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公开(公告)号：US11530301B2
公开(公告)日：2022-12-20
申请号：US16066810
申请日：2016-12-28
申请人： GALDERMA S.A.
发明人： Hotan Mojarradi , Johan Olsson , Craig Steven Harris , Jean-Guy Boiteau , Thibaut Gerfaud , Loïc Tomas
IPC分类号： A61K8/04 , A61K8/73 , A61P17/00 , A61Q19/00 , A61K9/00 , C08B37/08 , C08K5/09 , C08K5/08 , C07C209/62 , C07C7/08 , C07C213/00 , C08J3/24 , C08J3/075 , C08L5/00 , C08J7/14 , C07C269/06 , C08B37/00 , C08L5/08 , C07F7/08
摘要： The invention relates to a hydrogel product comprising glycosaminoglycan molecules as the swellable polymer, wherein the glycosaminoglycan molecules are covalently crosslinked via crosslinks comprising a spacer group selected from the group consisting of di-, tri-, tetra-, and oligosaccharides.
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公开(公告)号：US11198765B2
公开(公告)日：2021-12-14
申请号：US16066793
申请日：2016-12-28
申请人： GALDERMA S.A.
发明人： Johan Olsson , Hotan Mojarradi
IPC分类号： C08J3/075 , C08B37/00 , C08B37/08 , C08L5/00 , C08J3/24 , C08L5/08 , C07C209/62 , C07C213/00 , C07C269/06 , C07F7/08 , C08J7/14 , C08K5/09 , A61K8/04 , A61K8/73 , A61Q19/00 , A61K9/00
摘要： A method of preparing a hydrogel product comprising crosslinked glycosaminoglycan molecules, said method including: i) providing a glycosaminoglycan crosslinked by amide bonds, wherein the crosslinked glycosaminoglycans include ester crosslinks formed as byproducts during the amide crosslinking; and ii) subjecting the crosslinked glycosaminoglycans to alkaline treatment to hydrolyze ester crosslinks formed as byproducts during the amide crosslinking.
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公开(公告)号：US10131718B2
公开(公告)日：2018-11-20
申请号：US15314168
申请日：2015-05-29
申请人： GALDERMA S.A.
发明人： Anders Karlsson , Hotan Mojarradi
摘要： A hyaluronic acid product is comprising a cross-linked hyaluronic acid and one or more dextran molecules. The hyaluronic acid is cross-linked by ether bonds, and the one or more dextran molecules are covalently grafted to the cross-linked hyaluronic acid.
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