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公开(公告)号:US20210253597A1
公开(公告)日:2021-08-19
申请号:US17153536
申请日:2021-01-20
Applicant: GENENTECH, INC.
Inventor: Steven MCKERRALL , Brian Salvatore SAFINA , Aleksandr KOLESNIKOV , Birong ZHANG , Wenfeng LIU , Kwong Wah LAI
IPC: C07D498/04 , C07D471/04 , A61P11/00 , A61P9/00 , A61P25/24 , A61P25/00 , A61P29/00
Abstract: The invention provides a compound of formula (I): or a pharmaceutically acceptable salt thereof; wherein, A, B, ring C, R3, R4, R5, R6, and R7 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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公开(公告)号:US20210214336A1
公开(公告)日:2021-07-15
申请号:US17056325
申请日:2019-05-21
Applicant: GENENTECH, INC.
Inventor: Steven MCKERRALL , Ramsay BEVERIDGE , Kwong Wah LAI , Philippe BERGERON
IPC: C07D401/12 , A61P17/04 , A61K9/00 , A61P29/00
Abstract: The invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein the variables Y1-Y6, X, Z, Z1, Z2, R2-R3, and R6 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions. The compounds have sodium channel blocking activity that are useful for treating sodium channel-mediated diseases, in particular for treating pain
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公开(公告)号:US20210107895A1
公开(公告)日:2021-04-15
申请号:US17031492
申请日:2020-09-24
Applicant: GENENTECH, INC.
Inventor: Daniel SUTHERLIN , Steven MCKERRALL , Kwong Wah LAI
IPC: C07D401/14
Abstract: The invention provides a compounds and salts that are sodium channel modulators, as well as compositions containing such a compound or salt and therapeutic methods for using such a compound, salt, or composition.
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公开(公告)号:US20250042917A1
公开(公告)日:2025-02-06
申请号:US18912279
申请日:2024-10-10
Applicant: Genentech, Inc.
Inventor: Steven MCKERRALL , Brian Salvatore SAFINA , Aleksandr KOLESNIKOV , Birong ZHANG , Wenfeng LIU , Kwong Wah LAI
IPC: C07D498/04 , A61K31/4375 , A61K31/5365 , A61P9/00 , A61P11/00 , A61P25/00 , A61P25/24 , A61P29/00 , C07D471/04
Abstract: The invention provides a compound of formula (I): or a pharmaceutically acceptable salt thereof; wherein, A, B, ring C, R3, R4, R5, R6, and R7 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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公开(公告)号:US20240239766A1
公开(公告)日:2024-07-18
申请号:US18584298
申请日:2024-02-22
Applicant: Genentech, Inc.
Inventor: Steven John MCKERRALL , Daniel Fred ORTWINE , Philippe BERGERON , Ramsay BEVERIDGE , Elise GHIRO , Kwong Wah LAI , Guqin SHI
IPC: C07D401/12 , A61K31/454 , A61K31/506 , A61P17/04 , A61P29/00 , C07D401/14 , C07D405/14 , C07D413/12 , C07D417/12
CPC classification number: C07D401/12 , A61K31/454 , A61K31/506 , A61P17/04 , A61P29/00 , C07D401/14 , C07D405/14 , C07D413/12 , C07D417/12
Abstract: The invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein Z1, Z2, R3-R8, RA, ring A, and n have the meanings described herein, and compositions containing such compounds and methods for using such compounds and compositions for the treatment of pain.
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公开(公告)号:US20190263786A1
公开(公告)日:2019-08-29
申请号:US16283451
申请日:2019-02-22
Applicant: GENENTECH, INC.
Inventor: Daniel SUTHERLIN , Steven MCKERRALL , Kwong Wah LAI , Zhiguo LIU , Wenfeng LIU , Ramsay BEVERIDGE , Jean-Philippe LECLERC , Alexandre LEMIRE , Liang ZHAO , Claudio STURINO
IPC: C07D403/12 , C07D233/96 , C07D401/12 , C07D401/14 , C07D263/52 , C07D305/06 , A61P17/04
Abstract: The invention provides a compound as described herein or a pharmaceutically acceptable salt thereof, and compositions containing such compounds and methods for using such compounds and compositions.
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公开(公告)号:US20230159555A1
公开(公告)日:2023-05-25
申请号:US17814115
申请日:2022-07-21
Applicant: Genentech, Inc.
Inventor: Paul GIBBONS , Kwong Wah LAI , Christian NILEWSKI , Richard M. PASTOR , Steven Thomas STABEN , Craig STIVALA , Bing-Yan ZHU , Huifen CHEN
IPC: C07D498/04
CPC classification number: C07D498/04
Abstract: Described herein are compounds of Formula (I), Formula (I-A), and Formula (I-B),
solvates thereof, tautomers thereof, and pharmaceutically acceptable salts of the foregoing, Further described herein are methods of inhibiting NLRP3 using said compounds, and methods of and compositions useful in treating NLRP3-dependent disorders.-
公开(公告)号:US20220081423A1
公开(公告)日:2022-03-17
申请号:US17331164
申请日:2021-05-26
Applicant: GENENTECH, INC.
Inventor: Daniel SUTHERLIN , Steven MCKERRALL , Kwong Wah LAI , Zhiguo LIU , Wenfeng LIU , Ramsay BEVERIDGE , Jean-Philippe LECLERC , Alexandre LEMIRE , Liang ZHAO , Claudio STURINO
IPC: C07D403/12 , C07D233/96 , C07D401/12 , A61P17/04 , C07D263/52 , C07D305/06 , C07D401/14 , A61K31/506 , A61K31/538 , C07D413/12 , C07B59/00 , A61K31/63 , A61K45/06 , C07D239/69 , A61K31/505
Abstract: The invention provides benzene sulfonamides and pharmaceutically acceptable salt thereof that are useful as sodium channel blockers for the treatment of, for example, pain. The following compound is illustrative:
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公开(公告)号:US20180291014A1
公开(公告)日:2018-10-11
申请号:US15939112
申请日:2018-03-28
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor: Phillipe BERGERON , Kristen BURFORD , Sultan CHOWDHURY , Christoph Martin DEHNHARDT , Thilo FOCKEN , Michael Edward GRIMWOOD , Abid HASAN , Kwong Wah LAI , Zhiguo LIU , Steven MCKERRALL , Teresa Phuongtram NGUYEN , Brian SAFINA , Daniel SUTHERLIN , Tao WANG
IPC: C07D417/12 , C07D417/14 , C07D401/12 , C07D405/14 , C07D491/107 , A61P17/04
Abstract: The invention provides a compound of formula: or a salt thereof, wherein the variables RAA, n, ring A, ring B, R1a, R1b, R2, R3, R4, R5, R6, R7, R8, and R9 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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公开(公告)号:US20250115576A1
公开(公告)日:2025-04-10
申请号:US18985502
申请日:2024-12-18
Applicant: Genentech, Inc.
Inventor: Steven MCKERRALL , Ramsay BEVERIDGE , Kwong Wah LAI , Philippe BERGERON
IPC: C07D401/12 , A61K31/4439 , A61K31/506 , A61K31/5377 , C07D401/14 , C07D413/12
Abstract: The invention provides a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein the variables Y1-Y6, X, Z, Z1, Z2, R2-R3, and R6 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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