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29 条记录 (耗时 0.031 秒)

    Anti-tissue factor antibodies and compositions
    1.
    发明申请
    Anti-tissue factor antibodies and compositions 有权
    抗组织因子抗体和组合物

    公开(公告)号：US20050220793A1

    公开(公告)日：2005-10-06

    申请号：US11010797

    申请日：2004-12-13

    申请人： G. Anderson ,  Bernard Scallon ,  Michael Naso ,  Ann Cai ,  Cam Ngo

    发明人： G. Anderson ,  Bernard Scallon ,  Michael Naso ,  Ann Cai ,  Cam Ngo

    IPC分类号： A61K39/395 ,  C07K16/22

    CPC分类号： C07K16/36 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76

    摘要： Isolated anti-tissue factor antibodies, immunoglobulins, cleavage products and other specified portions and variants thereof having enhanced ADCC activity, as well as anti-tissue factor antibody compositions, encoding or complementary nucleic acids, vectors, host cells, compositions, formulations, devices, transgenic animals, transgenic plants, and methods of making and using thereof. The antibodies of the invention bind human tissue factor and demonstrate enhanced ADCC activity. Accordingly, the antibodies can be used in a variety of methods for diagnosing, treating, and/or preventing diseases involving tissue factor, where enhanced ADCC activity is desirable such as cancer.

    摘要翻译： 分离的抗组织因子抗体，免疫球蛋白，切割产物和其具有增强的ADCC活性的其它指定部分和变体，以及抗组织因子抗体组合物，编码或互补核酸，载体，宿主细胞，组合物，制剂，装置， 转基因动物，转基因植物及其制备和使用方法。 本发明的抗体结合人组织因子并表现出增强的ADCC活性。 因此，抗体可用于各种诊断，治疗和/或预防涉及组织因子的疾病的方法，其中期望增加ADCC活性，例如癌症。

    Anti-tissue factor antibodies and compositions
    3.
    发明授权
    Anti-tissue factor antibodies and compositions 有权
    抗组织因子抗体和组合物

    公开(公告)号：US08293882B2

    公开(公告)日：2012-10-23

    申请号：US12412957

    申请日：2009-03-27

    申请人： G. Mark Anderson ,  Bernard Scallon ,  Michael Naso ,  Ann Cai ,  Cam Ngo

    发明人： G. Mark Anderson ,  Bernard Scallon ,  Michael Naso ,  Ann Cai ,  Cam Ngo

    IPC分类号： C07H21/04

    CPC分类号： C07K16/36 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76

    摘要： Isolated anti-tissue factor antibodies, immunoglobulins, cleavage products and other specified portions and variants thereof having enhanced ADCC activity, as well as anti-tissue factor antibody compositions, encoding or complementary nucleic acids, vectors, host cells, compositions, formulations, devices, transgenic animals, transgenic plants, and methods of making and using thereof. The antibodies of the invention bind human tissue factor and demonstrate enhanced ADCC activity. Accordingly, the antibodies can be used in a variety of methods for diagnosing, treating, and/or preventing diseases involving tissue factor, where enhanced ADCC activity is desirable such as cancer.

    摘要翻译： 分离的抗组织因子抗体，免疫球蛋白，切割产物和其具有增强的ADCC活性的其它指定部分和变体，以及抗组织因子抗体组合物，编码或互补核酸，载体，宿主细胞，组合物，制剂，装置， 转基因动物，转基因植物及其制备和使用方法。 本发明的抗体结合人组织因子并表现出增强的ADCC活性。 因此，抗体可用于各种诊断，治疗和/或预防涉及组织因子的疾病的方法，其中期望增加ADCC活性，例如癌症。

    Anti-tissue factor antibodies and compositions
    5.
    发明授权
    Anti-tissue factor antibodies and compositions 有权
    抗组织因子抗体和组合物

    公开(公告)号：US07605235B2

    公开(公告)日：2009-10-20

    申请号：US11010797

    申请日：2004-12-13

    申请人： G. Mark Anderson ,  Bernard Scallon ,  Michael Naso ,  Ann Cai ,  Cam Ngo

    发明人： G. Mark Anderson ,  Bernard Scallon ,  Michael Naso ,  Ann Cai ,  Cam Ngo

    IPC分类号： C12P21/08

    CPC分类号： C07K16/36 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76

    摘要： Isolated anti-tissue factor antibodies, immunoglobulins, cleavage products and other specified portions and variants thereof having enhanced ADCC activity, as well as anti-tissue factor antibody compositions, encoding or complementary nucleic acids, vectors, host cells, compositions, formulations, devices, transgenic animals, transgenic plants, and methods of making and using thereof. The antibodies of the invention bind human tissue factor and demonstrate enhanced ADCC activity. Accordingly, the antibodies can be used in a variety of methods for diagnosing, treating, and/or preventing diseases involving tissue factor, where enhanced ADCC activity is desirable such as cancer.

    摘要翻译： 分离的抗组织因子抗体，免疫球蛋白，切割产物和其具有增强的ADCC活性的其它指定部分和变体，以及抗组织因子抗体组合物，编码或互补核酸，载体，宿主细胞，组合物，制剂，装置， 转基因动物，转基因植物及其制备和使用方法。 本发明的抗体结合人组织因子并表现出增强的ADCC活性。 因此，抗体可用于各种诊断，治疗和/或预防涉及组织因子的疾病的方法，其中期望增加ADCC活性，例如癌症。

    Methods and vectors for generating asialylated immunoglobulins
    7.
    发明授权
    Methods and vectors for generating asialylated immunoglobulins 有权
    用于产生无唾液酸化免疫球蛋白的方法和载体

    公开(公告)号：US08540992B2

    公开(公告)日：2013-09-24

    申请号：US12521417

    申请日：2007-12-26

    申请人： Michael Naso ,  T. Shantha Raju ,  Bernard Scallon

    发明人： Michael Naso ,  T. Shantha Raju ,  Bernard Scallon

    IPC分类号： A61K39/395 ,  C12N9/00 ,  C12N1/20 ,  C12N15/00

    CPC分类号： C12N9/2402 ,  C07K16/00 ,  C07K16/241 ,  C07K2317/41 ,  C07K2317/72 ,  C07K2317/732 ,  C12N15/85 ,  C12P21/005 ,  C12Y302/01018

    摘要： The properties of an Fc-containing protein, for example, an antibody, are controlled by altering the sialylation of the oligosaccharides in the Fc region by transfecting the cell line expressing the Fc-containing protein with a vector sequence encoding a sialidase. The modified Fc-containing proteins have therapeutic utility in diseases or conditions in which it is desirable to control the affinity for one or more of the FcγRI, FcγRIIA, and FcγRIIIA receptors, ADCC activity, macrophage or monocyte activation, serum half-life, and avidity.

    摘要翻译： 通过用编码唾液酸酶的载体序列转染表达含Fc的蛋白质的细胞系，通过改变Fc区中寡糖的唾液酸化来控制含Fc的蛋白质，例如抗体的性质。 经修饰的含Fc蛋白质具有治疗效用，其中希望控制对FcγRα，FcγRIIA和FcγRIIIA受体的一种或多种的亲和力，ADCC活性，巨噬细胞或单核细胞活化，血清半衰期和 亲和力