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    Method and System for Transferring Separation Resin
    1.
    发明申请
    Method and System for Transferring Separation Resin 审中-公开

    公开(公告)号：US20200001204A1

    公开(公告)日：2020-01-02

    申请号：US16481655

    申请日：2018-01-30

    Applicant: GE Healthcare Bio-Sciences AB

    Inventor： Johan Avallin ,  Klaus Gebauer

    IPC: B01D15/20 ,  G01N30/56 ,  A61L2/08

    Abstract: A method and a system and a container system for transferring separation resin from at least one first container (3; 3; 3a, 3b; 3a′, 3b′, 3c′, 3d′) to a second container (5; 5′), wherein said first container is a deformable, single-use separation resin storage container, said method comprising the steps of:—preparing (S1) the at least one first container by providing a deformable, single-use container comprising an outlet port (4′) with a predefined volume of separation resin in a storage solution;—fluidizing (S3) the separation resin in the at least one first container to provide a resin slurry, said fluidizing being performed by mechanical interaction to the first container from an outside of the first container to provide a deformation of said first container;—fluidically connecting (S5) the outlet port (4′) of the at least one first container to an inlet port (103) of the second container;—transferring (S7) separation resin from the at least one first container to the second container by generating a pressure difference between an interior of the second container and an interior of the first container where the pressure is lower in the second container.

    Chromatography Column Distribution System
    9.
    发明申请
    Chromatography Column Distribution System 审中-公开
    色谱柱分配系统

    公开(公告)号：US20160144293A1

    公开(公告)日：2016-05-26

    申请号：US15010565

    申请日：2016-01-29

    Applicant: GE Healthcare Bio-Sciences AB

    Inventor： Klaus Gebauer

    IPC: B01D15/14

    CPC classification number: B01D15/14 ,  G01N30/6017 ,  Y10T137/6851

    Abstract: A chromatography column distribution system includes a set of first bed support ribs extending radially from an inner, first radial position near the centre of the plate to an outer radial position nearer to the periphery of the plate and at least one set of intermediate bed support ribs starting at an intermediate radial position and extending to an outer radial position nearer to the periphery of the plate. Channels are formed between adjacent bed support ribs. The desired local effective channel height varies in accordance with a predetermined formula from the first radial position to the outer radial position. The transverse cross-sectional areas of the ribs or the channels are adapted such that the actual local effective channel height is within 15% of the desired local effective channel height over portions of the distribution system situated between the first radial position and the outer radial position. The length of the portions correspond to at least 80% of the distance between the first and outer radial position and the outer radial position.

    Abstract translation: 色谱柱分配系统包括一组第一床支撑肋，其从靠近板的中心的内部第一径向位置径向延伸到更接近板周边的外径向位置，以及至少一组中间床支撑肋 从中间径向位置开始并延伸到靠近板周边的外径向位置。 在相邻的床支撑肋之间形成通道。 期望的局部有效通道高度根据从第一径向位置到外径向位置的预定公式而变化。 肋或通道的横截面积适于使得实际的局部有效通道高度在位于第一径向位置和外径向位置之间的分配系统的部分之上的所需局部有效通道高度的15％以内 。 部分的长度对应于第一和外径向位置与外径向位置之间的距离的至少80％。

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