公开(公告)号：US10899894B2

公开(公告)日：2021-01-26

申请号：US16066985

申请日：2016-12-28

申请人： GALDERMA S.A.

发明人： Johan Olsson ,  Craig Steven Harris

IPC分类号： C08B37/00 ,  C08B37/08 ,  C08L5/08 ,  C08J3/075 ,  C08L5/00 ,  C08J3/24 ,  C07C209/62 ,  C07C213/00 ,  C07C269/06 ,  C07F7/08 ,  C08J7/14 ,  C08K5/09 ,  A61K8/04 ,  A61K8/73 ,  A61Q19/00 ,  A61K9/00

摘要： A method of preparing a hydrogel product including crosslinked glycosaminoglycan molecules, said method including: i) providing a glycosaminoglycan crosslinked by amide bonds, wherein the crosslinked glycosaminoglycans include residual amine groups; and ii) acylating residual amine groups of the crosslinked glycosaminoglycans provided in i) to form acylated crosslinked glycosaminoglycans.

公开(公告)号：US11198765B2

公开(公告)日：2021-12-14

申请号：US16066793

申请日：2016-12-28

申请人： GALDERMA S.A.

发明人： Johan Olsson ,  Hotan Mojarradi

IPC分类号： C08J3/075 ,  C08B37/00 ,  C08B37/08 ,  C08L5/00 ,  C08J3/24 ,  C08L5/08 ,  C07C209/62 ,  C07C213/00 ,  C07C269/06 ,  C07F7/08 ,  C08J7/14 ,  C08K5/09 ,  A61K8/04 ,  A61K8/73 ,  A61Q19/00 ,  A61K9/00

摘要： A method of preparing a hydrogel product comprising crosslinked glycosaminoglycan molecules, said method including: i) providing a glycosaminoglycan crosslinked by amide bonds, wherein the crosslinked glycosaminoglycans include ester crosslinks formed as byproducts during the amide crosslinking; and ii) subjecting the crosslinked glycosaminoglycans to alkaline treatment to hydrolyze ester crosslinks formed as byproducts during the amide crosslinking.

公开(公告)号：US11530301B2

公开(公告)日：2022-12-20

申请号：US16066810

申请日：2016-12-28

申请人： GALDERMA S.A.

发明人： Hotan Mojarradi ,  Johan Olsson ,  Craig Steven Harris ,  Jean-Guy Boiteau ,  Thibaut Gerfaud ,  Loïc Tomas

IPC分类号： A61K8/04 ,  A61K8/73 ,  A61P17/00 ,  A61Q19/00 ,  A61K9/00 ,  C08B37/08 ,  C08K5/09 ,  C08K5/08 ,  C07C209/62 ,  C07C7/08 ,  C07C213/00 ,  C08J3/24 ,  C08J3/075 ,  C08L5/00 ,  C08J7/14 ,  C07C269/06 ,  C08B37/00 ,  C08L5/08 ,  C07F7/08

摘要： The invention relates to a hydrogel product comprising glycosaminoglycan molecules as the swellable polymer, wherein the glycosaminoglycan molecules are covalently crosslinked via crosslinks comprising a spacer group selected from the group consisting of di-, tri-, tetra-, and oligosaccharides.