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公开(公告)号：US20140363439A1
公开(公告)日：2014-12-11
申请号：US14466794
申请日：2014-08-22
Applicant: GENENTECH, INC.
Inventor： Eric Bourhis , Rick Carano , Andrea Cochran , Mike Costa , Venita DeAlmeida , James Ernst , Yan Gong , Rami Hannoush , Paul Polakis , Bonnee Rubinfeld , Mark Solloway , Yan Wu
IPC: C07K16/28 , A61K39/395
CPC classification number: C07K16/28 , A61K39/3955 , A61K2039/505 , A61K2039/507 , C07K16/2863 , C07K2317/21 , C07K2317/31 , C07K2317/34 , C07K2317/526 , C07K2317/55 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2319/00
Abstract: The invention provides anti-LRP6 antibodies and methods of using the same. A particular aspect of the invention provides for bispecific anti-LRP6 antibodies that inhibit signaling by multiple Wnt isoforms.
Abstract translation: 本发明提供抗LRP6抗体及其使用方法。 本发明的一个特定方面提供了抑制多种Wnt同种型的信号通路的双特异性抗LRP6抗体。
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2.发明授权公开(公告)号：US08771966B2
公开(公告)日：2014-07-08
申请号：US13692888
申请日：2012-12-03
Applicant: Genentech, Inc.
Inventor： Mark Dennis , Jan Marik , Paul Polakis , Bonnee Rubinfeld , Simon Williams
IPC: G01N33/53
CPC classification number: C07K16/40 , A61K47/6811 , A61K47/6871 , A61K51/1072 , A61K51/1075 , A61K51/1093 , A61K51/1096 , A61K2039/505 , C07B59/008 , C07B2200/05 , C07K16/3069 , C07K2317/24 , C07K2317/565 , C07K2317/92 , G01N33/534 , G01N33/57492 , G01N33/60 , G01N33/6893
Abstract: Anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of using anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of detecting or determining the presence of STEAP-1 proteins are provided.
Abstract translation: 提供抗STEAP-1抗体及其免疫偶联物。 提供了使用抗STEAP-1抗体及其免疫偶联物的方法。 提供检测或确定STEAP-1蛋白存在的方法。
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公开(公告)号：US20140080152A1
公开(公告)日：2014-03-20
申请号：US13963286
申请日：2013-08-09
Applicant: Genentech, Inc.
Inventor： Mark Dennis , Bonnee Rubinfeld , Paul Polakis
IPC: C07K16/18
CPC classification number: C07K16/30 , A61K31/537 , A61K45/06 , A61K47/6803 , A61K47/6809 , A61K47/6813 , A61K47/6817 , A61K47/6849 , A61K47/6851 , A61K47/6857 , A61K47/6869 , A61K2039/505 , C07K16/18 , C07K16/28 , C07K16/3023 , C07K16/3069 , C07K2317/14 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/57423 , G01N33/57449 , G01N33/57492
Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号：US20140363873A1
公开(公告)日：2014-12-11
申请号：US14273308
申请日：2014-05-08
Applicant: Genentech, Inc.
Inventor： Mark Dennis , Bonnee Rubinfeld , Paul Polakis
IPC: C07K16/30
CPC classification number: C07K16/30 , A61K31/537 , A61K45/06 , A61K47/6803 , A61K47/6809 , A61K47/6813 , A61K47/6817 , A61K47/6849 , A61K47/6851 , A61K47/6857 , A61K47/6869 , A61K2039/505 , C07K16/18 , C07K16/28 , C07K16/3023 , C07K16/3069 , C07K2317/14 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/57423 , G01N33/57449 , G01N33/57492
Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号：US08889847B2
公开(公告)日：2014-11-18
申请号：US13766150
申请日：2013-02-13
Applicant: Genentech, Inc.
Inventor： Mark S. Dennis , Bonnee Rubinfeld , Paul Polakis , Aya Jakobovits
CPC classification number: G01N33/57434 , A61K38/05 , A61K39/39558 , A61K45/06 , A61K47/6851 , A61K47/6869 , A61K47/6871 , A61K49/0002 , A61K49/0058 , A61K51/1045 , A61K51/1072 , A61K2039/505 , C07K16/30 , C07K16/3069 , C07K16/40 , C07K17/00 , C07K2317/24 , C07K2317/31 , C07K2317/515 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/92
Abstract: Anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of using anti-STEAP-1 antibodies and immunoconjugates thereof are provided.
