-
公开(公告)号：US20240218051A1
公开(公告)日：2024-07-04
申请号：US18534085
申请日：2023-12-08
Applicant: GENZYME CORPORATION
Inventor： Qun Zhou , Sunghae Park , Huawei Qiu , Marie-Priscille Brun , Francis Duffieux
CPC classification number: C07K16/00 , A61K47/6803 , C07K2317/14 , C07K2317/52 , C07K2317/56 , C07K2317/94
Abstract: Engineered antibodies that are stable and can be conjugated to a ligand or drug at a ligand/drug to antibody ratio of above 3, making these conjugates suitable for treatment of a variety of indications, are provided. Methods of producing these engineered antibodies are also provided.
-
公开(公告)号：US20230391849A1
公开(公告)日：2023-12-07
申请号：US18303353
申请日：2023-04-19
Applicant: GENZYME CORPORATION
Inventor： Qun Zhou , Sunghae Park , Huawei Qiu , Marie-Priscille Brun , Francis Duffieux
CPC classification number: C07K16/00 , A61K47/6803 , C07K2317/14 , C07K2317/52 , C07K2317/56 , C07K2317/94
Abstract: Engineered antibodies that are stable and can be conjugated to a ligand or drug at a ligand/drug to antibody ratio of above 3, making these conjugates suitable for treatment of a variety of indications, are provided. Methods of producing these engineered antibodies are also provided.
-
公开(公告)号：US20210163584A1
公开(公告)日：2021-06-03
申请号：US17079285
申请日：2020-10-23
Applicant: Genzyme Corporation
Inventor： Huawei Qiu , Sunghae Park , James Stefano
Abstract: Provided are recombinant and chemically-conjugated antibodies and fragments thereof modified with one or more poly-aspartate (poly-D) peptides (e.g., a D10 sequence) to improve localization of the antibodies or fragments to bone. Methods of making and using of these antibodies and fragments also are disclosed.
-
公开(公告)号：US10730936B2
公开(公告)日：2020-08-04
申请号：US15670631
申请日：2017-08-07
Applicant: GENZYME CORPORATION
Inventor： Ronnie Wei , Aaron Moulin , Magali Mathieu , Clark Pan , Sunghae Park , Huawei Qiu
IPC: A61K39/00 , A61K39/395 , C07K16/22
Abstract: Antibodies or antigen-binding fragments thereof are engineered to bind Transforming Growth Factor-β (TGFβ). TGFβ-isoform selective antibodies or antigen-binding fragments thereof may selectively bind human TGFβ1, compared to human TGFβ2 and human TGFβ3, or may selectively bind human TGFβ3, compared to human TGFβ1 and human TGFβ2. The design of the antibodies or antigen-binding fragments thereof is facilitated by a co-crystal structure of a recombinant Fab fragment of GC1008 bound to TGFβ2 and by another co-crystal structure of the scFv version of GC1008 bound to TGFβ1.
-
公开(公告)号：US20180208650A1
公开(公告)日：2018-07-26
申请号：US15875125
申请日：2018-01-19
Applicant: Genzyme Corporation
Inventor： Huawei Qiu , Sunghae Park , James Stefano
CPC classification number: C07K16/22 , A61K47/68 , A61K2039/505 , A61P13/12 , A61P19/08 , A61P19/10 , A61P35/04 , C07K7/06 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/00
Abstract: Provided are recombinant and chemically-conjugated antibodies and fragments thereof modified with one or more poly-aspartate (poly-D) peptides (e.g., a D10 sequence) to improve localization of the antibodies or fragments to bone. Methods of making and using of these antibodies and fragments also are disclosed.
-
Patent Agency Ranking
公开(公告)号：US11505611B2
公开(公告)日：2022-11-22
申请号：US17407774
申请日：2021-08-20
Applicant: GENZYME CORPORATION
Inventor： Yves Sabbagh , Yangde Chen , William Brondyk , Huawei Qiu , Sunghae Park , Ronnie Wei , Yu Qiu , Yanfeng Zhou , Cendrine Lemoine , HyunSuk Cho
Abstract: Anti-FGFR3 antigen-binding proteins and antigen-binding binding fragments thereof are provided. Methods of inhibiting FGFR3 activity and methods of treating FGFR3-mediated diseases and disorders are also provided.
