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    Highly selective chemical and biological sensors
    1.
    发明授权
    Highly selective chemical and biological sensors 有权

    公开(公告)号：US09638653B2

    公开(公告)日：2017-05-02

    申请号：US14710299

    申请日：2015-05-12

    Applicant: General Electric Company

    Inventor： Radislav Alexandrovich Potyrailo ,  Cheryl Margaret Surman ,  Andrew Arthur Paul Burns ,  Nandini Nagraj

    IPC: G01N27/02 ,  G01N33/487 ,  G01N33/483

    CPC classification number: G01N27/026 ,  G01N27/02 ,  G01N33/483 ,  G01N33/48792

    Abstract: Methods and sensors for selective fluid sensing are provided. Each sensor includes a resonant inductor-capacitor-resistor (LCR) sensor that is coated with a sensing material. In order to collect data, an impedance spectrum is acquired over a relatively narrow frequency range, such as the resonant frequency range of the LCR circuit. A multivariate signature may be calculated from the acquired spectrum to discern the presence of certain fluids and/or fluid mixtures. The presence of fluids is detected by measuring the changes in dielectric, dimensional, resistance, charge transfer, and other changes in the properties of the materials employed by observing the changes in the resonant electronic properties of the circuit. By using a mathematical procedure, such as principal components analysis (PCA) and others, multiple fluids and mixtures can be detected in the presence of one another, even in a high humidity environment or an environment wherein one or more fluids has a substantially higher concentration (e.g. 10×, 1,000,000×) compared to other components in the mixture.

    HIGHLY SELECTIVE CHEMICAL AND BIOLOGICAL SENSORS
    3.
    发明申请
    HIGHLY SELECTIVE CHEMICAL AND BIOLOGICAL SENSORS 审中-公开
    高选择性化学和生物传感器

    公开(公告)号：US20140025313A1

    公开(公告)日：2014-01-23

    申请号：US14031951

    申请日：2013-09-19

    Applicant: General Electric Company

    Inventor： Radislav Alexandrovich Potyrailo ,  Cheryl Margaret Surman ,  Andrew Arthur Paul Burns ,  Nandini Nagraj

    IPC: G01N27/02

    CPC classification number: G01N27/026 ,  G01N27/02 ,  G01N33/483 ,  G01N33/48792

    Abstract: Methods and sensors for selective fluid sensing are provided. Each sensor includes a resonant inductor-capacitor-resistor (LCR) sensor that is coated with a sensing material. In order to collect data, an impedance spectrum is acquired over a relatively narrow frequency range, such as the resonant frequency range of the LCR circuit. A multivariate signature may be calculated from the acquired spectrum to discern the presence of certain fluids and/or fluid mixtures. The presence of fluids is detected by measuring the changes in dielectric, dimensional, resistance, charge transfer, and other changes in the properties of the materials employed by observing the changes in the resonant electronic properties of the circuit. By using a mathematical procedure, such as principal components analysis (PCA) and others, multiple fluids and mixtures can be detected in the presence of one another, even in a high humidity environment or an environment wherein one or more fluids has a substantially higher concentration (e.g. 10×, 1,000,000×) compared to other components in the mixture.

    Abstract translation: 提供了选择性流体感测的方法和传感器。 每个传感器包括一个涂有传感材料的谐振电感 - 电容电阻（LCR）传感器。 为了收集数据，在相对窄的频率范围（例如LCR电路的谐振频率范围）上获取阻抗谱。 可以从所获得的光谱计算多变量特征，以辨别某些流体和/或流体混合物的存在。 通过观察电路的谐振电子特性的变化来测量所用材料的介电性质，尺寸，电阻，电荷转移和其它变化的变化来检测流体的存在。 通过使用诸如主成分分析（PCA）等的数学方法，可以在彼此存在的情况下检测多种流体和混合物，即使在高湿度环境或其中一种或多种流体具有显着更高浓度的环境中 （例如10×1,000,000×）与混合物中的其他成分相比。

    WEARABLE DEVICE FOR ON-DEMAND INTERSTITIAL FLUID BIOMARKER SENSING WITH A MICRONEEDLE-INTEGRATED SENSOR
    4.
    发明申请
    WEARABLE DEVICE FOR ON-DEMAND INTERSTITIAL FLUID BIOMARKER SENSING WITH A MICRONEEDLE-INTEGRATED SENSOR 有权

    公开(公告)号：US20250064348A1

    公开(公告)日：2025-02-27

    申请号：US18456146

    申请日：2023-08-25

    Applicant: General Electric Company

    Inventor： Andrew Arthur Paul Burns ,  Azar Alizadeh ,  Ralf Lenigk ,  Richard JeanLuc St. Pierre

    IPC: A61B5/145 ,  A61B5/00

    Abstract: A microneedle actuator for monitoring ISF of a user includes a rigid support defining a slot, a geared cam positioned within the rigid support and including an axle extending through the slot, and a spring positioned within the rigid support and configured to rotate the geared cam about the axle. The microneedle actuator further includes an ISF sensing module and an actuation device. The ISF sensing module is attached to the geared cam and including a plurality of microneedles, each microneedle of the plurality of microneedles including at least one sensor for detecting the ISF of the user. The actuation device is attached to the rigid support and the geared cam. Actuation of the actuation device releases the spring, rotating the geared cam to insert the plurality of microneedles into the user's skin, and wherein the at least one sensor detects constituents of the ISF of the user.

