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公开(公告)号:US08815935B2
公开(公告)日:2014-08-26
申请号:US13614789
申请日:2012-09-13
申请人: Ohyun Kwon , Fuyuhiko Tamanoi , Hannah Fiji , Masaru Watanabe
发明人: Ohyun Kwon , Fuyuhiko Tamanoi , Hannah Fiji , Masaru Watanabe
IPC分类号: C07D207/48 , A61K31/40 , C07D207/20 , C07D211/96
CPC分类号: C07D211/96 , C07D207/20 , C07D207/48
摘要: The present invention is directed to novel compounds. These compounds can be useful in inhibiting the activity of protein prenyltransferases including GGTase I and/or RabGGTase. The compounds can also be used as anti-cancer therapeutics including as part of methods for treating cancer, in assays, and in kits.
摘要翻译: 本发明涉及新化合物。 这些化合物可用于抑制蛋白异戊烯基转移酶(包括GGTase I和/或RabGGTase)的活性。 这些化合物也可以用作抗癌治疗剂,包括作为治疗癌症的方法的一部分,在测定和试剂盒中。
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公开(公告)号:US08093274B2
公开(公告)日:2012-01-10
申请号:US12293993
申请日:2007-03-22
申请人: Fuyuhiko Tamanoi , Ohyun Kwon , Masaru Watanabe , Hannah Fiji
发明人: Fuyuhiko Tamanoi , Ohyun Kwon , Masaru Watanabe , Hannah Fiji
IPC分类号: A61K31/44 , A61K31/40 , A61P35/00 , A61P35/02 , C07D211/78 , C07D207/48
CPC分类号: C07D207/48 , C07D211/96
摘要: The present invention is directed to novel compounds. These compounds can be useful in inhibiting the activity of GGTase I. The compounds can also be used as anti-cancer therapeutics including as part of methods for treating cancer, in assays, and in kits.
摘要翻译: 本发明涉及新化合物。 这些化合物可用于抑制GGT酶I的活性。该化合物也可用作抗癌治疗剂,包括作为治疗癌症的方法的一部分,在测定和试剂盒中。
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公开(公告)号:US20130102639A1
公开(公告)日:2013-04-25
申请号:US13614789
申请日:2012-09-13
申请人: Ohyun Kwon , Fuyuhiko Tamanoi , Hannah Fiji , Masaru Watanabe
发明人: Ohyun Kwon , Fuyuhiko Tamanoi , Hannah Fiji , Masaru Watanabe
IPC分类号: C07D211/96 , C07D207/48
CPC分类号: C07D211/96 , C07D207/20 , C07D207/48
摘要: The present invention is directed to novel compounds. These compounds can be useful in inhibiting the activity of protein prenyltransferases including GGTase I and/or RabGGTase. The compounds can also be used as anti-cancer therapeutics including as part of methods for treating cancer, in assays, and in kits.
摘要翻译: 本发明涉及新化合物。 这些化合物可用于抑制蛋白异戊烯基转移酶(包括GGTase I和/或RabGGTase)的活性。 这些化合物也可以用作抗癌治疗剂,包括作为治疗癌症的方法的一部分,在测定中和试剂盒中。
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公开(公告)号:US20100063114A1
公开(公告)日:2010-03-11
申请号:US12293993
申请日:2007-03-22
申请人: Fuyuhiko Tamanoi , Ohyun Kwon , Masaru Watanabe , Hannah Fiji
发明人: Fuyuhiko Tamanoi , Ohyun Kwon , Masaru Watanabe , Hannah Fiji
IPC分类号: A61K31/44 , C07D211/78 , C07D207/22 , C07D207/48 , A61K31/40 , A61P35/00 , A61P35/02
CPC分类号: C07D207/48 , C07D211/96
摘要: The present invention is directed to novel compounds. These compounds can be useful in inhibiting the activity of GGTase I. The compounds can also be used as anti-cancer therapeutics including as part of methods for treating cancer, in assays, and in kits.
摘要翻译: 本发明涉及新化合物。 这些化合物可用于抑制GGT酶I的活性。该化合物也可用作抗癌治疗剂,包括作为治疗癌症的方法的一部分,在测定和试剂盒中。
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公开(公告)号:US20110178138A1
公开(公告)日:2011-07-21
申请号:US13056077
申请日:2008-07-28
申请人: Ohyun Kwon , Fuyuhiko Tamanoi , Hanna Fiji , Masaru Watanabe
发明人: Ohyun Kwon , Fuyuhiko Tamanoi , Hanna Fiji , Masaru Watanabe
IPC分类号: A61K31/4418 , C07D207/48 , C07D211/96 , A61K31/40 , C12N5/071 , C12Q1/48
CPC分类号: C07D211/96 , C07D207/20 , C07D207/48
摘要: The present invention is directed to novel compounds. These compounds can be useful in inhibiting the activity of protein prenyltransferases including GGTase I and/or RabGGTase. The compounds can also be used as anti-cancer therapeutics including as part of methods for treating cancer, in assays, and in kits.