Abstract translation: 提供抗STEAP-1抗体及其免疫偶联物。 提供了使用抗STEAP-1抗体及其免疫偶联物的方法。
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Patent Agency Ranking
公开(公告)号：US08871911B2
公开(公告)日：2014-10-28
申请号：US13963286
申请日：2013-08-09
Applicant: Genentech, Inc.
Inventor： Mark Dennis , Bonnee Rubinfeld , Paul Polakis
CPC classification number: C07K16/30 , A61K31/537 , A61K45/06 , A61K47/6803 , A61K47/6809 , A61K47/6813 , A61K47/6817 , A61K47/6849 , A61K47/6851 , A61K47/6857 , A61K47/6869 , A61K2039/505 , C07K16/18 , C07K16/28 , C07K16/3023 , C07K16/3069 , C07K2317/14 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/57423 , G01N33/57449 , G01N33/57492
Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号：US20220204640A1
公开(公告)日：2022-06-30
申请号：US17655136
申请日：2022-03-16
Applicant: Genentech, Inc.
Inventor： Mark Dennis , Bonnee Rubinfeld , Paul Polakis
IPC: C07K16/30 , C07K16/28 , G01N33/574 , A61K45/06 , C07K16/18 , A61K31/537 , A61K47/68
Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号：US20180106809A1
公开(公告)日：2018-04-19
申请号：US15849962
申请日：2017-12-21
Applicant: Genentech, Inc.
Inventor： Mark S. Dennis , Bonnee Rubinfeld , Paul Polakis , Aya Jakobovits
IPC: G01N33/574 , A61K47/68 , A61K49/00
CPC classification number: G01N33/57434 , A61K38/05 , A61K39/39558 , A61K45/06 , A61K47/6851 , A61K47/6869 , A61K47/6871 , A61K49/0002 , A61K49/0058 , A61K51/1045 , A61K51/1072 , A61K2039/505 , C07K16/30 , C07K16/3069 , C07K16/40 , C07K17/00 , C07K2317/24 , C07K2317/31 , C07K2317/515 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/92
Abstract: Anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of using anti-STEAP-1 antibodies and immunoconjugates thereof are provided.
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公开(公告)号：US09593167B2
公开(公告)日：2017-03-14
申请号：US14517682
申请日：2014-10-17
Applicant: Genentech, Inc.
Inventor： Mark S. Dennis , Bonnee Rubinfeld , Paul Polakis , Aya Jakobovits
IPC: C07K16/00 , C07K16/40 , A61K47/48 , A61K49/00 , A61K51/10 , C07K16/30 , A61K38/05 , A61K39/395 , A61K45/06 , A61K39/00
CPC classification number: G01N33/57434 , A61K38/05 , A61K39/39558 , A61K45/06 , A61K47/6851 , A61K47/6869 , A61K47/6871 , A61K49/0002 , A61K49/0058 , A61K51/1045 , A61K51/1072 , A61K2039/505 , C07K16/30 , C07K16/3069 , C07K16/40 , C07K17/00 , C07K2317/24 , C07K2317/31 , C07K2317/515 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/92
Abstract: Anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of using anti-STEAP-1 antibodies and immunoconjugates thereof are provided.
Abstract translation: 提供抗STEAP-1抗体及其免疫偶联物。 提供了使用抗STEAP-1抗体及其免疫偶联物的方法。
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公开(公告)号：US20130143237A1
公开(公告)日：2013-06-06
申请号：US13689407
申请日：2012-11-29
Applicant: Genentech, Inc.
Inventor： Siminder Atwal , Jo-Anne Hongo , Mark Lackner , Elizabeth Punnoose , Bonnee Rubinfeld , Rajesh Vij
CPC classification number: G01N33/57434 , C07K16/3069 , C12N5/0693 , C12Y116/01 , C12Y301/03048 , G01N33/57492 , G01N2333/4742 , G01N2333/70596 , G01N2333/90287 , G01N2333/916 , G01N2800/52
Abstract: The invention provides methods for diagnosing prostate cancer. The invention also provides novel anti-STEAP-1 antibodies and uses thereof.
Abstract translation: 本发明提供诊断前列腺癌的方法。 本发明还提供新的抗STEAP-1抗体及其用途。
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