体喷射装置

    公开(公告)号：US20100045733A1

    公开(公告)日：2010-02-25

    申请号：US12543643

    申请日：2009-08-19

    申请人： Takashi Mano

    发明人： Takashi Mano

    IPC分类号： B41J2/165

    CPC分类号： B41J2/16523 ,  B41J2/16508 ,  B41J2/17596

    摘要： A fluid ejecting apparatus includes a fluid ejecting head with a nozzle forming face having formed thereon a plurality of nozzles for ejecting fluid, a cap that is able to form a sealed space together with the nozzle forming face by being in contact with the nozzle forming face, a decompressing unit that is coupled to the cap so as to decompress the sealed space via a first channel, an ambient air ventilating unit that is coupled to the cap so as to open the sealed space to ambient air via a second channel, and a check valve that is provided on the second channel between the cap and the ambient air ventilating unit.

    摘要翻译： 流体喷射装置包括具有喷嘴形成面的流体喷射头，喷嘴形成面上形成有用于喷射流体的多个喷嘴，能够通过与喷嘴形成面接触而与喷嘴形成面一起形成密封空间的盖 ，减压单元，其联接到所述盖以便经由第一通道对所述密封空间进行减压;环境空气通风单元，其联接到所述盖，以经由第二通道将所述密封空间打开到环境空气;以及 在盖和环境空气通风单元之间的第二通道上提供止回阀。

    PROCESS FOR PREPARING MODIFIED POLYISOCYANATE
    7.
    发明申请
    PROCESS FOR PREPARING MODIFIED POLYISOCYANATE 审中-公开
    制备改性聚异氰酸酯的方法

    公开(公告)号：US20100120992A1

    公开(公告)日：2010-05-13

    申请号：US12448003

    申请日：2007-11-24

    申请人： Nobuhiro Kamiyama ,  Tomoaki Fukuba ,  Takashi Mano

    发明人： Nobuhiro Kamiyama ,  Tomoaki Fukuba ,  Takashi Mano

    IPC分类号： C08L75/04 ,  C08G18/16

    CPC分类号： C08G18/797 ,  C07C267/00 ,  C08G18/025 ,  C08G18/10

    摘要： Purpose: A process for preparing a liquid organic isocyanate having a carbodiimide group and/or an uretonimine group, excellent in storage stability. Solution: In a process for preparing a modified polyisocyanate by carbodiimidizing an organic polyisocyanate in the presence of a phospholine-based catalyst, silicon dioxide particles having a specific surface area of at least 400 m2/g and an oil absorption of at least 180 ml/100 g are used to adsorb and inactivate the catalyst to thereby terminate the carbodiimidization reaction.

    摘要翻译： 目的：制备具有优异的储存稳定性的具有碳二亚胺基和/或脲酮亚胺基的液体有机异氰酸酯的方法。 溶液：在磷酸基类催化剂存在下，通过碳化有机多异氰酸酯的碳化二亚胺制备改性多异氰酸酯的方法，比表面积至少为400m 2 / g，吸油量至少为180ml / 100g用于吸附和灭活催化剂，从而终止碳二亚胺化反应。

    Imidazole lipoxygenase inhibitors
    8.
    发明授权
    Imidazole lipoxygenase inhibitors 失效
    咪唑脂氧合酶抑制剂

    公开(公告)号：US5753682A

    公开(公告)日：1998-05-19

    申请号：US553546

    申请日：1996-05-06

    申请人： Rodney W. Stevens ,  Takashi Mano ,  Kazuo Ando

    发明人： Rodney W. Stevens ,  Takashi Mano ,  Kazuo Ando

    IPC分类号： A61K31/415 ,  A61K31/4178 ,  A61P9/00 ,  A61P11/00 ,  A61P17/00 ,  A61P19/02 ,  A61P25/00 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07D233/54 ,  C07D233/60 ,  C07D305/04 ,  C07D309/02 ,  C07D405/10 ,  C07D405/12 ,  C07D405/14 ,  C07D521/00

