公开(公告)号：US20200222526A1

公开(公告)日：2020-07-16

申请号：US16630951

申请日：2018-07-16

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Kathryn HASHEY ,  Padma MALYALA ,  Marcelo SAMSA ,  Olga SLACK ,  Dong YU ,  Alan STOKES ,  Rashmi JALAH

IPC: A61K39/205 ,  A61K9/127

Abstract: Nucleic acid based vaccine constructs encoding Lyssaviral antigens are useful in preventing and treating diseases. Self-amplifying RNA molecules encoding Lyssaviral antigens provide potent and long-lasting immunity.

公开(公告)号：US20240189417A1

公开(公告)日：2024-06-13

申请号：US18425426

申请日：2024-01-29

Applicant: GlaxoSmithKline Biologicals SA

Inventor： Giulietta MARUGGI ,  Qiongman KONG ,  Varnika ROY ,  Dong YU ,  Meng ZHANG

IPC: A61K39/215 ,  A61K39/00 ,  A61K39/02 ,  A61P31/14 ,  A61P37/04 ,  C12P19/34

CPC classification number: A61K39/215 ,  A61K39/0002 ,  A61K39/0011 ,  A61K39/0013 ,  A61K39/02 ,  A61P31/14 ,  A61P37/04 ,  C12P19/34 ,  A61K2039/53

Abstract: Provided herein are RNA that: are collectively self-amplifying in an intracellular environment, comprise N1-methyl-pseudouridines and uridines, and have a mole percentage or mole proportion of the N1-methylpseudouridines to the total of the uridines and the Ni-methylpseudouridines or a mole ration of the N1-methylpseudouridines to the uridines.

公开(公告)号：US20240301006A1

公开(公告)日：2024-09-12

申请号：US18269120

申请日：2021-12-21

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Giulietta MARUGGI ,  Jason William WESTERBECK ,  Dong YU

IPC: C07K14/005 ,  A61K9/127 ,  A61K39/00 ,  C12N15/86

CPC classification number: C07K14/005 ,  A61K9/127 ,  C12N15/86 ,  A61K39/00 ,  A61K2039/55555 ,  A61K2039/572 ,  A61K2039/575 ,  C12N2710/24122 ,  C12N2710/24133 ,  C12N2760/14122 ,  C12N2760/14133 ,  C12N2760/16122 ,  C12N2760/16133 ,  C12N2770/36143

Abstract: Compounds useful as components of immunogenic compositions for the induction of an immunogenic response in a subject against infection, methods for their use in treatment, and processes for their manufacture are provided herein. The compounds comprise a nucleic acid construct comprising a sequence which encodes an interferon effector.

公开(公告)号：US20230364219A1

公开(公告)日：2023-11-16

申请号：US17918676

申请日：2021-04-16

Applicant: GlaxoSmithKline Biologicals SA

Inventor： Dong YU ,  Giulietta MARUGGI ,  Jason W. WESTERBECK ,  Jeffrey B. ULMER ,  Jason P. LALIBERTE ,  Kate LUISI ,  Lin QU

IPC: A61K39/215 ,  A61P37/04

CPC classification number: A61K39/215 ,  A61P37/04 ,  A61K2039/55566

Abstract: Compounds useful as components of immunogenic compositions for the induction of an immunogenic response in a subject against infection, methods for their use in treatment, and processes for their manufacture are provided herein. The compounds comprise a nucleic acid construct comprising a sequence which encodes an antigen, in particular a Coronavirus antigen.