公开(公告)号：US20210253597A1

公开(公告)日：2021-08-19

申请号：US17153536

申请日：2021-01-20

Applicant: GENENTECH, INC.

Inventor： Steven MCKERRALL ,  Brian Salvatore SAFINA ,  Aleksandr KOLESNIKOV ,  Birong ZHANG ,  Wenfeng LIU ,  Kwong Wah LAI

IPC: C07D498/04 ,  C07D471/04 ,  A61P11/00 ,  A61P9/00 ,  A61P25/24 ,  A61P25/00 ,  A61P29/00

Abstract: The invention provides a compound of formula (I): or a pharmaceutically acceptable salt thereof; wherein, A, B, ring C, R3, R4, R5, R6, and R7 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

公开(公告)号：US20160264567A1

公开(公告)日：2016-09-15

申请号：US15042310

申请日：2016-02-12

Applicant: Genentech, Inc.

Inventor： Po-wai YUEN ,  Anthony ESTRADA ,  Huifen CHEN ,  Aleksandr KOLESNIKOV ,  Elisia VILLEMURE ,  Vishal VERMA ,  Lan WANG ,  Daniel SHORE ,  Steven DO ,  Matthew VOLGRAF ,  Baihua HU ,  Guosheng WU ,  Xingyu LIN ,  Aijun LU

IPC: C07D417/14 ,  C07D403/12 ,  C07D403/14 ,  C07D409/14 ,  C07F9/6512 ,  C07D417/12 ,  C07D405/14 ,  C07D401/14 ,  C07D401/12

CPC classification number: C07D417/14 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/12 ,  C07F9/6512

Abstract: The invention is concerned with the compounds of formula I: and salts thereof and other compounds of formulas II-IX as disclosed herein. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formulas I-IX as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain or asthma.

Abstract translation: 和其盐和本文公开的其它式II-IX化合物。 此外，本发明涉及制造方法和使用式I-IX化合物的方法以及含有这些化合物的药物组合物。 该化合物可用于治疗由TRPA1介导的疾病和病症，例如疼痛或哮喘。

公开(公告)号：US20250042917A1

公开(公告)日：2025-02-06

申请号：US18912279

申请日：2024-10-10

Applicant: Genentech, Inc.

Inventor： Steven MCKERRALL ,  Brian Salvatore SAFINA ,  Aleksandr KOLESNIKOV ,  Birong ZHANG ,  Wenfeng LIU ,  Kwong Wah LAI

IPC: C07D498/04 ,  A61K31/4375 ,  A61K31/5365 ,  A61P9/00 ,  A61P11/00 ,  A61P25/00 ,  A61P25/24 ,  A61P29/00 ,  C07D471/04

Abstract: The invention provides a compound of formula (I): or a pharmaceutically acceptable salt thereof; wherein, A, B, ring C, R3, R4, R5, R6, and R7 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

公开(公告)号：US20200262845A1

公开(公告)日：2020-08-20

申请号：US16863741

申请日：2020-04-30

Applicant: Genentech, Inc.

Inventor： Marian C. BRYAN ,  Joy DROBNICK ,  James Richard KIEFER, JR. ,  Aleksandr KOLESNIKOV ,  Naomi S. RAJAPAKSA

IPC: C07D519/00

Abstract: Compounds of Formula I and methods of use as Interleukin-1 Receptor Associated Kinase 4 (IRAK4) inhibitors are described herein.

公开(公告)号：US20200048197A1

公开(公告)日：2020-02-13

申请号：US16657102

申请日：2019-10-18

Applicant: Genentech, Inc.

Inventor： Huifen CHEN ,  Yanyan CHU ,  Steven DO ,  Anthony ESTRADA ,  Baihua HU ,  Aleksandr KOLESNIKOV ,  Xingyu LIN ,  Joseph P. LYSSIKATOS ,  Daniel SHORE ,  Vishal VERMA ,  Lan WANG ,  Guosheng WU ,  Po-wai YUEN

IPC: C07D207/48 ,  C07D403/12 ,  C07D401/14 ,  C07D401/12 ,  C07D403/14 ,  C07D417/12 ,  C07D451/02 ,  C07D491/048 ,  C07D405/14

Abstract: The invention is concerned with the compounds of formula I or II: and salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I or II as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.

公开(公告)号：US20190300544A1

公开(公告)日：2019-10-03

申请号：US16370756

申请日：2019-03-29

Applicant: GENENTECH, INC.

Inventor： Steven MCKERRALL ,  Brian Salvatore SAFINA ,  Aleksandr KOLESNIKOV ,  Birong ZHANG ,  Wenfeng LIU ,  Kwong Wah LAI

IPC: C07D498/04 ,  C07D471/04 ,  A61P25/24 ,  A61P9/00 ,  A61P11/00

Abstract: The invention provides a compound of formula (I): or a pharmaceutically acceptable salt thereof; wherein, A, B, ring C, R3, R4, R5, R6, and R7 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

公开(公告)号：US20180282272A1

公开(公告)日：2018-10-04

申请号：US16001770

申请日：2018-06-06

Applicant: Genentech, Inc.

Inventor： Huifen CHEN ,  Yanyan CHU ,  Steven DO ,  Anthony ESTRADA ,  Baihua HU ,  Aleksandr KOLESNIKOV ,  Xingyu LIN ,  Joseph P. LYSSIKATOS ,  Daniel SHORE ,  Vishal VERMA ,  Lan WANG ,  Guosheng WU ,  Po-wai YUEN

IPC: C07D207/48 ,  C07D451/02 ,  C07D491/048 ,  C07D401/14 ,  C07D405/14 ,  C07D403/14 ,  C07D403/12 ,  C07D417/12 ,  C07D401/12

Abstract: The invention is concerned with the compounds of formula I or II: and salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I or II as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.

公开(公告)号：US20160221945A1

公开(公告)日：2016-08-04

申请号：US15095467

申请日：2016-04-11

Applicant: Genentech, Inc.

Inventor： Huifen CHEN ,  Yanyan CHU ,  Steven DO ,  Anthony ESTRADA ,  Baihua HU ,  Aleksandr KOLESNIKOV ,  Xingyu LIN ,  Joseph P. LYSSIKATOS ,  Daniel SHORE ,  Vishal VERMA ,  Lan WANG ,  Guosheng WU ,  Po-wai YUEN

IPC: C07D207/48 ,  C07D403/12 ,  C07D403/14 ,  C07D417/12 ,  C07D405/14 ,  C07D491/048 ,  C07D451/02 ,  C07D401/14 ,  C07D401/12

Abstract: The invention is concerned with the compounds of formula I or II: and salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I or II as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.

Abstract translation: 本发明涉及式I或II化合物及其盐。 此外，本发明涉及制备方法和使用式I或II化合物的方法以及含有这些化合物的药物组合物。 该化合物可用于治疗TRPA1介导的疾病和病症，例如疼痛。