    CPC分类号： C07D233/64 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D405/12 ,  C07D405/14

    摘要： Certain novel imidazole derivatives having the ability to inhibit the lipoxygenase enzyme and having formula (I), wherein Y is hydrogen, C.sub.1 -C.sub.8 alkyl, halosubstituted C.sub.1 -C.sub.4 alkyl, phenyl, substituted phenyl, C.sub.7 -C.sub.14 phenylalkyl, C.sub.7 -C.sub.14 (substituted phenyl)alkyl, pyridyl, substituted pyridyl, C.sub.6 -C.sub.13 pyridylalkyl or C.sub.6 -C.sub.13 (substituted pyridyl)alkyl, wherein each substituent is independently halo, nitro, cyano, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, halosubstituted C.sub.1 -C.sub.4 alkyl, halosubstituted C.sub.1 -C.sub.4 alkoxy, NR.sup.4 R.sup.5, CO.sub.2 R.sup.4 or CONR.sup.4 R.sup.5, wherein R.sup.4 and R.sup.5 are each, independently, hydrogen or C.sub.1 -C.sub.6 alkyl; Ar.sup.1 and Ar.sup.2 are each, independently, phenylene, mono-substituted phenylene or di-substituted phenylene, wherein the substituents are, independently, halo, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, halo-substituted C.sub.1 -C.sub.4 alkyl or halo-substituted C.sub.1 -C.sub.4 alkoxy; X and X.sup.1 are each, independently, O, S, SO or SO.sub.2 ; R' is hydrogen or C.sub.1 -C.sub.4 alkyl; and R.sup.2 and R.sup.3 are each, independently, methylene, ethylene or propylene. These compounds are useful for the treatment of disease states such as bronchial asthma, skin disorders and arthritis in mammals, and as the active ingredient in pharmaceutical compositions for treating such conditions.

    摘要翻译： PCT No.PCT / JP94 / 00836 Sec。 371日期：1996年5月6日 102（e）日期1996年5月6日PCT 1994年5月25日PCT公布。 第WO94 / 29299号公报 日期：1994年12月22日具有抑制脂氧合酶和具有式（I）的能力的新型咪唑衍生物，其中Y为氢，C1-C8烷基，卤代C1-C4烷基，苯基，取代苯基，C7-C14苯基烷基， C7-C14（取代苯基）烷基，吡啶基，取代的吡啶基，C6-C13吡啶基烷基或C6-C13（取代的吡啶基）烷基，其中各取代基独立地为卤素，硝基，氰基，C 1 -C 4烷基，C 1 -C 4烷氧基， C 1 -C 4烷基，卤代C 1 -C 4烷氧基，NR 4 R 5，CO 2 R 4或CONR 4 R 5，其中R 4和R 5各自独立地为氢或C 1 -C 6烷基; Ar 1和Ar 2各自独立地为亚苯基，单取代亚苯基或二取代亚苯基，其中取代基独立地为卤素，C 1 -C 4烷基，C 1 -C 4烷氧基，卤素取代的C 1 -C 4烷基或卤素取代的 C1-C4烷氧基; X和X1各自独立地为O，S，SO或SO 2; R'是氢或C 1 -C 4烷基; 并且R 2和R 3各自独立地为亚甲基，亚乙基或亚丙基。 这些化合物可用于治疗疾病状态，例如哺乳动物中的支气管哮喘，皮肤病和关节炎，以及用作治疗这些病症的药物组合物中的活性成分。

    Liquid ejecting apparatus
    9.
    发明授权
    Liquid ejecting apparatus 有权
    液体喷射装置

