公开(公告)号：US20140243498A1

公开(公告)日：2014-08-28

申请号：US14348634

申请日：2012-09-28

Applicant: GE HEALTHCARE BIO-SCIENCES AB

Inventor： Eggert Brekkan ,  Kjell Eriksson ,  Bo-Lennart Johansson ,  Jamil Shanagar

IPC: C07K14/62

CPC classification number: C07K14/62 ,  B01D15/361 ,  B01D15/362 ,  B01J20/286 ,  B01J20/288 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3293 ,  B01J39/26

Abstract: The present invention is within the field of biomolecule purification. More closely the invention relates to chromatographic purification of insulin using a specific kind of shell beads having an inner core and an outer functionalized layer. The method enables purification at high flow rates and high purity, over 90%.

Abstract translation: 本发明在生物分子纯化领域内。 更具体地，本发明涉及使用具有内核和外功能化层的特定种类的壳珠的色谱纯化胰岛素。 该方法能够在高流速和高纯度下纯化，超过90％。

公开(公告)号：US09409967B2

公开(公告)日：2016-08-09

申请号：US14348634

申请日：2012-09-28

Applicant: GE HEALTHCARE BIO-SCIENCES AB

Inventor： Eggert Brekkan ,  Kjell Eriksson ,  Bo-Lennart Johansson ,  Jamil Shanagar

IPC: C07K1/18 ,  A61K38/28 ,  B01D15/08 ,  B01D15/26 ,  B01D15/36 ,  B01J20/285 ,  B01J20/286 ,  B01J20/32 ,  C07K14/62 ,  B01J39/26 ,  B01J20/288

CPC classification number: C07K14/62 ,  B01D15/361 ,  B01D15/362 ,  B01J20/286 ,  B01J20/288 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3293 ,  B01J39/26

Abstract: The present invention is within the field of biomolecule purification. More closely the invention relates to chromatographic purification of insulin using a specific kind of shell beads having an inner core and an outer functionalized layer. The method enables purification at high flow rates and high purity, over 90%.

Abstract translation: 本发明在生物分子纯化领域内。 更具体地，本发明涉及使用具有内核和外功能化层的特定种类的壳珠的色谱纯化胰岛素。 该方法能够在高流速和高纯度下纯化，超过90％。