摘要翻译: 本发明涉及新化合物。 这些化合物可用于抑制蛋白异戊烯基转移酶(包括GGTase I和/或RabGGTase)的活性。 这些化合物也可以用作抗癌治疗剂,包括作为治疗癌症的方法的一部分,在测定和试剂盒中。
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公开(公告)号:US07918463B2
公开(公告)日:2011-04-05
申请号:US12230708
申请日:2008-09-03
申请人: Hidenori Arai , Kazuki Takeno , Ichiro Yamane , Shinobu Munekata , Katsumi Yamashina , Masaru Watanabe
发明人: Hidenori Arai , Kazuki Takeno , Ichiro Yamane , Shinobu Munekata , Katsumi Yamashina , Masaru Watanabe
IPC分类号: F16J15/32
CPC分类号: F16F9/36 , F16J15/3232 , F16J15/3236 , F16J15/56
摘要: A reciprocating seal used, for example, for a shock absorber. A main seal lip has a two-step lip structure including a first lip and a second lip and a plurality of protrusions extending in the direction of the shaft are formed on a sliding contact surface of the second lip, thereby improving frictional force characteristics and, at the same time, improving sealing performance.
摘要翻译: 用于例如用于减震器的往复式密封件。 主密封唇具有包括第一唇缘和第二唇缘的两段唇缘结构,并且在第二唇缘的滑动接触表面上形成有在轴的方向上延伸的多个突起,从而提高摩擦力特性, 同时提高密封性能。
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公开(公告)号:US20090134586A1
公开(公告)日:2009-05-28
申请号:US12230708
申请日:2008-09-03
申请人: Hidenori Arai , Kazuki Takeno , Ichiro Yamane , Shinobu Munekata , Katsumi Yamashina , Masaru Watanabe
发明人: Hidenori Arai , Kazuki Takeno , Ichiro Yamane , Shinobu Munekata , Katsumi Yamashina , Masaru Watanabe
IPC分类号: F16J15/32
CPC分类号: F16F9/36 , F16J15/3232 , F16J15/3236 , F16J15/56
摘要: The present invention relates to a reciprocating seal used, for example, for a shock absorber. A main seal lip 32 has a two-step lip structure including a first lip 32a and a second lip 32b and a plurality of protrusions 34 extending in the direction of the shaft are formed on a sliding contact surface of the second lip 32b, thereby improving frictional force characteristics and, at the same time, improving sealing performance.
摘要翻译: 本发明涉及例如用于减震器的往复式密封件。 主密封唇32具有包括第一唇缘32a和第二唇缘32b的两阶唇缘结构,并且在第二唇缘32b的滑动接触表面上形成有沿轴向方向延伸的多个突起34,从而改善 摩擦力特性,同时提高密封性能。
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公开(公告)号:US20070241515A1
公开(公告)日:2007-10-18
申请号:US11661571
申请日:2005-08-03
申请人: Hiroyuki Sato , Masaru Watanabe , Koichi Mizunoya , Takeo Otani , Hidenori Arai , Sosuke Ito , Ryota Okubo
发明人: Hiroyuki Sato , Masaru Watanabe , Koichi Mizunoya , Takeo Otani , Hidenori Arai , Sosuke Ito , Ryota Okubo
IPC分类号: F16J15/32
CPC分类号: F16F9/36 , F16C33/7823 , F16C2240/54 , F16J15/3232 , F16J15/324
摘要: In a sealing device (1) , in which a main seal lip (6) used for a shock absorber is formed in a one-stage seal lip structure, for the purpose to improve friction characteristics while securing sealing performance, a roughened portion (63) to which satin finishing is applied to form projections and recessions on the surface thereof is formed on the sliding surface (61) of the main seal lip (6) slidably moving on a contacting member at a position apart a specified distance from a lip edge (62). An area between the lip edge (62) and the portion where the roughened portion (63) is formed is a plane portion (64) to which the satin finishing for forming irregularities is not applied. In place of the satin finishing, a plurality of axially extending projections (65), concave threads (67), or lattice-shaped projections (68) may be formed on the roughened portion.
