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公开(公告)号：US20060235078A1
公开(公告)日：2006-10-19
申请号：US11455813
申请日：2006-06-20
申请人： Futoshi Matsuyama , Yutaka Seino , Mitsuo Fukushima , Toshihiro Miura , Takeshi Fujita , Tetsuo Kaneko
发明人： Futoshi Matsuyama , Yutaka Seino , Mitsuo Fukushima , Toshihiro Miura , Takeshi Fujita , Tetsuo Kaneko
IPC分类号： A61K31/20
CPC分类号： A61K31/215 , A23K20/105 , A23V2002/00 , A61K31/19 , A61K31/704 , A23V2200/328
摘要： The present invention provides early insulin secretion stimulators consisting of triterpenes represented by the following general formula (1) and/or triterpenes represented by the following general formula (2). [where R1 represents COOH, etc., R11 and R12 represent CH2OH, etc., X1 represents hydrogen or OH and X11, X12, X21 and X22 represent OH, etc.]
摘要翻译： 本发明提供了由以下通式（1）表示的三萜烯和/或由以下通式（2）表示的三萜烯组成的早期胰岛素分泌刺激剂。 [其中R 1表示COOH等，R 11和R 12表示CH 2 OH等。 X 1表示氢或OH，X 11，X 12，X 21和X 22 代表OH等]
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公开(公告)号：US20070093552A1
公开(公告)日：2007-04-26
申请号：US10572460
申请日：2004-09-22
申请人： Futoshi Matsuyama , Yutaka Seino , Mitsuo Fukushima , Toshihiro Miura , Takeshi Fujita , Tetsuo Kaneko
发明人： Futoshi Matsuyama , Yutaka Seino , Mitsuo Fukushima , Toshihiro Miura , Takeshi Fujita , Tetsuo Kaneko
CPC分类号： A61K31/20 , C07J63/008
摘要： The invention provides an early insulin secretion stimulator consisting of corosolic acid, etc. The early insulin secretion stimulator of the invention is capable of rapidly inducing secretion of insulin immediately after meals without inducing secretion of excess insulin in the absence of blood glucose increase.
摘要翻译： 本发明提供了由科罗索酸等组成的早期胰岛素分泌刺激剂。本发明的早期胰岛素分泌刺激剂能够在饭后立即迅速诱导胰岛素分泌，而不会在没有血糖升高的情况下诱导分泌过量的胰岛素。
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公开(公告)号：US20050143464A1
公开(公告)日：2005-06-30
申请号：US10945438
申请日：2004-09-21
申请人： Futoshi Matsuyama , Yutaka Seino , Mitsuo Fukushima , Toshihiro Miura , Takeshi Fujita , Tetsuo Kaneko
发明人： Futoshi Matsuyama , Yutaka Seino , Mitsuo Fukushima , Toshihiro Miura , Takeshi Fujita , Tetsuo Kaneko
IPC分类号： A23K1/16 , A61K31/19 , A61K31/20 , A61K31/215 , A61K31/704 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/50 , A61P9/12 , C07C61/28
CPC分类号： A61K31/215 , A23K20/105 , A23V2002/00 , A61K31/19 , A61K31/704 , A23V2200/328
摘要： The present invention provides early insulin secretion stimulators consisting of triterpenes represented by the following general formula (1) and/or triterpenes represented by the following general formula (2). [where R1 represents COOH, etc., R11 and R12 represent CH2OH, etc., X1 represents hydrogen or OH and X11, X12, X21 and X22 represent OH, etc.]
摘要翻译： 本发明提供了由以下通式（1）表示的三萜烯和/或由以下通式（2）表示的三萜烯组成的早期胰岛素分泌刺激剂。 [其中R 1表示COOH等，R 11和R 12表示CH 2 OH等。 X 1表示氢或OH，X 11，X 12，X 21和X 22 代表OH等]
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公开(公告)号：US20050267055A1
公开(公告)日：2005-12-01
申请号：US11020571
申请日：2004-12-27
IPC分类号： A61K31/203 , A61K31/704
CPC分类号： A61K31/203 , A61K31/704
摘要： The present invention provides a glucose tolerance improving agent containing as an active ingredient at least one triterpene selected from the group consisting of corosolic acid, an analogous compound of corosolic acid, and a pharmaceutically acceptable salt thereof.