-
公开(公告)号：US20170342144A1
公开(公告)日：2017-11-30
申请号：US15670631
申请日：2017-08-07
Applicant: GENZYME CORPORATION
Inventor： Ronnie Wei , Aaron Moulin , Magali Mathieu , Clark Pan , Sunghae Park , Huawei Qiu
Abstract: Antibodies or antigen-binding fragments thereof are engineered to bind Transforming Growth Factor-β (TGFβ). TGFβ-isoform selective antibodies or antigen-binding fragments thereof may selectively bind human TGFβ1, compared to human TGFβ2 and human TGFβ3, or may selectively bind human TGFβ3, compared to human TGFβ1 and human TGFβ2. The design of the antibodies or antigen-binding fragments thereof is facilitated by a co-crystal structure of a recombinant Fab fragment of GC1008 bound to TGFβ2 and by another co-crystal structure of the scFv version of GC1008 bound to TGFβ1.
-
公开(公告)号：US09783604B2
公开(公告)日：2017-10-10
申请号：US14773950
申请日：2014-03-11
Applicant: GENZYME CORPORATION
Inventor： Ronnie Wei , Aaron Moulin , Magali Mathieu , Clark Pan , Sunghae Park , Huawei Qiu
IPC: C07K16/22 , A61K39/395 , C12N15/13 , A61K39/00
CPC classification number: C07K16/22 , A61K2039/505 , C07K2317/21 , C07K2317/55 , C07K2317/567 , C07K2317/622 , C07K2317/76 , C07K2317/92
Abstract: Antibodies or antigen-binding fragments thereof are engineered to bind Transforming Growth Factor-β (TGFβ). TGFβ-isoform selective antibodies or antigen-binding fragments thereof may selectively bind human TGFβ1, compared to human TGFβ2 and human TGFβ3, or may selectively bind human TGFβ3, compared to human TGFβ1 and human TGFβ2. The design of the antibodies or antigen-binding fragments thereof is facilitated by a co-crystal structure of a recombinant Fab fragment of GC1008 bound to TGFβ2 and by another co-crystal structure of the scFv version of GC1008 bound to TGFβ1.
-
公开(公告)号：US12098194B2
公开(公告)日：2024-09-24
申请号：US17079285
申请日：2020-10-23
Applicant: Genzyme Corporation
Inventor： Huawei Qiu , Sunghae Park , James Stefano
IPC: A61K39/395 , A61K47/68 , A61P13/12 , A61P19/08 , A61P19/10 , A61P35/04 , C07K7/06 , C07K16/22 , A61K39/00
CPC classification number: C07K16/22 , A61K39/3955 , A61K47/68 , A61P13/12 , A61P19/08 , A61P19/10 , A61P35/04 , C07K7/06 , A61K2039/505 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/00
Abstract: Provided are recombinant and chemically-conjugated antibodies and fragments thereof modified with one or more poly-aspartate (poly-D) peptides (e.g., a D10 sequence) to improve localization of the antibodies or fragments to bone. Methods of making and using of these antibodies and fragments also are disclosed.
-
公开(公告)号：US11879004B2
公开(公告)日：2024-01-23
申请号：US17187039
申请日：2021-02-26
Applicant: GENZYME CORPORATION
Inventor： Qun Zhou , Sunghae Park , Huawei Qiu , Marie-Priscille Brun , Francis Duffieux
CPC classification number: C07K16/00 , A61K47/6803 , C07K2317/14 , C07K2317/52 , C07K2317/56 , C07K2317/94
Abstract: Engineered antibodies that are stable and can be conjugated to a ligand or drug at a ligand/drug to antibody ratio of above 3, making these conjugates suitable for treatment of a variety of indications, are provided. Methods of producing these engineered antibodies are also provided.
-
-
-
-
-
-
-
-
-
Search Results
11
records
(took 0.017 seconds)
