公开(公告)号：US20180305717A1

公开(公告)日：2018-10-25

申请号：US16029870

申请日：2018-07-09

Applicant: GENETHON

Inventor： LIONEL GALIBERT ,  OTTO-WILHELM MERTEN ,  AURELIEN JACOB

IPC: C12N15/86 ,  C12N7/00

CPC classification number: C12N15/86 ,  C12N7/00 ,  C12N2710/14044 ,  C12N2750/14043 ,  C12N2750/14141 ,  C12N2750/14151 ,  C12N2800/50 ,  C12N2830/20 ,  C12N2999/007

Abstract: The invention relates to a recombinant baculoviral genome useful for the production of viral vectors for gene therapy, allowing said production from a single infection

公开(公告)号：US20170002332A1

公开(公告)日：2017-01-05

申请号：US15105880

申请日：2014-12-17

Applicant: GENETHON

Inventor： DRISS BOUDEFFA ,  OTTO-WILHELM MERTEN ,  DAVID FENARD

IPC: C12N7/00 ,  C12N15/86

CPC classification number: C12N7/00 ,  C12N15/86 ,  C12N2740/15043 ,  C12N2740/15051 ,  C12N2740/16043 ,  C12N2740/16051

Abstract: The invention relates to a process for purifying enveloped viruses. The process of the invention is useful for recovering at a large scale enveloped viruses under conditions complying with good manufacturing practices and allowing viruses of a clinical grade to be obtained.

Abstract translation: 本发明涉及一种净化包膜病毒的方法。 本发明的方法可用于在符合良好制造实践和允许获得临床级病毒的条件下在大规模包膜病毒下恢复。

公开(公告)号：US20150252335A1

公开(公告)日：2015-09-10

申请号：US14670459

申请日：2015-03-27

Applicant: Genethon

Inventor： OTTO-WILHELM MERTEN ,  MARTIN MAREK ,  MONIQUE VAN OERS

IPC: C12N7/00 ,  C12N15/86

CPC classification number: C12N7/00 ,  C12N15/86 ,  C12N2710/14143 ,  C12N2710/14152 ,  C12N2750/14143 ,  C12N2800/50

Abstract: The present invention relates to methods for the production of biopharmaceuticals implementing a baculovirus-based system. These methods advantageously allow the production of biopharmaceuticals with a reduced number of or without contaminating baculoviral virions.

Abstract translation: 本发明涉及生产实施基于杆状病毒的系统的生物药物的方法。 这些方法有利地允许生产具有减少数量的或不含有污染性杆状病毒病毒粒子的生物药物。

公开(公告)号：US20200002683A1

公开(公告)日：2020-01-02

申请号：US16551787

申请日：2019-08-27

Applicant: GENETHON

Inventor： OTTO-WILHELM MERTEN ,  MARTIN MAREK ,  MONIQUE VAN OERS

IPC: C12N7/00 ,  C12N15/86

Abstract: The present invention relates to methods for the production of biopharmaceuticals implementing a baculovirus-based system. These methods advantageously allow the production of biopharmaceuticals with a reduced number of or without contaminating baculoviral virions.

公开(公告)号：US20200069790A1

公开(公告)日：2020-03-05

申请号：US16490181

申请日：2018-03-01

Applicant: GENETHON ,  INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) ,  SORBONNE UNIVERSITÉ ,  ASSOCIATION INSTITUT DE MYOLOGIE

Inventor： BÉRANGÉRE BERTIN ,  CAROLE MASURIER ,  OTTO-WILHELM MERTEN ,  FEDERICO MINGOZZI

IPC: A61K39/235 ,  A61M1/36 ,  C07K16/08 ,  C07K16/06 ,  C12N7/00

Abstract: The present invention relates to a method for removing undesired anti-AAV antibodies from a blood-derived composition.

公开(公告)号：US20180127728A1

公开(公告)日：2018-05-10

申请号：US15841359

申请日：2017-12-14

Applicant: GENETHON

Inventor： OTTO-WILHELM MERTEN ,  MARTIN MAREK ,  MONIQUE VAN OERS

IPC: C12N7/00 ,  C12N15/86

CPC classification number: C12N7/00 ,  C12N15/86 ,  C12N2710/14143 ,  C12N2710/14152 ,  C12N2750/14143 ,  C12N2800/50

Abstract: The present invention relates to methods for the production of biopharmaceuticals implementing a baculovirus-based system. These methods advantageously allow the production of biopharmaceuticals with a reduced number of or without contaminating baculoviral virions.