公开(公告)号：US20140206545A1

公开(公告)日：2014-07-24

申请号：US14132679

申请日：2013-12-18

申请人： NSABP FOUNDATION, INC. ,  GENOMIC HEALTH, INC.

发明人： Joffre B. BAKER ,  Wayne COWENS ,  Kim M. CLARK-LANGONE ,  James HACKETT ,  Drew WATSON ,  Soonmyung PAIK

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/57419 ,  G01N2800/52

摘要： The present invention relates to gene sets useful in assessing prognosis and/or predicting the response of cancer, e.g. colorectal cancer to chemotherapy. In addition, the invention relates to a clinically validated cancer test, e.g. colorectal test, for assessment of prognosis and/or prediction of patient response to chemotherapy, using expression analysis. The present invention accommodates the use of archived paraffin embedded biopsy material for assay of all markers in the relevant gene sets and therefore is compatible with the most widely available type of biopsy material.

摘要翻译： 本发明涉及可用于评估预后和/或预测癌症反应的基因集，例如 结肠直肠癌化疗。 此外，本发明涉及临床验证的癌症测试，例如， 使用表达分析来评估预后和/或预测患者对化学疗法的反应。 本发明适用于存档石蜡包埋的活检材料用于相关基因组中所有标记物的测定，因此与最广泛可用的活检材料类型相容。

公开(公告)号：US20170121780A1

公开(公告)日：2017-05-04

申请号：US15368979

申请日：2016-12-05

申请人： GENOMIC HEALTH, INC.

发明人： Wayne COWENS ,  Steven SHAK ,  Audrey GODDARD ,  Dejan KNEZEVIC ,  Joffre BAKER ,  Michael C. KIEFER ,  Tara MADDALA ,  Frederick L. BAEHNER

IPC分类号： C12Q1/68 ,  G06N7/00 ,  G06F19/00 ,  G06F19/10

CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/57438 ,  G06N7/005 ,  G16B99/00 ,  G16H50/20

摘要： The present disclosure provides gene and gene sets, the expression of which is important in the classification and/or prognosis of cancer, in particular of renal cell carcinoma.

公开(公告)号：US20210166790A1

公开(公告)日：2021-06-03

申请号：US16952566

申请日：2020-11-19

申请人： Genomic Health, Inc.

发明人： Wayne COWENS ,  Steven SHAK ,  Audrey GODDARD ,  Dejan KNEZEVIC ,  Joffre BAKER ,  Michael C. KIEFER ,  Tara MADDALA ,  Frederick L. BAEHNER

IPC分类号： G16B99/00 ,  G06N7/00 ,  G01N33/574

摘要： The present disclosure provides gene and gene sets, the expression of which is important in the classification and/or prognosis of cancer, in particular of renal cell carcinoma.

公开(公告)号：US20200255911A1

公开(公告)日：2020-08-13

申请号：US16800292

申请日：2020-02-25

申请人： GENOMIC HEALTH, INC.

发明人： Steven SHAK ,  Frederick L. BAEHNER ,  Tara MADDALA ,  Mark LEE ,  Robert J. PELHAM ,  Wayne COWENS ,  Diana CHERBAVAZ ,  Michael C. KIEFER ,  Michael CRAGER ,  Audrey GODDARD ,  Joffre B. BAKER

IPC分类号： C12Q1/6886

摘要： Molecular assays that involve measurement of expression levels of prognostic biomarkers, or co-expressed biomarkers, from a biological sample obtained from a prostate cancer patient, and analysis of the measured expression levels to provide information concerning the likely prognosis for said patient, and likelihood that said patient will have a recurrence of prostate cancer, or to classify the tumor by likelihood of clinical outcome or TMPRSS2 fusion status, are provided herein.

公开(公告)号：US20190249260A1

公开(公告)日：2019-08-15

申请号：US16282540

申请日：2019-02-22

申请人： GENOMIC HEALTH, INC.

发明人： Steven SHAK ,  Frederick L. BAEHNER ,  Tara MADDALA ,  Mark LEE ,  Robert J. PELHAM ,  Wayne COWENS ,  Diana CHERBAVAZ ,  Michael C. KIEFER ,  Michael CRAGER ,  Audrey GODDARD ,  Joffre B. BAKER

IPC分类号： C12Q1/6886

CPC分类号： C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/178

摘要： Molecular assays that involve measurement of expression levels of prognostic biomarkers, or co-expressed biomarkers, from a biological sample obtained from a prostate cancer patient, and analysis of the measured expression levels to provide information concerning the likely prognosis for said patient, and likelihood that said patient will have a recurrence of prostate cancer, or to classify the tumor by likelihood of clinical outcome or TMPRSS2 fusion status, are provided herein.

公开(公告)号：US20160097105A1

公开(公告)日：2016-04-07

申请号：US14887605

申请日：2015-10-20

申请人： GENOMIC HEALTH, INC.

发明人： Steven SHAK ,  Frederick L. BAEHNER ,  Tara MADDALA ,  Mark LEE ,  Robert J. PELHAM ,  Wayne COWENS ,  Diana CHERBAVAZ ,  Michael C. KIEFER ,  Michael CRAGER ,  Audrey GODDARD ,  Joffre B. BAKER

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/178 ,  G06F19/00

摘要： Molecular assays that involve measurement of expression levels of prognostic biomarkers, or co-expressed biomarkers, from a biological sample obtained from a prostate cancer patient, and analysis of the measured expression levels to provide information concerning the likely prognosis for said patient, and likelihood that said patient will have a recurrence of prostate cancer, or to classify the tumor by likelihood of clinical outcome or TMPRSS2 fusion status, are provided herein.

摘要翻译： 涉及从前列腺癌患者获得的生物样品中测量预后生物标志物或共表达生物标志物的表达水平的分子测定，以及测量的表达水平的分析以提供关于所述患者的可能预后的信息，以及可能性 所述患者将具有前列腺癌的复发，或通过临床结果或TMPRSS2融合状态的可能性来分类肿瘤。