-
公开(公告)号：US20150374841A1
公开(公告)日：2015-12-31
申请号：US14728572
申请日：2015-06-02
申请人： Geron Corporation
IPC分类号： A61K47/48
CPC分类号： A61K47/48092 , A61K47/549 , C07H21/00
摘要： Oligonucleotide conjugates, where an oligonucleotide is covalently attached to an aromatic system, are provided. In particular embodiments the oligonucleotide is complementary to the RNA component of human telomerase and is covalently attached to a nucleobase via an optional linker. The conjugates inhibit telomerase enzyme activity.
摘要翻译： 提供寡核苷酸共轭物，其中寡核苷酸共价连接到芳族体系上。 在具体实施方案中，寡核苷酸与人端粒酶的RNA组分互补，并通过任选的接头共价连接于核碱基。 缀合物抑制端粒酶的活性。
-
公开(公告)号：US09072790B2
公开(公告)日：2015-07-07
申请号：US13892065
申请日：2013-05-10
申请人： Geron Corporation
CPC分类号： A61K47/48092 , A61K47/549 , C07H21/00
摘要： Oligonucleotide conjugates, where an oligonucleotide is covalently attached to an aromatic system, are provided. In particular embodiments the oligonucleotide is complementary to the RNA component of human telomerase and is covalently attached to a nucleobase via an optional linker. The conjugates inhibit telomerase enzyme activity.
-
公开(公告)号：US20150087064A1
公开(公告)日：2015-03-26
申请号：US14317418
申请日：2014-06-27
发明人： Gregg B. Morin
IPC分类号： C12N15/113 , C12N9/12
CPC分类号： C12N15/1137 , A61K38/00 , C12N9/1241 , C12N9/1276 , C12N2310/11
摘要： The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. Catalytically inactive variants comprising deletions or other mutations are provided.
摘要翻译： 本发明提供了与人类端粒酶逆转录酶（hTRT），人端粒酶的催化蛋白质亚基相关的组合物和方法。 提供了包含缺失或其他突变的催化非活性变体。
-
公开(公告)号：US09572891B2
公开(公告)日：2017-02-21
申请号：US14728572
申请日：2015-06-02
申请人： Geron Corporation
IPC分类号： C07H21/00 , A61K31/7088 , A61K47/48
CPC分类号： A61K47/48092 , A61K47/549 , C07H21/00
摘要： Oligonucleotide conjugates, where an oligonucleotide is covalently attached to an aromatic system, are provided. In particular embodiments the oligonucleotide is complementary to the RNA component of human telomerase and is covalently attached to a nucleobase via an optional linker. The conjugates inhibit telomerase enzyme activity.
摘要翻译： 提供寡核苷酸共轭物，其中寡核苷酸共价连接到芳族体系上。 在具体实施方案中，寡核苷酸与人端粒酶的RNA组分互补，并通过任选的接头共价连接于核碱基。 缀合物抑制端粒酶的活性。
-
5.发明申请Method for Eliciting an Immune Response to Human Telomerase Reverse Transcriptase 审中-公开引起人端粒酶逆转录酶免疫反应的方法公开(公告)号：US20150250863A1
公开(公告)日：2015-09-10
申请号：US14190021
申请日：2014-02-25
发明人： Thomas R. Cech , Joachim Lingner , Toru M. Nakamura , Karen B. Chapman , Gregg B. Morin , Calvin B. Harley , William H. Andrews
CPC分类号： A61K39/0011 , A01K2217/05 , A61K38/00 , A61K39/0005 , A61K39/39 , A61K48/00 , A61K2039/55505 , A61K2039/55511 , A61K2039/55516 , A61K2039/55544 , A61K2039/55566 , A61K2039/575 , C07K14/43504 , C07K16/40 , C07K2319/00 , C12N9/1241 , C12N9/1276 , C12N15/113 , C12N15/1137 , C12N2310/15 , C12N2310/315 , C12Q1/6895 , C12Q2600/156 , C12Q2600/158 , C12Y207/07049
摘要： The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis and treatment of human diseases, for changing the proliferative capacity of cells and organisms, and for identification and screening of compounds and treatments useful for treatment of diseases such as cancers.
摘要翻译： 本发明提供了与人类端粒酶逆转录酶（hTRT），人端粒酶的催化蛋白质亚基相关的组合物和方法。 本发明的多核苷酸和多肽可用于人类疾病的诊断，预后和治疗，用于改变细胞和生物体的增殖能力，以及用于鉴定和筛选用于治疗诸如癌症的疾病的化合物和治疗。
-
公开(公告)号：US20130253042A1
公开(公告)日：2013-09-26
申请号：US13892065
申请日：2013-05-10
申请人： GERON CORPORATION
IPC分类号： A61K47/48
CPC分类号： A61K47/48092 , A61K47/549 , C07H21/00
摘要： Oligonucleotide conjugates, where an oligonucleotide is covalently attached to an aromatic system, are provided. In particular embodiments the oligonucleotide is complementary to the RNA component of human telomerase and is covalently attached to a nucleobase via an optional linker. The conjugates inhibit telomerase enzyme activity.
-
-
-
-
-
搜索结果
6 条记录 (耗时 0.026 秒)
