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    Soft magnetic phase nanoparticles preparations and associated methods thereof
    7.
    发明授权
    Soft magnetic phase nanoparticles preparations and associated methods thereof 有权
    软磁性相纳米颗粒制剂及其相关方法

    公开(公告)号：US09251938B2

    公开(公告)日：2016-02-02

    申请号：US13788218

    申请日：2013-03-07

    Applicant: General Electric Company

    Inventor： Binil Itty Ipe Kandapallil ,  Robert Edgar Colborn ,  Peter John Bonitatibus, Jr. ,  Francis Johnson

    IPC: H01F1/01 ,  B22F1/00 ,  B22F9/24 ,  H01F1/00

    CPC classification number: H01F1/0054 ,  B22F1/0018 ,  B22F9/24

    Abstract: A method of synthesizing magnetic nanoparticles comprising soft magnetic phases is provided, wherein the method comprises degassing a first mixture at a temperature in a range from about 80° C. to 130° C. The first mixture comprises a solvent, a compound comprising iron, cobalt, or combinations thereof dissolved in the solvent, and an organic component comprising a fatty acid or an amine. Degassing the first mixture is followed by adding a capping ligand to the first mixture under inert atmosphere to form a second mixture; adding a reducing agent to the second mixture at a temperature in a processing temperature range from about 250° C. to about 350° C. to form a third mixture; and incubating the third mixture at a temperature within the processing temperature range to form nanoparticles comprising a soft magnetic phase.

    Abstract translation: 提供了一种合成包含软磁相的磁性纳米颗粒的方法，其中该方法包括在约80℃至130℃的温度范围内对第一混合物进行脱气。第一混合物包含溶剂，包含铁， 钴或其组合，以及包含脂肪酸或胺的有机组分。 在第一混合物中脱气之后，在惰性气氛下向第一混合物中加入封端配体以形成第二混合物; 在约250℃至约350℃的加工温度范围内的温度下向第二混合物中加入还原剂以形成第三混合物; 并在处理温度范围内的温度下培养第三混合物以形成包含软磁相的纳米颗粒。

    TREATING WATER INSOLUBLE NANOPARTICLES WITH HYDROPHILIC ALPHA-HYDROXYPHOSPHONIC ACID CONJUGATES, THE SO MODIFIED NANOPARTICLES AND THEIR USE AS CONTRAST AGENTS
    10.
    发明申请
    TREATING WATER INSOLUBLE NANOPARTICLES WITH HYDROPHILIC ALPHA-HYDROXYPHOSPHONIC ACID CONJUGATES, THE SO MODIFIED NANOPARTICLES AND THEIR USE AS CONTRAST AGENTS 有权
    用水解ALPHA-羟基磷酸共聚物处理水不溶性纳米颗粒，该改性纳米粒子及其作为对比剂的用途

    公开(公告)号：US20160038617A1

    公开(公告)日：2016-02-11

    申请号：US14919077

    申请日：2015-10-21

    Applicant: General Electric Company

    Inventor： Brian Christopher Bales ,  Bruce Allan Hay ,  Binil Itty Ipe Kandapallil

    IPC: A61K49/18

    CPC classification number: A61K49/1857 ,  A61K49/0428 ,  A61K49/1842 ,  A61K49/186 ,  B82Y5/00

    Abstract: The present application discloses treating water insoluble nanoparticles, particularly nanoparticles of metals and metal compounds which find utility in diagnostic imaging such as MR and X-ray imaging, with an alpha-hydroxyphosphonic acid conjugate with a hydrophilic moiety to render the nanoparticles sufficiently hydrophilic to find utility in diagnostic imaging. Among the modified hydrophilic nanoparticles disclosed are those in which the hydrophilic moieties of the modifying conjugate are ethylene oxide based polymers and copolymers and zwitterions and the nanoparticles are composed of transition metal oxides such as superparamagnetic iron oxide and tantalum oxide. Disclosed are nanoparticles which are sufficiently hydrophilic to form stable aqueous colloidal suspensions. Also disclosed is diagnostic imaging such as MR and X-ray using the modified hydrophilic nanoparticles as contrast agents.

    Abstract translation: 本申请公开了处理水不溶性纳米颗粒，特别是金属和金属化合物的纳米颗粒，其在诊断成像如MR和X射线成像中具有与亲水部分的α-羟基膦酸缀合物的效用，以使纳米颗粒充分亲水以发现 在诊断成像中的应用。 所公开的改性亲水性纳米粒子中的那些是其中改性缀合物的亲水部分是环氧乙烷基聚合物和共聚物和两性离子，并且纳米颗粒由过渡金属氧化物如超顺磁性氧化铁和氧化钽组成。 公开了足够亲水以形成稳定的水性胶体悬浮液的纳米颗粒。 还公开了使用修饰的亲水性纳米颗粒作为造影剂的诊断成像如MR和X射线。

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