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公开(公告)号：US20200282361A1
公开(公告)日：2020-09-10
申请号：US16077779
申请日：2017-02-21
Applicant: GE HEALTHCARE BIO-SCIENCES AB
Inventor： Klaus Gebauer , Sudheer Mygapula , Nachiket Karmarkar , Sasikumar Arumugam , Bashkar HV , Ajit S. Vernekar , Nityananda Maiya , Prashanth Hosabettu Mohan , Sasi Kumar Nutalapati , Sameera Simha Hindupur , Shashidhar Hedge
Abstract: The invention discloses embodiments of different high precision pinch control valves having an accuracy in the micron range and a method of controlling a transmembrane pressure (TMP) in a crossflow filtration apparatus, comprising the steps of: a) providing a crossflow filtration apparatus comprising a pump (21) fluidically connected via a retentate compartment (33) of a crossflow filter (32) and a length of flexible tubing to Sa regulator valve (1;101) acting on the flexible tubing, wherein the regulator valve is a high precision pinch valve. The apparatus further comprises a first pressure transducer (22) adapted to measure a pressure between the retentate compartment and the regulator valve, a second pressure transducer (39) adapted to measure a pressure between the pump and the retentate compartment and a third pressure transducer (40) adapted to measure a pressure at a permeate outlet (36) of the crossflow filter, and a control unit (23) electrically or electromagnetically connected to said regulator valve, the first, second and third pressure transducers and optionally to the pump; b) pumping a liquid with the pump via the second pressure transducer, through the retentate compartment via the length of flexible tubing, the first pressure transducer and the regulator valve; c) controlling the regulator valve with the control unit, such that a TMP calculated by formula (I) TMP=(Pinlet+Poutlet/2−Pperm (I)
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Patent Agency Ranking
公开(公告)号：US20210017482A1
公开(公告)日：2021-01-21
申请号：US15781217
申请日：2016-11-25
Applicant: GE HEALTHCARE BIO-SCIENCES AB
Inventor： Amit Kumar Singh , Klaus Gebauer , Supti Datta , Jakob Liderfelt , Nachiket Karmarkar , Ajit S. Vernekar , Mats Olsson , Thiyaga Rajan , Amit K. Sharma , Sasi Kumar Nutalapati , Fredrik Lundstrom , Jean Pierre Neff
Abstract: The invention discloses a first unit (1) for treatment of a bioprocess liquid comprising a first lateral face (2), a second lateral face (3) and a front face (4) which meets the two said lateral faces. The front face comprises: a plurality of valves (7) adapted to receive and act upon one or more legs (8) of a disposable flow path (6); optionally one or more pumps (10) adapted to receive and act upon one or more legs of the disposable flow path; optionally one or more sensors (11) adapted to receive and to measure one or more parameters in one or more legs of the disposable flow path; wherein the plurality of valves and optional pumps and sensors are vertically offset from each other to give one or more legs of a disposable flow path received by said valves and optional pumps and sensors a slope of at least 3.0 degrees from the horizontal plane (h).
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公开(公告)号：US20180304199A1
公开(公告)日：2018-10-25
申请号：US15769461
申请日：2016-10-28
Applicant: GE HEALTHCARE BIO-SCIENCES AB
Inventor： Klaus Gebauer , Partha Sarathy Doddapadam Srinivasa Raghavachar , Narendra G R , Nachiket Karmarkar , Ajit S. Vernekar , Prashanth Hosabettu Mohan , Sasi Kumar Nutalapati
CPC classification number: B01D61/20 , B01D2311/25 , B01D2313/083 , B01D2315/16 , B01F5/10 , B01F5/102 , B01F15/00136 , B01F15/00253 , B01F15/0085
Abstract: A method and a system for improving mixing of content in a container 3 provided in a filter system 1, said method comprising providing a mixing loop 13 parallel to a recirculation flow path 11 of the filter system 1.
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公开(公告)号：US20180221823A1
公开(公告)日：2018-08-09
申请号：US15750227
申请日：2016-08-17
Applicant: GE HEALTHCARE BIO-SCIENCES AB
Inventor： Sasi Kumar Nutalapati , Klaus Gebauer , Karl Axel Jakob Liderfelt , Nachiket Karmarkar , Ajit S. Vernekar , Amit Kumar Sharma , Fredrik Oskar Lundstrom
CPC classification number: B01D61/18 , B01D61/08 , B01D61/10 , B01D61/12 , B01D61/20 , B01D61/22 , B01D65/02 , B01D2311/08 , B01D2311/16 , B01D2311/25 , B01D2313/243 , B01D2315/10 , B01D2315/14 , B01D2321/02 , C07K1/34
Abstract: The disclosed subject matter relates to an automated CFF/TFF system that provides the operations of system treatment with a system treatment solution(such as buffer) and filtration of a solution (e.g., a biofluid) can be accomplished in succession without having to re-configure the system (such as re-routing the fluid conduits) that could compromise the integrity of the system. As a result, there will be reduced contamination risk, reduced volume of buffer required and will save time for the filtration process.
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公开(公告)号：US20180221822A1
公开(公告)日：2018-08-09
申请号：US15750218
申请日：2016-08-17
Applicant: GE HEALTHCARE BIO-SCIENCES AB
Inventor： Sasi Kumar Nutalapati , Klaus Gebauer , Karl Axel Jakob Liderfelt , Nachiket Karmarkar , Amit S. Vernekar , Ajit Kumar Sharma , Fredrik Oskar Lundstrom , Sangeetha Raghu Ramachandran
CPC classification number: B01D61/18 , B01D61/08 , B01D61/10 , B01D61/12 , B01D61/20 , B01D61/22 , B01D65/02 , B01D2311/08 , B01D2311/16 , B01D2311/25 , B01D2313/243 , B01D2315/10 , B01D2315/14 , B01D2321/02 , C07K1/34
Abstract: The disclosure generally relates to methods and apparatus for the efficient quantitative recovery of valuable biological fluids from filtration systems, more particularly to efficient quantitative recovery of valuable biological fluids from high precision separation systems suitable for use in the pharmaceutical and biotechnology industries.
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公开(公告)号：USD802710S1
公开(公告)日：2017-11-14
申请号：US29567224
申请日：2016-06-07
Applicant: GE Healthcare Bio-Sciences AB
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