摘要翻译： 本发明提供含有选自科罗索酸，科罗索酸类似化合物及其药学上可接受的盐的至少一种三萜烯作为活性成分的葡萄糖耐量提高剂。
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公开(公告)号：US20050137259A1
公开(公告)日：2005-06-23
申请号：US10945433
申请日：2004-09-21
申请人： Futoshi Matsuyama , Yutaka Seino , Mitsuo Fukushima , Toshihiro Miura , Takeshi Fujita , Tetsuo Kaneko
发明人： Futoshi Matsuyama , Yutaka Seino , Mitsuo Fukushima , Toshihiro Miura , Takeshi Fujita , Tetsuo Kaneko
IPC分类号： A61K31/202
CPC分类号： A23G3/36 , A21D2/145 , A21D13/32 , A21D13/38 , A23C2240/15 , A23L2/52 , A23L33/10 , A23L33/105 , A23L33/30 , A61K31/191 , A61K31/215
摘要： The invention provides an early insulin secretion stimulator comprising corosolic acid, etc. The early insulin secretion stimulator of the invention is capable of rapidly inducing secretion of insulin immediately after meals without inducing secretion of insulin in the absence of blood glucose increase.
摘要翻译： 本发明提供了包含科罗索酸等的早期胰岛素分泌刺激剂。本发明的早期胰岛素分泌刺激剂能够在饭后立即迅速诱导胰岛素分泌，而不会在没有血糖升高的情况下诱导胰岛素分泌。
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6.发明授权Cloning of DNA encoding human motilin precursor and expression of the precursor 失效克隆编码人类胃动素前体的DNA和前体的表达
公开(公告)号：US4985356A
公开(公告)日：1991-01-15
申请号：US190849
申请日：1988-05-06
申请人： Kiichi Sawai , Jun Takeda , Yutaka Seino , Hiroo Imura , Kenichi Tanaka , Haruo Takahashi , Takahiko Mitani , Masayasu Kurono
发明人： Kiichi Sawai , Jun Takeda , Yutaka Seino , Hiroo Imura , Kenichi Tanaka , Haruo Takahashi , Takahiko Mitani , Masayasu Kurono
CPC分类号： C07K14/63
摘要： A cloned single-strand DNA comprising nucleotide sequence which encodes human motilin precursor, a cloned double-strand DNA consisting of the single-strand DNA and its complementary single-strand DNA, a fragment of the single- or double-strand DNA, a plasmid, in which the double-strand DNA or its fragment is integrated, as well as a process for the preparation of the single- or double-strand DNA.
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公开(公告)号：US07745689B2
公开(公告)日：2010-06-29
申请号：US10545276
申请日：2004-02-13
申请人： Akari Inada , Atsushi Fukatsu , Yutaka Seino
发明人： Akari Inada , Atsushi Fukatsu , Yutaka Seino
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , C07K14/4703
摘要： A nephropathy-associated gene which encodes a transcription repressor; and a nonhuman transgenic animal suffering from nephropathy which is constructed by transferring the above gene and allows the observation of increases in urinary volume, urinary albumin and urinary NAG, pyelectasis, enlargement in kidney tubule and glomerular swelling at the early stage and the following sclerosis.
摘要翻译： 编码转录阻遏物的肾病相关基因; 和通过转移上述基因构建的非人类转基因动物，并且允许观察尿液体积增加，尿白蛋白和尿NAG，早期阶段的肾小管和肾小球肿胀的扩大以及随后的硬化。
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公开(公告)号：US20060140945A1
公开(公告)日：2006-06-29
申请号：US10545276
申请日：2004-02-13
申请人： Akari Inada , Atsushi Fukatsu , Yutaka Seino
发明人： Akari Inada , Atsushi Fukatsu , Yutaka Seino
IPC分类号： A01K67/033 , C12Q1/68 , C12P21/06 , A61K39/395 , C07K14/47 , C07K16/18
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , C07K14/4703
摘要： A nephropathy-associated gene which encodes a transcription repressor; and a nonhuman transgenic animal suffering from nephropathy which is constructed by transferring the above gene and allows the observation of increases in urinary volume, urinary albumin and urinary NAG, pyelectasis, enlargement in kidney tubule and glomerular swelling at the early stage and the following sclerosis.
摘要翻译： 编码转录阻遏物的肾病相关基因; 和通过转移上述基因构建的非人类转基因动物，并且允许观察尿液体积增加，尿白蛋白和尿NAG，早期阶段的肾小管和肾小球肿胀的扩大以及随后的硬化。
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