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    Anti-tissue factor antibodies and compositions
    1.
    发明申请
    Anti-tissue factor antibodies and compositions 有权
    抗组织因子抗体和组合物

    公开(公告)号：US20050220793A1

    公开(公告)日：2005-10-06

    申请号：US11010797

    申请日：2004-12-13

    申请人： G. Anderson ,  Bernard Scallon ,  Michael Naso ,  Ann Cai ,  Cam Ngo

    发明人： G. Anderson ,  Bernard Scallon ,  Michael Naso ,  Ann Cai ,  Cam Ngo

    IPC分类号： A61K39/395 ,  C07K16/22

    CPC分类号： C07K16/36 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76

    摘要： Isolated anti-tissue factor antibodies, immunoglobulins, cleavage products and other specified portions and variants thereof having enhanced ADCC activity, as well as anti-tissue factor antibody compositions, encoding or complementary nucleic acids, vectors, host cells, compositions, formulations, devices, transgenic animals, transgenic plants, and methods of making and using thereof. The antibodies of the invention bind human tissue factor and demonstrate enhanced ADCC activity. Accordingly, the antibodies can be used in a variety of methods for diagnosing, treating, and/or preventing diseases involving tissue factor, where enhanced ADCC activity is desirable such as cancer.

    摘要翻译： 分离的抗组织因子抗体，免疫球蛋白，切割产物和其具有增强的ADCC活性的其它指定部分和变体，以及抗组织因子抗体组合物，编码或互补核酸，载体，宿主细胞，组合物，制剂，装置， 转基因动物，转基因植物及其制备和使用方法。 本发明的抗体结合人组织因子并表现出增强的ADCC活性。 因此，抗体可用于各种诊断，治疗和/或预防涉及组织因子的疾病的方法，其中期望增加ADCC活性，例如癌症。

    High performance coated material with improved metal dusting corrosion resistance
    3.
    发明申请
    High performance coated material with improved metal dusting corrosion resistance 有权
    高性能涂层材料具有改善的金属除尘耐腐蚀性

    公开(公告)号：US20080020216A1

    公开(公告)日：2008-01-24

    申请号：US11827013

    申请日：2007-07-10

    申请人： Kenneth Bagnoli ,  G. Anderson ,  Trikur Ramanarayanan ,  ChangMin Chun

    发明人： Kenneth Bagnoli ,  G. Anderson ,  Trikur Ramanarayanan ,  ChangMin Chun

    IPC分类号： B32B15/04 ,  C23C16/00 ,  C23C4/06

    CPC分类号： C23C8/16 ,  C23C4/073 ,  C23C4/18 ,  Y10T428/1259 ,  Y10T428/12618 ,  Y10T428/12944 ,  Y10T428/24967 ,  Y10T428/26 ,  Y10T428/263 ,  Y10T428/265

    摘要： High performance coated metal compositions resistant to metal dusting corrosion and methods of providing such compositions are provided by the present invention. The coated metal compositions are represented by the structure (PQR), wherein P is an oxide layer at the surface of (PQR), Q is a coating metal layer interposed between P and R, and R is a base metal. P includes alumina, chromia, silica, mullite or mixtures thereof. Q includes Ni and Al, and at least one element selected from the group consisting of Cr, Si, Mn, Fe, Co, B, C, N, P, Ga, Ge, As, In, Sn, Sb, Pb, Sc, La, Y, Ce, Ti, Zr, Hf, V, Nb, Ta, Mo, W, Ru, Rh, Ir, Pd, Pt, Cu, Ag, Au and mixtures thereof. R is selected from the group consisting of carbon steels, low chromium steels, ferritic stainless steels, austenetic stainless steels, duplex stainless steels, Inconel alloys, Incoloy alloys, Fe—Ni based alloys, Ni-based alloys and Co-based alloys. Advantages exhibited by the disclosed coated metal compositions include improved metal dusting corrosion resistance at high temperatures in carbon-supersaturated environments having relatively low oxygen partial pressures. The coated metal compositions are suitable for use in syngas generation process equipment.

    摘要翻译： 通过本发明提供了耐金属粉尘腐蚀的高性能涂覆金属组合物和提供这种组合物的方法。 涂覆的金属组合物由结构（PQR）表示，其中P是（PQR）表面处的氧化物层，Q是介于P和R之间的涂层金属层，R是贱金属。 P包括氧化铝，氧化铬，二氧化硅，莫来石或其混合物。 Q包括Ni和Al，以及选自Cr，Si，Mn，Fe，Co，B，C，N，P，Ga，Ge，As，In，Sn，Sb，Pb，Sc中的至少一种元素 ，La，Y，Ce，Ti，Zr，Hf，V，Nb，Ta，Mo，W，Ru，Rh，Ir，Pd，Pt，Cu，Ag，Au及其混合物。 R选自碳钢，低铬钢，铁素体不锈钢，奥氏体不锈钢，双相不锈钢，Inconel合金，Incoloy合金，Fe-Ni基合金，Ni基合金和Co基合金。 所公开的涂覆的金属组合物显示的优点包括在具有相对低的氧分压的碳过饱和环境中在高温下提高的金属粉尘耐腐蚀性。 涂覆的金属组合物适用于合成气生成工艺设备。