    公开(公告)号：US07641305B2

    公开(公告)日：2010-01-05

    申请号：US11808833

    申请日：2007-06-13

    申请人： Takashi Mano ,  Shozo Kuwada ,  Nobuhito Takahashi ,  Hitoshi Hayakawa

    发明人： Takashi Mano ,  Shozo Kuwada ,  Nobuhito Takahashi ,  Hitoshi Hayakawa

    IPC分类号： B41J2/165

    CPC分类号： B41J2/16508 ,  B41J2/16523 ,  B41J2002/1742

    摘要： A printer includes a cleaning mechanism that reliably performs an operation of cleaning a liquid ejecting head with a small amount of driving energy. The cleaning mechanism includes a cap manufactured by coinjection molding of a core part and an elastic part. The cap includes a bottom surface, an outer wall, and a partition wall dividing a cap inner space surrounded by the outer wall into two. A ratio of the elastic part in the partition wall is higher than that in the outer wall. With this structure, the partition wall is more elastically deformable than the outer wall. When the cap comes into contact with a nozzle surface of a recording head and covers nozzle rows, the outer wall comes into contact with the nozzle surface with a larger stress compared with the partition wall, and seals chambers where the nozzle rows on the nozzle surface are exposed.

    摘要翻译： 打印机包括清洁机构，其可靠地执行用少量驱动能量清洗液体喷射头的操作。 清洁机构包括通过芯部和弹性部的共注射成型制造的盖。 盖包括底面，外壁和将由外壁包围的盖内部空间分成两部分的隔壁。 分隔壁中的弹性部分的比例高于外壁中的弹性部分。 利用这种结构，分隔壁比外壁更可弹性变形。 当盖与记录头的喷嘴表面接触并且覆盖喷嘴列时，与分隔壁相比，外壁与喷嘴表面接触得更大，并且密封腔，喷嘴表面上的喷嘴列 被暴露。

    Liquid ejecting apparatus
    10.
    发明申请
    Liquid ejecting apparatus 有权
    液体喷射装置

    公开(公告)号：US20050104924A1

    公开(公告)日：2005-05-19

    申请号：US10953108

    申请日：2004-09-30

    申请人： Koji Harada ,  Takashi Mano ,  Shozo Kuwada ,  Nobuhito Takahashi ,  Hitoshi Hayakawa ,  Tsutomu Kobayashi

    发明人： Koji Harada ,  Takashi Mano ,  Shozo Kuwada ,  Nobuhito Takahashi ,  Hitoshi Hayakawa ,  Tsutomu Kobayashi

    IPC分类号： B41J2/165

    CPC分类号： B41J2/16508 ,  B41J2/16523 ,  B41J2002/1742

    摘要： A printer includes a cleaning mechanism that reliably performs an operation of cleaning a liquid ejecting head with a small amount of driving energy. The cleaning mechanism includes a cap manufactured by coinjection molding of a core part and an elastic part. The cap includes a bottom surface, an outer wall, and a partition wall dividing a cap inner space surrounded by the outer wall into two. A ratio of the elastic part in the partition wall is higher than that in the outer wall. With this structure, the partition wall is more elastically deformable than the outer wall. When the cap comes into contact with a nozzle surface of a recording head and covers nozzle rows, the outer wall comes into contact with the nozzle surface with a larger stress compared with the partition wall, and seals chambers where the nozzle rows on the nozzle surface are exposed.

    摘要翻译： 打印机包括清洁机构，其可靠地执行用少量驱动能量清洗液体喷射头的操作。 清洁机构包括通过芯部和弹性部的共注射成型制造的盖。 盖包括底面，外壁和将由外壁包围的盖内部空间分成两部分的隔壁。 分隔壁中的弹性部分的比例高于外壁中的弹性部分。 利用这种结构，分隔壁比外壁更可弹性变形。 当盖与记录头的喷嘴表面接触并且覆盖喷嘴列时，与分隔壁相比，外壁与喷嘴表面接触得更大，并且密封腔，喷嘴表面上的喷嘴列 被暴露。