公开(公告)号：US20210253597A1

公开(公告)日：2021-08-19

申请号：US17153536

申请日：2021-01-20

Applicant: GENENTECH, INC.

Inventor： Steven MCKERRALL ,  Brian Salvatore SAFINA ,  Aleksandr KOLESNIKOV ,  Birong ZHANG ,  Wenfeng LIU ,  Kwong Wah LAI

IPC: C07D498/04 ,  C07D471/04 ,  A61P11/00 ,  A61P9/00 ,  A61P25/24 ,  A61P25/00 ,  A61P29/00

Abstract: The invention provides a compound of formula (I): or a pharmaceutically acceptable salt thereof; wherein, A, B, ring C, R3, R4, R5, R6, and R7 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

公开(公告)号：US20250042917A1

公开(公告)日：2025-02-06

申请号：US18912279

申请日：2024-10-10

Applicant: Genentech, Inc.

Inventor： Steven MCKERRALL ,  Brian Salvatore SAFINA ,  Aleksandr KOLESNIKOV ,  Birong ZHANG ,  Wenfeng LIU ,  Kwong Wah LAI

IPC: C07D498/04 ,  A61K31/4375 ,  A61K31/5365 ,  A61P9/00 ,  A61P11/00 ,  A61P25/00 ,  A61P25/24 ,  A61P29/00 ,  C07D471/04

Abstract: The invention provides a compound of formula (I): or a pharmaceutically acceptable salt thereof; wherein, A, B, ring C, R3, R4, R5, R6, and R7 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

公开(公告)号：US20190300544A1

公开(公告)日：2019-10-03

申请号：US16370756

申请日：2019-03-29

Applicant: GENENTECH, INC.

Inventor： Steven MCKERRALL ,  Brian Salvatore SAFINA ,  Aleksandr KOLESNIKOV ,  Birong ZHANG ,  Wenfeng LIU ,  Kwong Wah LAI

IPC: C07D498/04 ,  C07D471/04 ,  A61P25/24 ,  A61P9/00 ,  A61P11/00

Abstract: The invention provides a compound of formula (I): or a pharmaceutically acceptable salt thereof; wherein, A, B, ring C, R3, R4, R5, R6, and R7 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

公开(公告)号：US20180105504A1

公开(公告)日：2018-04-19

申请号：US15799771

申请日：2017-10-31

Applicant: GENENTECH, INC. ,  XENON PHARMACEUTICALS INC.

Inventor： Daniel SUTHERLIN ,  Steven MCKERRALL ,  Michael Scott WILSON ,  Kwong Wah LAI ,  Philippe BERGERON ,  Birong ZHANG

IPC: C07D277/52 ,  C07D239/69 ,  C07D285/08 ,  C07D417/12 ,  C07D213/76 ,  C07D401/12 ,  C07D403/12 ,  C07D261/16

CPC classification number: C07D277/52 ,  A61K31/427 ,  A61P19/02 ,  A61P29/00 ,  C07D213/76 ,  C07D239/69 ,  C07D261/16 ,  C07D285/08 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12

Abstract: The invention provides a compound of formula I: or a pharmaceutically acceptable salt thereof, wherein the variables X, Y1-Y5, R1, R2, R3, R4, and Het have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.