摘要翻译: 在用于减震器的主密封唇(6)形成在一级密封唇结构中的密封装置(1)中,为了在确保密封性能的同时改善摩擦特性,将粗糙部分(63) ),在主密封唇缘(6)的滑动表面(61)上形成用于在其表面上形成凸起和凹陷的缎纹整理,其在接触构件上在与唇缘 (62)。 唇边缘(62)与粗糙部(63)形成部分之间的区域是不施加用于形成凹凸的缎纹整理的平面部分(64)。 代替缎纹整理,可以在粗糙部分上形成多个轴向延伸的突起(65),凹入的线(67)或格子状的突起(68)。
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公开(公告)号:US20060268405A1
公开(公告)日:2006-11-30
申请号:US10558924
申请日:2004-06-23
CPC分类号: G02B6/2746 , G02F1/093
摘要: In conventional optical isolators, an optical signal is dispersed by polarization or the characteristics are varied by heat generation in a garnet crystal. According to the invention, the crystal optical axis (3c) of rutile crystal (3) is oriented so that the separation directions of the ordinary ray (O) and the extraordinary ray (E) are perpendicular to the plane including the optical axes of optical fibers (10, 11). Furthermore, the focusing central optical axis (6c) of a focusing rod lens (6) is arranged parallel with optical axes of the optical fibers (10, 11) and at a substantially equal distance from the four rays, i.e. the ordinary ray (O) and the extraordinary ray (E) propagating along the optical axis of the optical fiber (10) and the ordinary ray (O) and the extraordinary ray (E) propagating along the optical axis of the optical fiber (11). An air gap (7) of about 200 [μm] is provided, as a heat insulating means, between the focusing rod lens (6) and a magnetized garnet crystal (8).
摘要翻译: 在传统的光隔离器中,通过极化分散光信号,或者通过石榴石晶体中的发热来改变特性。 根据本发明,金红石晶体(3)的晶体光轴(3c)被定向成使得普通光线(O)和非寻常光线(E)的分离方向垂直于包括光轴 光纤(10,11)。 此外,聚焦棒透镜(6)的聚焦中心光轴(6c)与光纤(10,11)的光轴平行并且与四条光线基本相等的距离(即普通光线 O)和沿着光纤(10)的光轴传播的异常射线(E)和沿光纤(11)的光轴传播的普通射线(O)和异常射线(E)。 在聚焦棒透镜(6)和被磁化的石榴石晶体(8)之间提供约200μm的气隙(7)作为隔热装置。
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公开(公告)号:US20060204267A1
公开(公告)日:2006-09-14
申请号:US11335850
申请日:2006-01-19
申请人: Masaru Watanabe
发明人: Masaru Watanabe
IPC分类号: G03G15/00
CPC分类号: G03G15/5058 , G03G2215/00042
摘要: A toner density on a toner image carrier means such as an intermediate transfer belt is accurately measured, even if a durability of the toner image carrier means is changed. It is assumed that output dark voltages from said first and second photo-detector means are P0 and S0, respectively; back-ground voltages from said first and second photo-detector means are Pg and Sg, respectively, when any toner is not attached on said toner image carrier means; measured voltages from said first and second photo-detector means are P and S, respectively, when said toner image was formed on said toner image carrier means. Then, a coverage rate CR and a durability X are calculated by the following formulae. CR=1−((P−P0)−(S−S0))/((Pg−P0)−(Sg−S0)), X=A×(1−(Sg−S0)/((Pg−P0)). Further, the toner density is obtained on the basis of the corrected CR by using durability X as a parameter.
摘要翻译: 即使改变调色剂图像承载装置的耐久性,也可以精确地测量诸如中间转印带之类的调色剂图像载体装置上的调色剂浓度。 假设来自所述第一和第二光电检测器装置的输出暗电压分别为P0和S0; 当任何调色剂未附着在所述调色剂图像载体装置上时,来自所述第一和第二光检测器装置的背景电压分别为Pg和Sg; 当所述调色剂图像形成在所述调色剂图像载体装置上时,来自所述第一和第二光检测器装置的测量电压分别为P和S。 然后,通过以下公式计算覆盖率CR和耐久性X. CR = 1 - ((P-P0) - (S-S0))/((Pg-P0) - (Sg- S0)),<?in-line-formula description =“In-line Formulas”end =“tail”?> <?in-line-formula description =“In-line Formulas”end =“lead”?> X = Ax(1-(Sg-S0)/((Pg-P0))。<?in-line-formula description =“In-line Formulas”end =“tail”?>此外,调色剂浓度基于 通过使用耐久性X作为参数来校正CR。
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