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    Bioabsorbable Polymeric Compositions and Medical Devices
    4.
    发明申请
    Bioabsorbable Polymeric Compositions and Medical Devices 审中-公开
    生物可吸收聚合物组合物和医疗器械

    公开(公告)号：US20100093946A1

    公开(公告)日：2010-04-15

    申请号：US12578432

    申请日：2009-10-13

    申请人： G. Lawrence Thatcher ,  Robert J. Cottone

    发明人： G. Lawrence Thatcher ,  Robert J. Cottone

    IPC分类号： C08L67/00

    CPC分类号： A61L31/041 ,  A61L17/12 ,  A61L24/0042 ,  A61L24/043 ,  A61L26/0052 ,  A61L26/009 ,  A61L27/26 ,  A61L27/58 ,  A61L28/0026 ,  A61L28/0057 ,  A61L29/049 ,  A61L29/148 ,  A61L31/148 ,  C08L67/04 ,  C08L2205/02 ,  C08L2666/18

    摘要： The bioabsorbable polymers and compositions of the present invention may be formed into medical devices such as stents that can be crimped onto a catheter system for delivery into a blood vessel. The properties of the bioabsorbable polymers allow for both crimping and expansion of the stent. The crystal properties of the bioabsorbable polymers may change during crimping and/or expansion allowing for improved mechanical properties such as tensile strength and slower degradation kinetics. Typically, bioabsorbable polymers comprise aliphatic polyesters based on lactide backbone such as poly L-lactide, poly D-lactide, poly D,L-lactide, mesolactide, glycolides, lactones, as homopolymers or copolymers, as well as formed in copolymer moieties with co-monomers such as, trimethylene carbonate (TMC) or ε-caprolactone (ECL).

    摘要翻译： 本发明的生物可吸收聚合物和组合物可以形成医疗装置，例如可以卷曲到导管系统上用于输送到血管中的支架。 生物可吸收聚合物的性质允许支架的卷曲和膨胀。 生物可吸收聚合物的结晶特性可以在卷曲和/或膨胀期间改变，从而允许改进的机械性能如拉伸强度和较慢的降解动力学。 通常，生物可吸收聚合物包括基于丙交酯骨架的脂肪族聚酯，例如聚L-丙交酯，聚D-丙交酯，聚D，L-丙交酯，乳酰胺，乙交酯，内酯作为均聚物或共聚物，以及在共聚物部分中与共聚物形成 单体，如三亚甲基碳酸酯（TMC）或ε-己内酯（ECL）。