公开(公告)号：US20160378909A1

公开(公告)日：2016-12-29

申请号：US15104393

申请日：2014-12-15

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Philippe Marc Helene DEHOTTAY ,  Philippe GOFFIN ,  Bas TEUSINK ,  Filipe BRANCO DOS SANTOS

IPC: G06F19/12

CPC classification number: G16B5/00

Abstract: Methods for identifying culture conditions for a cell, the method comprising: (a) obtaining a genome scale stoichiometric metabolic model of the cell, and (b) performing constraint based optimization on the metabolic model of the cell using at least one yield based constraint.

Abstract translation: 用于鉴定细胞培养条件的方法，所述方法包括：（a）获得所述细胞的基因组规模化学计量代谢模型，和（b）使用至少一个基于产量的约束对所述细胞的代谢模型进行基于约束的优化。

公开(公告)号：US20170137475A1

公开(公告)日：2017-05-18

申请号：US15210245

申请日：2016-07-14

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Normand BLAIS ,  Philippe Marc Helene DEHOTTAY ,  Marianne DEWERCHIN ,  Philippe GOFFIN ,  Denis MARTIN

IPC: C07K14/34 ,  C12N9/10

CPC classification number: C07K14/34 ,  C07K1/00 ,  C07K2319/034 ,  C12N9/1077 ,  C12Y204/02036

Abstract: Compositions and methods related to periplasmic expression of a toxin including diphtheria toxin or CRM197 are provided herein.