公开(公告)号：US20210309989A1

公开(公告)日：2021-10-07

申请号：US17213611

申请日：2021-03-26

Applicant: GENENTECH, INC.

Inventor： Michael Wilson LAIRD ,  Shahram MISAGHI ,  Amy SHEN ,  Anthony TOMLINSON ,  Inn Huam YUK

IPC: C12N15/10 ,  C12N5/071

Abstract: The present disclosure relates to methods, cells, and compositions for producing a product of interest, e.g., a recombinant protein. In particular, the present disclosure provides improved mammalian cells expressing the product of interest, where the cells (e.g., Chinese Hamster Ovary (CHO) cells) have reduced or eliminated activity, e.g., expression, of certain host cell proteins, e.g., enzymes including, but not limited to, certain lipases, esterases, and/or hydrolases.

公开(公告)号：US20210015920A1

公开(公告)日：2021-01-21

申请号：US16914100

申请日：2020-06-26

Applicant: Genentech, Inc.

Inventor： Anthony TOMLINSON ,  Barthelemy Luc DEMEULE ,  Isidro Angelo Eleazar ZARRAGA

IPC: A61K39/395 ,  A61K9/19 ,  A61K9/08 ,  A61K47/22

Abstract: The present disclosure provides liquid formulations comprising polypeptides and surfactants. In particular, it discloses a liquid formulation comprising a polypeptide and a surfactant, wherein at least about 70% (wt %) of the surfactant are isosorbide polyoxyethylene (POE) fatty acid esters. The invention also provides methods for making such liquid formulations, articles of manufacture comprising such liquid formulations and methods of treating a patient with such liquid formulations.

公开(公告)号：US20250101411A1

公开(公告)日：2025-03-27

申请号：US18823189

申请日：2024-09-03

Applicant: Genentech, Inc.

Inventor： Michael Wilson LAIRD ,  Shahram MISAGHI ,  Amy SHEN ,  Anthony TOMLINSON ,  Inn Huam YUK

IPC: C12N15/10 ,  C12N5/071

Abstract: The present disclosure relates to methods, cells, and compositions for producing a product of interest, e.g., a recombinant protein. In particular, the present disclosure provides improved mammalian cells expressing the product of interest, where the cells (e.g., Chinese Hamster Ovary (CHO) cells) have reduced or eliminated activity, e.g., expression, of certain host cell proteins, e.g., enzymes including, but not limited to, certain lipases, esterases, and/or hydrolases.

公开(公告)号：US20240123066A1

公开(公告)日：2024-04-18

申请号：US18531442

申请日：2023-12-06

Applicant: Genentech, Inc.

Inventor： Anthony TOMLINSON ,  Barthelemy Luc DEMEULE ,  Isidro Angelo Eleazar ZARRAGA

IPC: A61K39/395 ,  A61K9/08 ,  A61K9/19 ,  A61K47/22

CPC classification number: A61K39/39591 ,  A61K9/08 ,  A61K9/19 ,  A61K47/22

Abstract: The present disclosure provides liquid formulations comprising polypeptides and surfactants. In particular, it discloses a liquid formulation comprising a polypeptide and a surfactant, wherein at least about 70% (wt %) of the surfactant are isosorbide polyoxyethylene (POE) fatty acid esters. The invention also provides methods for making such liquid formulations, articles of manufacture comprising such liquid formulations and methods of treating a patient with such liquid formulations.