    AMPLIFICATION AND DETECTION OF NUCLEIC ACIDS
    6.
    发明申请
    AMPLIFICATION AND DETECTION OF NUCLEIC ACIDS 审中-公开
    核酸的放大和检测

    公开(公告)号：US20170022550A1

    公开(公告)日：2017-01-26

    申请号：US14807497

    申请日：2015-07-23

    Applicant: GENERAL ELECTRIC COMPANY ,  University of Washington

    Inventor： David Roger Moore ,  Matthew Jeremiah Misner ,  Andrew Arthur Paul Burns ,  John Bishop ,  Lisa K. Lafleur ,  Maxwell Wheeler

    IPC: C12Q1/68 ,  B01L7/00

    CPC classification number: B01L7/52 ,  B01L3/5023 ,  B01L3/502738 ,  B01L2200/027 ,  B01L2200/10 ,  B01L2300/0627 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2300/126 ,  B01L2300/18 ,  B01L2400/06 ,  C12Q1/6806 ,  C12Q1/6844 ,  C12Q2565/629

    Abstract: The present disclosure relates to a sample assessment device. By way of example, the sample assessment device may include a substrate including a sample application region; an amplification region comprising a plurality of amplification reagents; a waste region comprising an entrance fluidically coupled to the amplification region and extending away from the amplification region; and a detection region spaced apart from the amplification region. The sample assessment device may also include a valve coupled to the substrate and configured to separate the amplification region from the detection region in a closed configuration, wherein the amplification region and the valve are positioned on the sample assessment device between the sample application region and the detection region and wherein the sample assessment device is configured to permit lateral flow from the amplification region to the detection region when the valve is in an open configuration.

    Abstract translation: 本公开涉及一种样本评估装置。 作为示例，样本评估装置可以包括包括样本应用区域的基板; 包含多个扩增试剂的扩增区; 废物区域，包括流体耦合到所述放大区域并远离所述放大区域延伸的入口; 以及与放大区域间隔开的检测区域。 样品评估装置还可以包括连接到衬底并被配置为在闭合配置中将放大区域与检测区域分开的阀，其中放大区域和阀被定位在样品评估装置之间，样品施加区域和 检测区域，并且其中所述样本评估装置被配置为当所述阀处于打开构型时允许从所述放大区域到所述检测区域的横向流动。

    HIGHLY SELECTIVE CHEMICAL AND BIOLOGICAL SENSORS
    7.
    发明申请
    HIGHLY SELECTIVE CHEMICAL AND BIOLOGICAL SENSORS 审中-公开
    高选择性化学和生物传感器

    公开(公告)号：US20160223484A1

    公开(公告)日：2016-08-04

    申请号：US14710299

    申请日：2015-05-12

    Applicant: General Electric Company

    Inventor： Radislav Alexandrovich Potyrailo ,  Cheryl Margaret Surman ,  Andrew Arthur Paul Burns ,  Nandini Nagraj

    IPC: G01N27/02 ,  G01N33/483

    CPC classification number: G01N27/026 ,  G01N27/02 ,  G01N33/483 ,  G01N33/48792

    Abstract: Methods and sensors for selective fluid sensing are provided. Each sensor includes a resonant inductor-capacitor-resistor (LCR) sensor that is coated with a sensing material. In order to collect data, an impedance spectrum is acquired over a relatively narrow frequency range, such as the resonant frequency range of the LCR circuit. A multivariate signature may be calculated from the acquired spectrum to discern the presence of certain fluids and/or fluid mixtures. The presence of fluids is detected by measuring the changes in dielectric, dimensional, resistance, charge transfer, and other changes in the properties of the materials employed by observing the changes in the resonant electronic properties of the circuit. By using a mathematical procedure, such as principal components analysis (PCA) and others, multiple fluids and mixtures can be detected in the presence of one another, even in a high humidity environment or an environment wherein one or more fluids has a substantially higher concentration (e.g. 10×, 1,000,000×) compared to other components in the mixture.

