公开(公告)号：US11827694B2

公开(公告)日：2023-11-28

申请号：US18173006

申请日：2023-02-22

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Kurt Swanson ,  Philip R. Dormitzer

IPC: C07K16/10 ,  A61K39/155 ,  A61K39/12 ,  C07K14/005 ,  A61K39/00

CPC classification number: C07K16/1027 ,  A61K39/12 ,  A61K39/155 ,  C07K14/005 ,  A61K39/00 ,  A61K2039/5252 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/53 ,  A61K2039/55505 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/55566 ,  A61K2039/55572 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/50 ,  C07K2319/73 ,  C12N2760/18522 ,  C12N2760/18534 ,  C12N2770/36143

Abstract: The present invention relates to immunogenic compositions comprising RSV F protein, methods for preparing compositions that contain RSV F protein ecto-domain polypeptides, and to certain engineered RSV F proteins and nucleic acids that encode the engineered RSV F proteins. Compositions prepared using the methods can contain RSV F protein ecto-domain polypeptides in a predominant or single desired form and conformation. The invention also relates to methods for inducing an immune response to RSV F.

公开(公告)号：US12139512B2

公开(公告)日：2024-11-12

申请号：US17848230

申请日：2022-06-23

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Kurt Swanson ,  Andrea Carfi

IPC: C07K14/005 ,  A61K39/12 ,  A61K39/155 ,  A61K39/00

Abstract: The invention relates to pre-fusion RSV F protein and polypeptides that contain one or more amino acid mutations that stabilize the pre-fusion conformation or destabilize the post-fusion conformation. The invention also relates to methods for inducing an immune response to pre-fusion RSV F.

公开(公告)号：US11820812B2

公开(公告)日：2023-11-21

申请号：US17564962

申请日：2021-12-29

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Kurt Swanson ,  Philip R. Dormitzer

IPC: C07K16/10 ,  A61K39/155 ,  A61K39/12 ,  C07K14/005 ,  A61K39/00

CPC classification number: C07K16/1027 ,  A61K39/12 ,  A61K39/155 ,  C07K14/005 ,  A61K39/00 ,  A61K2039/5252 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/53 ,  A61K2039/55505 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/55566 ,  A61K2039/55572 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/50 ,  C07K2319/73 ,  C12N2760/18522 ,  C12N2760/18534 ,  C12N2770/36143

Abstract: The present invention relates to immunogenic compositions comprising RSV F protein, methods for preparing compositions that contain RSV F protein ecto-domain polypeptides, and to certain engineered RSV F proteins and nucleic acids that encode the engineered RSV F proteins. Compositions prepared using the methods can contain RSV F protein ecto-domain polypeptides in a predominant or single desired form and conformation. The invention also relates to methods for inducing an immune response to RSV F.

公开(公告)号：US20200172600A1

公开(公告)日：2020-06-04

申请号：US15678798

申请日：2017-08-16

Applicant: GLAXOSMITHKLINE BIOLOGICALS, SA

Inventor： Kurt Swanson ,  Philip R. Dormitzer

IPC: C07K16/10 ,  C07K14/005 ,  A61K39/12 ,  A61K39/155

Abstract: The present invention relates to immunogenic compositions comprising RSV F protein, methods for preparing compositions that contain RSV F protein ecto-domain polypeptides, and to certain engineered RSV F proteins and nucleic acids that encode the engineered RSV F proteins. Compositions prepared using the methods can contain RSV F protein ecto-domain polypeptides in a predominant or single desired form and conformation. The invention also relates to methods for inducing an immune response to RSV F.

公开(公告)号：US11261239B2

公开(公告)日：2022-03-01

申请号：US15678798

申请日：2017-08-16

Applicant: GLAXOSMITHKLINE BIOLOGICALS, SA

Inventor： Kurt Swanson ,  Philip R. Dormitzer

IPC: C07K16/10 ,  A61K39/155 ,  A61K39/12 ,  C07K14/005 ,  A61K39/00

Abstract: The present invention relates to immunogenic compositions comprising RSV F protein, methods for preparing compositions that contain RSV F protein ecto-domain polypeptides, and to certain engineered RSV F proteins and nucleic acids that encode the engineered RSV F proteins. Compositions prepared using the methods can contain RSV F protein ecto-domain polypeptides in a predominant or single desired form and conformation. The invention also relates to methods for inducing an immune response to RSV F.

公开(公告)号：US11655284B2

公开(公告)日：2023-05-23

申请号：US17848205

申请日：2022-06-23

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Kurt Swanson ,  Philip R. Dormitzer

IPC: C07K16/10 ,  A61K39/155 ,  A61K39/12 ,  C07K14/005 ,  A61K39/00

CPC classification number: C07K16/1027 ,  A61K39/12 ,  A61K39/155 ,  C07K14/005 ,  A61K39/00 ,  A61K2039/5252 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/53 ,  A61K2039/55505 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/55566 ,  A61K2039/55572 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/50 ,  C07K2319/73 ,  C12N2760/18522 ,  C12N2760/18534 ,  C12N2770/36143

Abstract: The present invention relates to immunogenic compositions comprising RSV F protein, methods for preparing compositions that contain RSV F protein ecto-domain polypeptides, and to certain engineered RSV F proteins and nucleic acids that encode the engineered RSV F proteins. Compositions prepared using the methods can contain RSV F protein ecto-domain polypeptides in a predominant or single desired form and conformation. The invention also relates to methods for inducing an immune response to RSV F.

公开(公告)号：US11629181B2

公开(公告)日：2023-04-18

申请号：US17848176

申请日：2022-06-23

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Kurt Swanson ,  Philip R. Dormitzer

IPC: C07K16/10 ,  A61K39/155 ,  A61K39/12 ,  C07K14/005 ,  A61K39/00

Abstract: The present invention relates to immunogenic compositions comprising RSV F protein, methods for preparing compositions that contain RSV F protein ecto-domain polypeptides, and to certain engineered RSV F proteins and nucleic acids that encode the engineered RSV F proteins. Compositions prepared using the methods can contain RSV F protein ecto-domain polypeptides in a predominant or single desired form and conformation. The invention also relates to methods for inducing an immune response to RSV F.