    Abstract translation: 提供了选择性流体感测的方法和传感器。 每个传感器包括一个涂有传感材料的谐振电感 - 电容电阻（LCR）传感器。 为了收集数据，在相对窄的频率范围（例如LCR电路的谐振频率范围）上获取阻抗谱。 可以从所获得的光谱计算多变量特征，以辨别某些流体和/或流体混合物的存在。 通过观察电路的谐振电子特性的变化来测量所用材料的介电性质，尺寸，电阻，电荷转移和其它变化的变化来检测流体的存在。 通过使用诸如主成分分析（PCA）等的数学方法，可以在彼此存在的情况下检测多种流体和混合物，即使在高湿度环境或其中一种或多种流体具有显着更高浓度的环境 （例如10×1,000,000×）与混合物中的其他成分相比。

    CELL CARRIERS AND METHODS FOR CULTURING CELLS
    8.
    发明申请
    CELL CARRIERS AND METHODS FOR CULTURING CELLS 有权
    细胞载体和培养细胞的方法

    公开(公告)号：US20130210140A1

    公开(公告)日：2013-08-15

    申请号：US13839409

    申请日：2013-03-15

    Applicant: GENERAL ELECTRIC COMPANY

    Inventor： Andrew Arthur Paul Burns ,  David Gilles Gascoyne ,  Scott Michael Miller

    IPC: C12M1/32

    CPC classification number: C12M23/12 ,  C12N5/0068 ,  C12N2533/30 ,  C12N2535/10

    Abstract: A carrier for growing stem cells is provided, the carrier comprises a substrate comprising one or more outer surfaces; and a hydrophilic, water soluble coating material disposed and dried on one or more of the outer surfaces. The carrier comprises one or more structured indentations on one or more of the outer surfaces, wherein the carrier has a length at least about 0.2 mm, a width at least about 0.2 mm, and a height in a range from about 0.05 mm to 1.2 mm and each of the structured indentations has a major axis in a range from about 0.1 mm to 0.5 mm, a minor axis in a range from about 0.1 mm to 0.5 mm and a depth in a range from about 0.025 mm to about 0.5 mm. A method of culturing stem cells and stromal cells using the same carrier are also provided.

    Abstract translation: 提供了用于生长干细胞的载体，载体包括包含一个或多个外表面的基底; 以及在一个或多个外表面上设置和干燥的亲水的水溶性涂层材料。 载体在一个或多个外表面上包括一个或多个结构化的凹陷，其中载体的长度至少约0.2mm，宽度至少约0.2mm，高度在约0.05mm至1.2mm 并且每个所述结构化缺口具有在约0.1mm至0.5mm的范围内的长轴，在约0.1mm至0.5mm的范围内的短轴和在约0.025mm至约0.5mm的范围内的深度。 还提供了使用相同载体培养干细胞和基质细胞的方法。

    MICRONEEDLE-INTEGRATED INTERSTITIAL FLUID BIOMARKER SENSOR SYSTEMS AND METHODS THEREOF
    9.
    发明申请
    MICRONEEDLE-INTEGRATED INTERSTITIAL FLUID BIOMARKER SENSOR SYSTEMS AND METHODS THEREOF 有权

    公开(公告)号：US20250064349A1

    公开(公告)日：2025-02-27

    申请号：US18456193

    申请日：2023-08-25

    Applicant: General Electric Company

    Inventor： Andrew Arthur Paul Burns ,  Azar Alizadeh ,  Ralf Lenigk

    IPC: A61B5/145 ,  A61B5/00

    Abstract: A wearable interstitial fluid (ISF) sensing includes a first patch layer and an electronics module component layer. The electronics module component layer is laminated to the first patch layer to form a patch component and a plurality of microneedles extending from the patch component. The electronics module component layer includes a substrate and a sensor positioned on the substrate. Each microneedle of the plurality of microneedles includes a microneedle base extending from the patch component, a body extending from the microneedle base, and a tip extending from the body. The body defines a slot extending through the first patch layer of the body. The slot defines a first opening and a second opening. The at least one sensor is positioned over the second opening. The first opening, the slot, and the sensor define a channel exposed to the environment. The channel is configured to channel ISF to the sensor.

    FUNCTIONALIZED PEPTIDE TRANSPORTERS FOR CELLULAR UPTAKE
    10.
    发明申请
    FUNCTIONALIZED PEPTIDE TRANSPORTERS FOR CELLULAR UPTAKE 审中-公开
    用于细胞摄取的功能性肽运输机

    公开(公告)号：US20170035914A1

    公开(公告)日：2017-02-09

    申请号：US14818372

    申请日：2015-08-05

    Applicant: General Electric Company

    Inventor： Erik Leeming Kvam ,  Michael James Rishel ,  Andrew Arthur Paul Burns

    IPC: A61K49/00

    CPC classification number: A61K49/0056 ,  A61K49/0043

    Abstract: Disclosed are novel cell-penetrating transporters for enhancing cellular uptake of peptide fusion proteins into live cells. The cell-penetrating transporters comprise a functionalized peptide construct comprising a cell importation peptide covalently bound to a cargo, the cell importation peptide in an unreactive monomeric form, and a pharmaceutical carrier. In certain embodiments, the cargo further comprises a nuclear localization sequence (NLS) allowing the cargo to be transported across the nuclear membrane.

    Abstract translation: 公开了用于增强肽融合蛋白到活细胞中的细胞摄取的新型细胞穿透转运蛋白。 细胞穿透转运蛋白包含功能化的肽构建体，其包含与货物共价结合的细胞进入肽，细胞进口肽以非反应性单体形式和药物载体。 在某些实施方案中，货物还包括允许货物跨过核膜运输的核定位序列（NLS）。

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